Chemokines: A New Classification System and Their Role in Immunity
Albert Zlotnik,Osamu Yoshie +1 more
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This article is published in Immunity.The article was published on 2000-02-01 and is currently open access. It has received 3852 citations till now. The article focuses on the topics: CCL7.read more
Citations
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Cardiac Oxidative Stress and Inflammatory Cytokines Response after Myocardial Infarction
Margherita Neri,Vittorio Fineschi,Marco Di Paolo,Cristoforo Pomara,Irene Riezzo,Emanuela Turillazzi,Daniela Cerretani +6 more
TL;DR: The role of oxidative stress and pro-inflammatory cytokines response following acute myocardial infarction is examined and the inflammatory mechanisms of cardiac injury are explored.
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Chemokine expression by astrocytes plays a role in microglia/ macrophage activation and subsequent neurodegeneration in secondary progressive multiple sclerosis
TL;DR: Results suggest that MCP-1/CCL2 and IP-10/CXCL10 produced by astrocytes may activate astroCytes in an autocrine or paracrine manner and direct reactive gliosis followed by migration and activation of microglia/macrophages as effector cells in demyelinating lesions.
Journal ArticleDOI
IL‐1‐regulated responses in astrocytes: Relevance to injury and recovery
TL;DR: Data obtained with microarray technology are reviewed to provide an overview of the extent of changes induced in astrocytes by the cytokine IL‐1, and to suggest a role for microglia in the proper functioning of the neuronal network.
Journal Article
CXCR4 neutralization, a novel therapeutic approach for non-Hodgkin's lymphoma
Francesco Bertolini,Chiara Dell'Agnola,Patrizia Mancuso,Cristina Rabascio,Alessandra Burlini,Silvia Monestiroli,Alberto Gobbi,Giancarlo Pruneri,Giovanni Martinelli +8 more
TL;DR: The crucial role of CXCR4 in tumor cell extravasation was confirmed by the finding that CX CR4 neutralization before i.v. injection of Namalwa cells in NOD/SCID mice increased the number of cancer cells circulating 24 h after injection.
Journal ArticleDOI
CCL1-CCR8 interactions: an axis mediating the recruitment of T cells and Langerhans-type dendritic cells to sites of atopic skin inflammation.
Michael Gombert,Marie-Caroline Dieu-Nosjean,Franziska Winterberg,Erich Bünemann,Robert Kubitza,Ludivine Da Cunha,Anna Haahtela,Sari Lehtimäki,Anja Müller,Juliane Rieker,Stephan Meller,Andor Pivarcsi,Andrea Koreck,Wolf H. Fridman,Hans Walter Zentgraf,Hermann Pavenstädt,Ali Amara,Christophe Caux,Lajos Kemény,Harri Alenius,Antti Lauerma,Thomas Ruzicka,Albert Zlotnik,Bernhard Homey +23 more
TL;DR: The expression of the CC chemokine CCL1 is significantly and selectively up-regulated in atopic dermatitis in comparison to psoriasis, cutaneous lupus erythematosus, or normal skin.
References
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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
TL;DR: It is shown that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets, which are named central memory (TCM) and effector memory (TEM).
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Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
TL;DR: This is the first demonstration of the involvement of a G-protein-coupled chemokine receptor in neuronal cell migration and patterning in the central nervous system and may be important for designing strategies to block HIV entry into cells and for understanding mechanisms of pathogenesis in AIDS dementia.
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Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
Takashi Nagasawa,Seiichi Hirota,Kazunobu Tachibana,Nobuyuki Takakura,Shin-Ichi Nishikawa,Yukihiko Kitamura,Nobuaki Yoshida,Hitoshi Kikutani,Tadamitsu Kishimoto +8 more
TL;DR: It is shown that the chemokine PBSF/SDF-1 has several essential functions in development, including B-cell lymphopoiesis and bone-marrow myelopoiedis and a cardiac ventricular septal defect.
Journal ArticleDOI
CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.
Reinhold Förster,Andreas Schubel,Dagmar Breitfeld,Elisabeth Kremmer,Ingrid Renner-Müller,Eckhard Wolf,Martin Lipp +6 more
TL;DR: In this paper, the chemokine receptor CCR7 was identified as an important organizer of the primary immune response in mice, and severely delayed kinetics regarding the antibody response and lack contact sensitivity and delayed type hypersensitivity reactions.
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A new class of membrane-bound chemokine with a CX3C motif
J F Bazan,Kevin B. Bacon,Gary Hardiman,W Wang,K Soo,Devora L. Rossi,David R. Greaves,Albert Zlotnik,T J Schall +8 more
TL;DR: The structure, biochemical features, tissue distribution and chromosomal localization of CX3C chemokine all indicate that it represents a unique class of chemokines that may constitute part of the molecular control of leukocyte traffic at the endothelium.