Journal ArticleDOI
Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010
Christopher J L Murray,Theo Vos,Rafael Lozano,Mohsen Naghavi,Abraham D. Flaxman,Catherine Michaud,Majid Ezzati,Kenji Shibuya,Joshua A. Salomon,Safa Abdalla,Victor Aboyans,Jerry Abraham,Ilana N. Ackerman,Rakesh Aggarwal,Stephanie Y. Ahn,Mohammed K. Ali,Mohammad A. AlMazroa,Miriam Alvarado,H. Ross Anderson,Laurie M. Anderson,Kathryn G. Andrews,Charles Atkinson,Larry M. Baddour,Adil N. Bahalim,Suzanne Barker-Collo,Lope H Barrero,David Bartels,María-Gloria Basáñez,Amanda J Baxter,Michelle L. Bell,Emelia J. Benjamin,Derrick A Bennett,Eduardo Bernabé,Kavi Bhalla,Bishal Bhandari,Boris Bikbov,Aref A. Bin Abdulhak,Gretchen L. Birbeck,James A. Black,Hannah Blencowe,Jed D. Blore,Fiona M. Blyth,Ian Bolliger,Audrey Bonaventure,Soufiane Boufous,Rupert R A Bourne,Michel Boussinesq,Tasanee Braithwaite,Carol Brayne,Lisa Bridgett,Simon Brooker,Peter Brooks,Traolach S. Brugha,Claire Bryan-Hancock,Chiara Bucello,Rachelle Buchbinder,Geoffrey Buckle,Christine M. Budke,Michael Burch,Peter Burney,Roy Burstein,Bianca Calabria,Benjamin L. Campbell,Charles E. Canter,Hélène Carabin,Jonathan R. Carapetis,Loreto Carmona,Claudia Cella,Fiona J Charlson,Honglei Chen,Andrew T. A. Cheng,David Chou,Sumeet S. Chugh,Luc E. Coffeng,Steven D. Colan,Samantha M. Colquhoun,K. Ellicott Colson,John R. Condon,Myles Connor,Myles Connor,Myles Connor,Leslie T. Cooper,Matthew A. Corriere,Monica Cortinovis,Karen Courville De Vaccaro,William G. Couser,Benjamin C Cowie,Michael H. Criqui,Marita Cross,Kaustubh Dabhadkar,Manu Dahiya,Nabila Dahodwala,James Damsere-Derry,Goodarz Danaei,Adrian Davis,Diego De Leo,Louisa Degenhardt,Louisa Degenhardt,Robert P. Dellavalle,Allyne Delossantos,Julie O. Denenberg,Sarah Derrett,Don C. Des Jarlais,Samath D Dharmaratne,Samath D Dharmaratne,Mukesh Dherani,Cesar Diaz-Torne,Helen Dolk,E. Ray Dorsey,Tim Driscoll,Herbert C. Duber,Beth E. Ebel,Karen Edmond,Alexis Elbaz,S. Ali,Holly E. Erskine,Patricia J. Erwin,Patricia Espindola,Stalin E. Ewoigbokhan,Farshad Farzadfar,Valery L. Feigin,David T. Felson,Alize J. Ferrari,Cleusa P. Ferri,Eric M. Fèvre,Mariel M. Finucane,Seth Flaxman,Louise Flood,Kyle J Foreman,Mohammad H. Forouzanfar,F.G.R. Fowkes,Marlene Fransen,Michael Freeman,Belinda J. Gabbe,Sherine E. Gabriel,Emmanuela Gakidou,Hammad A. Ganatra,Bianca Garcia,Flavio Gaspari,Richard F. Gillum,Gerhard Gmel,Diego Gonzalez-Medina,Richard A. Gosselin,Rebecca Grainger,Bridget F. Grant,Justina Groeger,Francis Guillemin,David Gunnell,R Gupta,Juanita A. Haagsma,Holly Hagan,Yara A. Halasa,Wayne Hall,Diana Haring,Josep Maria Haro,James Harrison,Rasmus Havmoeller,Rasmus Havmoeller,Roderick J. Hay,Hideki Higashi,Christopher Hill,Bruno Hoen,Howard J. Hoffman,Peter J. Hotez,Damian G Hoy,John J Huang,Sydney E. Ibeanusi,Kathryn H. Jacobsen,Spencer L. James,Deborah Jarvis,Rashmi Jasrasaria,Sudha Jayaraman,Nicole E. Johns,Jost B. Jonas,Ganesan Karthikeyan,Nicholas J Kassebaum,Norito Kawakami,Andre Keren,Jon Paul Khoo,Charles H. King,Lisa M. Knowlton,Olive Kobusingye,Olive Kobusingye,Adofo Koranteng,Rita Krishnamurthi,Francine Laden,Ratilal Lalloo,Laura