Chemokines: A New Classification System and Their Role in Immunity
Albert Zlotnik,Osamu Yoshie +1 more
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This article is published in Immunity.The article was published on 2000-02-01 and is currently open access. It has received 3852 citations till now. The article focuses on the topics: CCL7.read more
Citations
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Journal ArticleDOI
The structure of human macrophage inflammatory protein-3alpha /CCL20. Linking antimicrobial and CC chemokine receptor-6-binding activities with human beta-defensins
David M. Hoover,Cyril Boulègue,De Yang,Joost J. Oppenheim,Kenneth D. Tucker,Wuyuan Lu,Jacek Lubkowski +6 more
TL;DR: In this paper, the x-ray crystal structure of human macrophage inflammatory protein-3alpha (MIP-3α) refined to a resolution of 1.7 A and compared with the crystal structures of human beta-defensin-1 and -2.
Journal ArticleDOI
Chemokines in rapid leukocyte adhesion triggering and migration
Brent Johnston,Eugene C. Butcher +1 more
TL;DR: The regulated expression of chemokines and their receptors is a critical determinant for homing of specialized lymphocyte subsets, and controls both tissue and inflammation-specific immune processes.
Journal ArticleDOI
The multifaceted roles of chemokines in malignancy.
TL;DR: The current review describes the multifaceted roles of chemokines in malignancy, addressing four major aspects of their activities: inducing leukocyte infiltration to tumors and regulating immune functions, with emphasis on tumor-associated macrophages.
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Overexpression of the CXCR5 chemokine receptor, and its ligand, CXCL13 in B cell chronic lymphocytic leukemia
Andrea Bürkle,Matthias Niedermeier,Annette Schmitt-Gräff,William G. Wierda,Michael J. Keating,Jan A. Burger +5 more
TL;DR: CXCR5 plays a role in CLL cell positioning and cognate interactions between CLL and CXCL13-secreting CD68+ accessory cells in lymphoid tissues, and levels correlated with beta2 microglobulin are reported.
Journal ArticleDOI
Chemokines, chemokine receptors, and allograft rejection.
Peter J. Nelson,Alan M. Krensky +1 more
TL;DR: Results with CCR1, CXCR3, and CX3CR1 blockades indicate that antagonists for chemokines and their receptors have the potential to become important therapeutics in treatment of acute and chronic allograft rejection.
References
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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
TL;DR: It is shown that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets, which are named central memory (TCM) and effector memory (TEM).
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Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
TL;DR: This is the first demonstration of the involvement of a G-protein-coupled chemokine receptor in neuronal cell migration and patterning in the central nervous system and may be important for designing strategies to block HIV entry into cells and for understanding mechanisms of pathogenesis in AIDS dementia.
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Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
Takashi Nagasawa,Seiichi Hirota,Kazunobu Tachibana,Nobuyuki Takakura,Shin-Ichi Nishikawa,Yukihiko Kitamura,Nobuaki Yoshida,Hitoshi Kikutani,Tadamitsu Kishimoto +8 more
TL;DR: It is shown that the chemokine PBSF/SDF-1 has several essential functions in development, including B-cell lymphopoiesis and bone-marrow myelopoiedis and a cardiac ventricular septal defect.
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CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.
Reinhold Förster,Andreas Schubel,Dagmar Breitfeld,Elisabeth Kremmer,Ingrid Renner-Müller,Eckhard Wolf,Martin Lipp +6 more
TL;DR: In this paper, the chemokine receptor CCR7 was identified as an important organizer of the primary immune response in mice, and severely delayed kinetics regarding the antibody response and lack contact sensitivity and delayed type hypersensitivity reactions.
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A new class of membrane-bound chemokine with a CX3C motif
J F Bazan,Kevin B. Bacon,Gary Hardiman,W Wang,K Soo,Devora L. Rossi,David R. Greaves,Albert Zlotnik,T J Schall +8 more
TL;DR: The structure, biochemical features, tissue distribution and chromosomal localization of CX3C chemokine all indicate that it represents a unique class of chemokines that may constitute part of the molecular control of leukocyte traffic at the endothelium.