Chemokines: A New Classification System and Their Role in Immunity
Albert Zlotnik,Osamu Yoshie +1 more
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This article is published in Immunity.The article was published on 2000-02-01 and is currently open access. It has received 3852 citations till now. The article focuses on the topics: CCL7.read more
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Human Induced Pluripotent Stem Cells for Tumor Targeted Delivery of Gold Nanorods and Enhanced Photothermal Therapy
Yanlei Liu,Meng Yang,Jingpu Zhang,Xiao Zhi,Chao Li,Chunlei Zhang,Fei Pan,Kan Wang,Yuming Yang,Jesus Martinez de la Fuentea,Daxiang Cui +10 more
TL;DR: The combination of gold nanorods with human iPS cells as a theranostic platform paves an alternative road for cancer theranostics and holds great promise for clinical translation in the near future.
Journal ArticleDOI
CXCL5-secreting pulmonary epithelial cells drive destructive neutrophilic inflammation in tuberculosis.
Geraldine Nouailles,Anca Dorhoi,Markus Koch,Jens Zerrahn,January Weiner rd,Kellen C. Faé,Frida Arrey,Stefanie Kuhlmann,Silke Bandermann,Delia Loewe,Hans-Joachim Mollenkopf,Alexis Vogelzang,Catherine Meyer-Schwesinger,Hans-Willi Mittrücker,Gayle K. McEwen,Stefan H. E. Kaufmann +15 more
TL;DR: It is found that TLR2-induced epithelial-derived CXCL5 is critical for PMN-driven destructive inflammation in pulmonary tuberculosis, and expression of genes encoding CXC chemokines in M. tuberculosis-infected murine lung tissue is analyzed.
Journal ArticleDOI
CXC chemokine receptors on human oligodendrocytes: implications for multiple sclerosis
TL;DR: The simultaneous expression of different CXC chemokine receptors on oligodendrocytes, and their ligands on astrocytic ligands around multiple sclerosis lesions, may bespeak novel functional roles for these immune system molecules in the recruitment of oligod endocrine cells and remyelination.
Journal ArticleDOI
Chemokine expression is associated with the accumulation of tumour associated macrophages (TAMs) and progression in human colorectal cancer
Charles Bailey,Rupert Negus,Alistair Morris,Paul Ziprin,Robert D. Goldin,Paola Allavena,David H. Peck,Ara Darzi +7 more
TL;DR: It is concluded that CCL2 induces the accumulation of tumour promoting TAMs in human colorectal cancer and represents a therapeutic target to modify the macrophage response and direct immune mediated therapy.
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Among CXCR3 Chemokines, IFN-γ-Inducible Protein of 10 kDa (CXC Chemokine Ligand (CXCL) 10) but Not Monokine Induced by IFN-γ (CXCL9) Imprints a Pattern for the Subsequent Development of Autoimmune Disease
Urs Christen,Dorian B. McGavern,Andrew D. Luster,Matthias von Herrath,Michael B. A. Oldstone +4 more
TL;DR: IP-10 expression was restricted to viruses infecting the pancreas and that are capable of causing diabetes, and virus-induced organ-specific autoimmune diseases may be dependent on virus tropism and its ability to alter the local milieu by selectively inducing chemokines that prepare the infected tissue for the subsequent destruction by the adaptive immune response.
References
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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
TL;DR: It is shown that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets, which are named central memory (TCM) and effector memory (TEM).
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Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
TL;DR: This is the first demonstration of the involvement of a G-protein-coupled chemokine receptor in neuronal cell migration and patterning in the central nervous system and may be important for designing strategies to block HIV entry into cells and for understanding mechanisms of pathogenesis in AIDS dementia.
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Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
Takashi Nagasawa,Seiichi Hirota,Kazunobu Tachibana,Nobuyuki Takakura,Shin-Ichi Nishikawa,Yukihiko Kitamura,Nobuaki Yoshida,Hitoshi Kikutani,Tadamitsu Kishimoto +8 more
TL;DR: It is shown that the chemokine PBSF/SDF-1 has several essential functions in development, including B-cell lymphopoiesis and bone-marrow myelopoiedis and a cardiac ventricular septal defect.
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CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.
Reinhold Förster,Andreas Schubel,Dagmar Breitfeld,Elisabeth Kremmer,Ingrid Renner-Müller,Eckhard Wolf,Martin Lipp +6 more
TL;DR: In this paper, the chemokine receptor CCR7 was identified as an important organizer of the primary immune response in mice, and severely delayed kinetics regarding the antibody response and lack contact sensitivity and delayed type hypersensitivity reactions.
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A new class of membrane-bound chemokine with a CX3C motif
J F Bazan,Kevin B. Bacon,Gary Hardiman,W Wang,K Soo,Devora L. Rossi,David R. Greaves,Albert Zlotnik,T J Schall +8 more
TL;DR: The structure, biochemical features, tissue distribution and chromosomal localization of CX3C chemokine all indicate that it represents a unique class of chemokines that may constitute part of the molecular control of leukocyte traffic at the endothelium.