L Laslett,Tim Lathlean,Janet L Leasher,Yong Yi Lee,James Leigh,Daphna Levinson,Stephen S Lim,Elizabeth S Limb,John K Lin,Michael S Lipnick,Steven E. Lipshultz,Wei Liu,Maria Loane,Summer Lockett Ohno,Ronan A Lyons,Jacqueline Mabweijano,Michael F. MacIntyre,Reza Malekzadeh,Leslie Mallinger,Sivabalan Manivannan,Wagner Marcenes,Lyn March,David J. Margolis,Guy B. Marks,Robin Marks,Akira Matsumori,Richard Matzopoulos,Richard Matzopoulos,Bongani M. Mayosi,John H. McAnulty,Mary M. McDermott,Neil McGill,John J. McGrath,María Elena Medina-Mora,Michele Meltzer,Ziad A. Memish,George A. Mensah,Tony R. Merriman,Ana-Claire Meyer,Valeria Miglioli,Matthew J. Miller,Ted R. Miller,Philip B. Mitchell,Charles Mock,Ana Olga Mocumbi,Terrie E. Moffitt,Ali A. Mokdad,Lorenzo Monasta,Marcella Montico,Maziar Moradi-Lakeh,Andrew E. Moran,Lidia Morawska,Rintaro Mori,Michele E. Murdoch,Michael K Mwaniki,Kovin Naidoo,M. Nathan Nair,Luigi Naldi,K.M. Venkat Narayan,Paul K. Nelson,Robert G. Nelson,Michael C. Nevitt,Charles R. Newton,Sandra Nolte,Paul Norman,Rosana E. Norman,Martin O'Donnell,Simon J. O’Hanlon,Casey Olives,Saad B. Omer,Katrina F Ortblad,Richard H. Osborne,Doruk Ozgediz,Andrew Page,Bishnu Pahari,Jeyaraj D Pandian,Andrea Panozo Rivero,Scott B. Patten,Neil Pearce,Rogelio Perez Padilla,Fernando Perez-Ruiz,Norberto Perico,Konrad Pesudovs,David Phillips,Michael Phillips,Kelsey Pierce,Sébastien D. S. Pion,Guilherme V. Polanczyk,Suzanne Polinder,C. Arden Pope,Svetlana Popova,Esteban Porrini,Farshad Pourmalek,Martin Prince,Rachel L. Pullan,Kapa D. Ramaiah,Dharani Ranganathan,Homie Razavi,Mathilda Regan,Jürgen Rehm,David B. Rein,G. Remuzzi,Kathryn Richardson,Frederick P. Rivara,Thomas Roberts,Carolyn Robinson,Felipe Rodriguez De Leòn,Luca Ronfani,Robin Room,Robin Room,Lisa C. Rosenfeld,Lesley Rushton,Ralph L. Sacco,Sukanta Saha,Uchechukwu Sampson,Lidia Sanchez-Riera,Ella Sanman,David C. Schwebel,James Scott,Maria Segui-Gomez,Saeid Shahraz,Donald S. Shepard,Hwashin Shin,Rupak Shivakoti,Donald H. Silberberg,David Singh,Gitanjali M Singh,Jasvinder A. Singh,Jessica Singleton,David A. Sleet,Karen Sliwa,Emma Smith,Jennifer L. Smith,Nicolas J. C. Stapelberg,Andrew C Steer,Timothy J. Steiner,Wilma A. Stolk,Lars Jacob Stovner,Christopher R. Sudfeld,Sana Syed,Giorgio Tamburlini,Mohammad Tavakkoli,Hugh R. Taylor,Jennifer A. Taylor,William J. Taylor,Bernadette Thomas,W. Murray Thomson,George D. Thurston,Imad M. Tleyjeh,Marcello Tonelli,Jeffrey A. Towbin,Thomas Truelsen,Miltiadis K. Tsilimbaris,Clotilde Ubeda,Eduardo A. Undurraga,Marieke J. van der Werf,Jim van Os,Monica S. Vavilala,Narayanaswamy Venketasubramanian,Mengru Wang,Wenzhi Wang,Kerrianne Watt,David J. Weatherall,Martin A. Weinstock,Robert G. Weintraub,Marc G. Weisskopf,Myrna M. Weissman,Richard A. White,Harvey Whiteford,Natasha Wiebe,Steven T. Wiersma,James D. Wilkinson,Hywel C Williams,Sean R.M. Williams,Emma Witt,Frederick Wolfe,Anthony D. Woolf,Sarah Wulf,Pon Hsiu Yeh,Anita K. M. Zaidi,Zhi Jie Zheng,David Zonies,Alan D. Lopez +369 more
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TLDR
The results for 1990 and 2010 supersede all previously published Global Burden of Disease results and highlight the importance of understanding local burden of disease and setting goals and targets for the post-2015 agenda taking such patterns into account.About:
This article is published in The Lancet.The article was published on 2012-12-15. It has received 6861 citations till now. The article focuses on the topics: Disease burden & Disability-adjusted life year.read more
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Journal ArticleDOI
Comparative Effectiveness of Tai Chi Versus Physical Therapy for Knee Osteoarthritis: A Randomized Trial
Chenchen Wang,Christopher H. Schmid,Maura D. Iversen,William F. Harvey,Roger A. Fielding,Jeffrey B. Driban,Lori Lyn Price,John B. Wong,Kieran F. Reid,Ramel Rones,Timothy E. McAlindon +10 more
TL;DR: The primary goal of this study was to compare the effectiveness of Tai Chi versus a physical therapy regimen among a large sample of patients with symptomatic and radiographic knee osteoarthritis who were seen in the clinical setting and followed for 12 months.
Journal ArticleDOI
The winding road to regenerating the human heart
TL;DR: Focusing on the delivery of human stem cell-derived cardiomyocytes, current experimental strategies in the field will be discussed as well as their clinical translation potential, and certain challenges must be overcome for this technique to be successful in the clinics.
Journal ArticleDOI
Global and regional trends in particulate air pollution and attributable health burden over the past 50 years
Edward W. Butt,Steven T. Turnock,Richard Rigby,Carly Reddington,M. Yoshioka,Jill S. Johnson,L. A. Regayre,Kirsty J. Pringle,Graham Mann,Dominick V. Spracklen +9 more
TL;DR: In this article, the authors used the HadGEM3-UKCA coupled chemistry-climate model, integrated exposure-response relationships, demographic and background disease data to provide the first estimate of the changes in global and regional ambient PM2.5 concentrations and attributable health burdens over the period 1960 to 2009.
Journal ArticleDOI
Loss of sclerostin promotes osteoarthritis in mice via β-catenin-dependent and -independent Wnt pathways
Wafa Bouaziz,Thomas Funck-Brentano,Hilène Lin,Caroline Marty,Hang-Korng Ea,Eric Haÿ,Martine Cohen-Solal +6 more
TL;DR: Sclerostin may play an important role in maintaining cartilage integrity in OA and inhibited both Wnt canonical and non-canonical JNK pathways in chondrocytes, thus preserving metabolism.
Journal ArticleDOI
Opportunities and challenges in modeling human brain disorders in transgenic primates
Charles Jennings,Rogier Landman,Rogier Landman,Yang Zhou,Jitendra Sharma,Julia B. Hyman,J. Anthony Movshon,Zilong Qiu,Angela C. Roberts,Anna W. Roe,Xiaoqin Wang,Huihui Zhou,Liping Wang,Feng Zhang,Feng Zhang,Robert Desimone,Guoping Feng,Guoping Feng +17 more
TL;DR: The main focus is on the creation of new primate disease models for understanding the pathological mechanisms of brain disorders and for developing new approaches to effective treatment, but it is emphasized that primate genetic models have great potential to address many fundamental questions about brain function.
References
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Journal ArticleDOI
Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010
Rafael Lozano,Mohsen Naghavi,Kyle J Foreman,Stephen S Lim,Kenji Shibuya,Victor Aboyans,Jerry Abraham,Tim Adair,Rakesh Aggarwal,Stephanie Y. Ahn,Mohammad A. AlMazroa,Miriam Alvarado,H. Ross Anderson,Laurie M. Anderson,Kathryn G. Andrews,Charles Atkinson,Larry M. Baddour,Suzanne Barker-Collo,David Bartels,Michelle L. Bell,Emelia J. Benjamin,Derrick A Bennett,Kavi Bhalla,Boris Bikbov,Aref A. Bin Abdulhak,Gretchen L. Birbeck,Fiona M. Blyth,Ian Bolliger,Soufiane Boufous,Chiara Bucello,Michael Burch,Peter Burney,Jonathan R. Carapetis,Honglei Chen,David Chou,Sumeet S. Chugh,Luc E. Coffeng,Steven D. Colan,Samantha M. Colquhoun,K. Ellicott Colson,John R. Condon,Myles Connor,Myles Connor,Leslie T. Cooper,Matthew A. Corriere,Monica Cortinovis,Karen Courville De Vaccaro,William G. Couser,Benjamin C Cowie,Michael H. Criqui,Marita Cross,Kaustubh Dabhadkar,Nabila Dahodwala,Diego De Leo,Louisa Degenhardt,Allyne Delossantos,Julie O. Denenberg,Don C. Des Jarlais,Samath D Dharmaratne,Samath D Dharmaratne,E. Ray Dorsey,Tim Driscoll,Herbert C. Duber,Beth E. Ebel,Patricia J. Erwin,Patricia Espindola,Majid Ezzati,Valery L. Feigin,Abraham D. Flaxman,Mohammad H. Forouzanfar,F.G.R. Fowkes,Richard C. Franklin,Marlene Fransen,Michael Freeman,Sherine E. Gabriel,Emmanuela Gakidou,Flavio Gaspari,Richard F. Gillum,Diego Gonzalez-Medina,Yara A. Halasa,Diana Haring,James Harrison,Rasmus Havmoeller,Rasmus Havmoeller,Roderick J. Hay,Bruno Hoen,Peter J. Hotez,Damian G Hoy,Kathryn H. Jacobsen,Spencer L. James,Rashmi Jasrasaria,Sudha Jayaraman,Nicole E. Johns,Ganesan Karthikeyan,Nicholas J Kassebaum,Andre Keren,Jon Paul Khoo,Lisa M. Knowlton,Olive Kobusingye,Adofo Koranteng,Rita Krishnamurthi,Michael S Lipnick,Steven E. Lipshultz,Summer Lockett Ohno,Jacqueline Mabweijano,Jacqueline Mabweijano,Michael F. Macintyre,Leslie Mallinger,Lyn March,Guy B. Marks,Robin Marks,Akira Matsumori,Richard Matzopoulos,Richard Matzopoulos,Bongani M. Mayosi,John H. McAnulty,Mary M. McDermott,John J. McGrath,Ziad A. Memish,George A. Mensah,Tony R. Merriman,Catherine Michaud,Matthew J. Miller,Ted R. Miller,Charles Mock,Ana Olga Mocumbi,Ali A. Mokdad,Andrew E. Moran,Kim Mulholland,M. Nathan Nair,Luigi Naldi,K.M. Venkat Narayan,Kiumarss Nasseri,Paul Norman,Martin O'Donnell,Saad B. Omer,Katrina F Ortblad,Richard H. Osborne,Doruk Ozgediz,Bishnu Pahari,Jeyaraj D Pandian,Andrea Panozo Rivero,Rogelio Perez Padilla,Fernando Perez-Ruiz,Norberto Perico,David Phillips,Kelsey Pierce,C. Arden Pope,Esteban Porrini,Farshad Pourmalek,Murugesan Raju,Dharani Ranganathan,Jürgen Rehm,David B. Rein,G. Remuzzi,Frederick P. Rivara,Thomas Roberts,Felipe Rodriguez De Leòn,Lisa C. Rosenfeld,Lesley Rushton,Ralph L. Sacco,Joshua A. Salomon,Uchechukwu Sampson,Ella Sanman,David C. Schwebel,Maria Segui-Gomez,Donald S. Shepard,David Singh,Jessica Singleton,Karen Sliwa,Emma Smith,Andrew C Steer,Jennifer A. Taylor,Bernadette Thomas,Imad M. Tleyjeh,Jeffrey A. Towbin,Thomas Truelsen,Eduardo A. Undurraga,Narayanaswamy Venketasubramanian,Lakshmi Vijayakumar,Theo Vos,Gregory R. Wagner,Mengru Wang,Wenzhi Wang,Kerrianne Watt,Martin A. Weinstock,Robert G. Weintraub,James D. Wilkinson,Anthony D. Woolf,Sarah Wulf,Pon Hsiu Yeh,Paul S. F. Yip,Azadeh Zabetian,Zhi Jie Zheng,Alan D. Lopez,Christopher J L Murray +195 more
TL;DR: The Global Burden of Diseases, Injuries, and Risk Factors Study 2010 aimed to estimate annual deaths for the world and 21 regions between 1980 and 2010 for 235 causes, with uncertainty intervals (UIs), separately by age and sex, using the Cause of Death Ensemble model.
Book
The global burden of disease: a comprehensive assessment of mortality and disability from diseases injuries and risk factors in 1990 and projected to 2020.
TL;DR: This is the first in a planned series of 10 volumes that will attempt to "summarize epidemiological knowledge about all major conditions and most risk factors" and use historical trends in main determinants to project mortality and disease burden forward to 2020.
Journal ArticleDOI
Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010
Theo Vos,Abraham D. Flaxman,Mohsen Naghavi,Rafael Lozano,Catherine Michaud,Majid Ezzati,Kenji Shibuya,Joshua A. Salomon,Safa Abdalla,Victor Aboyans,Jerry Abraham,Ilana N. Ackerman,Rakesh Aggarwal,Stephanie Y. Ahn,Mohammed K. Ali,Mohammad A. AlMazroa,Miriam Alvarado,H. Ross Anderson,Laurie M. Anderson,Kathryn G. Andrews,Charles Atkinson,Larry M. Baddour,Adil N. Bahalim,Suzanne Barker-Collo,Lope H Barrero,David Bartels,María-Gloria Basáñez,Amanda J Baxter,Michelle L. Bell,Emelia J. Benjamin,Derrick A Bennett,Eduardo Bernabé,Kavi Bhalla,Bishal Bhandari,Boris Bikbov,Aref A. Bin Abdulhak,Gretchen L. Birbeck,James A. Black,Hannah Blencowe,Jed D. Blore,Fiona M. Blyth,Ian Bolliger,Audrey Bonaventure,Soufiane Boufous,Rupert R A Bourne,Michel Boussinesq,Tasanee Braithwaite,Carol Brayne,Lisa Bridgett,Simon Brooker,Peter Brooks,Traolach S. Brugha,Claire Bryan-Hancock,Chiara Bucello,Rachelle Buchbinder,Geoffrey Buckle,Christine M. Budke,Michael Burch,Peter Burney,Roy Burstein,Bianca Calabria,Benjamin L. Campbell,Charles E. Canter,Hélène Carabin,Jonathan R. Carapetis,Loreto Carmona,Claudia Cella,Fiona J Charlson,Honglei Chen,Andrew T. A. Cheng,David Chou,Sumeet S. Chugh,Luc E. Coffeng,Steven D. Colan,Samantha M. Colquhoun,K. Ellicott Colson,John R. Condon,Myles Connor,Myles Connor,Myles Connor,Leslie T. Cooper,Matthew A. Corriere,Monica Cortinovis,Karen Courville De Vaccaro,William G. Couser,Benjamin C Cowie,Michael H. Criqui,Marita Cross,Kaustubh Dabhadkar,Manu Dahiya,Nabila Dahodwala,James Damsere-Derry,Goodarz Danaei,Adrian Davis,Diego De Leo,Louisa Degenhardt,Robert P. Dellavalle,Allyne Delossantos,Julie O. Denenberg,Sarah Derrett,Don C. Des Jarlais,Samath D Dharmaratne,Samath D Dharmaratne,Mukesh Dherani,Cesar Diaz-Torne,Helen Dolk,E. Ray Dorsey,Tim Driscoll,Herbert C. Duber,Beth E. Ebel,Karen Edmond,Alexis Elbaz,S. Ali,Holly E. Erskine,Patricia J. Erwin,Patricia Espindola,Stalin E. Ewoigbokhan,Farshad Farzadfar,Valery L. Feigin,David T. Felson,Alize J. Ferrari,Cleusa P. Ferri,Eric M. Fèvre,Mariel M. Finucane,Seth Flaxman,Louise Flood,Kyle J Foreman,Mohammad H. Forouzanfar,F.G.R. Fowkes,Richard C. Franklin,Richard C. Franklin,Marlene Fransen,Michael Freeman,Belinda J. Gabbe,Sherine E. Gabriel,Emmanuela Gakidou,Hammad A. Ganatra,Bianca Garcia,Flavio Gaspari,Richard F. Gillum,Gerhard Gmel,Richard A. Gosselin,Rebecca Grainger,Justina Groeger,Francis Guillemin,David Gunnell,R Gupta,Juanita A. Haagsma,Holly Hagan,Yara A. Halasa,Wayne Hall,Diana Haring,Josep Maria Haro,James Harrison,Rasmus Havmoeller,Roderick J. Hay,Hideki Higashi,Christopher Hill,Bruno Hoen,Howard J. Hoffman,Peter J. Hotez,Damian G Hoy,John J Huang,Sydney E. Ibeanusi,Kathryn H. Jacobsen,Spencer L. James,Deborah Jarvis,Rashmi Jasrasaria,Sudha Jayaraman,Nicole E. Johns,Jost B. Jonas,Ganesan Karthikeyan,Nicholas J Kassebaum,Norito Kawakami,Andre Keren,Jon Paul Khoo,Charles H. King,Lisa M. Knowlton,Olive Kobusingye,Olive Kobusingye,Adofo Koranteng,Rita Krishnamurthi,Ratilal Lalloo,Laura L Laslett,Tim Lathlean,Janet L Leasher,Yong Yi Lee,James Leigh,Stephen S Lim,Elizabeth S Limb,John K Lin,Michael S Lipnick,Steven E. Lipshultz,Wei Liu,Maria Loane,Summer Lockett Ohno,Ronan A Lyons,Jixiang Ma,Jacqueline Mabweijano,Michael F. MacIntyre,Reza Malekzadeh,Leslie Mallinger,Sivabalan Manivannan,Wagner Marcenes,Lyn March,David J. Margolis,Guy B. Marks,Robin Marks,Akira Matsumori,Richard Matzopoulos,Richard Matzopoulos,Bongani M. Mayosi,John H. McAnulty,Mary M. McDermott,Neil McGill,John J. McGrath,María Elena Medina-Mora,Michele Meltzer,Ziad A. Memish,George A. Mensah,Tony R. Merriman,Ana-Claire Meyer,Valeria Miglioli,Matthew J. Miller,Ted R. Miller,Philip B. Mitchell,Ana Olga Mocumbi,Terrie E. Moffitt,Ali A. Mokdad,Lorenzo Monasta,Marcella Montico,Maziar Moradi-Lakeh,Andrew E. Moran,Lidia Morawska,Rintaro Mori,Michele E. Murdoch,Michael K Mwaniki,Kovin Naidoo,M. Nathan Nair,Luigi Naldi,K.M. Venkat Narayan,Paul K. Nelson,Robert G. Nelson,Michael C. Nevitt,Charles R. Newton,Sandra Nolte,Paul Norman,Rosana E. Norman,Martin O'Donnell,Simon J. O’Hanlon,Casey Olives,Saad B. Omer,Katrina F Ortblad,Richard H. Osborne,Doruk Ozgediz,Andrew Page,Bishnu Pahari,Jeyaraj D Pandian,Andrea Panozo Rivero,Scott B. Patten,Neil Pearce,Rogelio Perez Padilla,Fernando Perez-Ruiz,Norberto Perico,Konrad Pesudovs,David Phillips,Michael R. Phillips,Kelsey Pierce,Sébastien D. S. Pion,Guilherme V. Polanczyk,Suzanne Polinder,C. Arden Pope,Svetlana Popova,Esteban Porrini,Farshad Pourmalek,Martin Prince,Rachel L. Pullan,Kapa D. Ramaiah,Dharani Ranganathan,Homie Razavi,Mathilda Regan,Jürgen Rehm,David B. Rein,G. Remuzzi,Kathryn Richardson,Frederick P. Rivara,Thomas Roberts,Carolyn Robinson,Felipe Rodriguez De Leòn,Luca Ronfani,Robin Room,Lisa C. Rosenfeld,Lesley Rushton,Ralph L. Sacco,Sukanta Saha,Uchechukwu Sampson,Lidia Sanchez-Riera,Ella Sanman,David C. Schwebel,James Scott,Maria Segui-Gomez,Saeid Shahraz,Donald S. Shepard,Hwashin Shin,Rupak Shivakoti,Donald H. Silberberg,David Singh,Gitanjali M Singh,Jasvinder A. Singh,Jessica Singleton,David A. Sleet,Karen Sliwa,Emma Smith,Jennifer L. Smith,Nicolas J. C. Stapelberg,Andrew C Steer,Timothy J. Steiner,Wilma A. Stolk,Lars Jacob Stovner,Christopher R. Sudfeld,Sana Syed,Giorgio Tamburlini,Mohammad Tavakkoli,Hugh R. Taylor,Jennifer A. Taylor,William J. Taylor,Bernadette Thomas,W. Murray Thomson,George D. Thurston,Imad M. Tleyjeh,Marcello Tonelli,Jeffrey A. Towbin,Thomas Truelsen,Miltiadis K. Tsilimbaris,Clotilde Ubeda,Eduardo A. Undurraga,Marieke J. van der Werf,Jim van Os,Monica S. Vavilala,Narayanaswamy Venketasubramanian,Mengru Wang,Wenzhi Wang,Kerrianne Watt,David Weatherall,Martin A. Weinstock,Robert G. Weintraub,Marc G. Weisskopf,Myrna M. Weissman,Richard A. White,Harvey Whiteford,Steven T. Wiersma,James D. Wilkinson,Hywel C Williams,Sean R.M. Williams,Emma Witt,Frederick Wolfe,Anthony D. Woolf,Sarah Wulf,Pon Hsiu Yeh,Anita K. M. Zaidi,Zhi Jie Zheng,David Zonies,Alan D. Lopez,Christopher J L Murray +363 more
TL;DR: Prevalence and severity of health loss were weakly correlated and age-specific prevalence of YLDs increased with age in all regions and has decreased slightly from 1990 to 2010, but population growth and ageing have increased YLD numbers and crude rates over the past two decades.
Journal ArticleDOI
Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study
TL;DR: The three leading contributors to the burden of disease are communicable and perinatal disorders affecting children, and the substantial burdens of neuropsychiatric disorders and injuries are under-recognised.
Related Papers (5)
Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010
Rafael Lozano,Mohsen Naghavi,Kyle J Foreman,Stephen S Lim,Kenji Shibuya,Victor Aboyans,Jerry Abraham,Tim Adair,Rakesh Aggarwal,Stephanie Y. Ahn,Mohammad A. AlMazroa,Miriam Alvarado,H. Ross Anderson,Laurie M. Anderson,Kathryn G. Andrews,Charles Atkinson,Larry M. Baddour,Suzanne Barker-Collo,David Bartels,Michelle L. Bell,Emelia J. Benjamin,Derrick A Bennett,Kavi Bhalla,Boris Bikbov,Aref A. Bin Abdulhak,Gretchen L. Birbeck,Fiona M. Blyth,Ian Bolliger,Soufiane Boufous,Chiara Bucello,Michael Burch,Peter Burney,Jonathan R. Carapetis,Honglei Chen,David Chou,Sumeet S. Chugh,Luc E. Coffeng,Steven D. Colan,Samantha M. Colquhoun,K. Ellicott Colson,John R. Condon,Myles Connor,Myles Connor,Leslie T. Cooper,Matthew A. Corriere,Monica Cortinovis,Karen Courville De Vaccaro,William G. Couser,Benjamin C Cowie,Michael H. Criqui,Marita Cross,Kaustubh Dabhadkar,Nabila Dahodwala,Diego De Leo,Louisa Degenhardt,Allyne Delossantos,Julie O. Denenberg,Don C. Des Jarlais,Samath D Dharmaratne,Samath D Dharmaratne,E. Ray Dorsey,Tim Driscoll,Herbert C. Duber,Beth E. Ebel,Patricia J. Erwin,Patricia Espindola,Majid Ezzati,Valery L. Feigin,Abraham D. Flaxman,Mohammad H. Forouzanfar,F.G.R. Fowkes,Richard C. Franklin,Marlene Fransen,Michael Freeman,Sherine E. Gabriel,Emmanuela Gakidou,Flavio Gaspari,Richard F. Gillum,Diego Gonzalez-Medina,Yara A. Halasa,Diana Haring,James Harrison,Rasmus Havmoeller,Rasmus Havmoeller,Roderick J. Hay,Bruno Hoen,Peter J. Hotez,Damian G Hoy,Kathryn H. Jacobsen,Spencer L. James,Rashmi Jasrasaria,Sudha Jayaraman,Nicole E. Johns,Ganesan Karthikeyan,Nicholas J Kassebaum,Andre Keren,Jon Paul Khoo,Lisa M. Knowlton,Olive Kobusingye,Adofo Koranteng,Rita Krishnamurthi,Michael S Lipnick,Steven E. Lipshultz,Summer Lockett Ohno,Jacqueline Mabweijano,Jacqueline Mabweijano,Michael F. Macintyre,Leslie Mallinger,Lyn March,Guy B. Marks,Robin Marks,Akira Matsumori,Richard Matzopoulos,Richard Matzopoulos,Bongani M. Mayosi,John H. McAnulty,Mary M. McDermott,John J. McGrath,Ziad A. Memish,George A. Mensah,Tony R. Merriman,Catherine Michaud,Matthew J. Miller,Ted R. Miller,Charles Mock,Ana Olga Mocumbi,Ali A. Mokdad,Andrew E. Moran,Kim Mulholland,M. Nathan Nair,Luigi Naldi,K.M. Venkat Narayan,Kiumarss Nasseri,Paul Norman,Martin O'Donnell,Saad B. Omer,Katrina F Ortblad,Richard H. Osborne,Doruk Ozgediz,Bishnu Pahari,Jeyaraj D Pandian,Andrea Panozo Rivero,Rogelio Perez Padilla,Fernando Perez-Ruiz,Norberto Perico,David Phillips,Kelsey Pierce,C. Arden Pope,Esteban Porrini,Farshad Pourmalek,Murugesan Raju,Dharani Ranganathan,Jürgen Rehm,David B. Rein,G. Remuzzi,Frederick P. Rivara,Thomas Roberts,Felipe Rodriguez De Leòn,Lisa C. Rosenfeld,Lesley Rushton,Ralph L. Sacco,Joshua A. Salomon,Uchechukwu Sampson,Ella Sanman,David C. Schwebel,Maria Segui-Gomez,Donald S. Shepard,David Singh,Jessica Singleton,Karen Sliwa,Emma Smith,Andrew C Steer,Jennifer A. Taylor,Bernadette Thomas,Imad M. Tleyjeh,Jeffrey A. Towbin,Thomas Truelsen,Eduardo A. Undurraga,Narayanaswamy Venketasubramanian,Lakshmi Vijayakumar,Theo Vos,Gregory R. Wagner,Mengru Wang,Wenzhi Wang,Kerrianne Watt,Martin A. Weinstock,Robert G. Weintraub,James D. Wilkinson,Anthony D. Woolf,Sarah Wulf,Pon Hsiu Yeh,Paul S. F. Yip,Azadeh Zabetian,Zhi Jie Zheng,Alan D. Lopez,Christopher J L Murray +195 more
Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010
Theo Vos,Abraham D. Flaxman,Mohsen Naghavi,Rafael Lozano,Catherine Michaud,Majid Ezzati,Kenji Shibuya,Joshua A. Salomon,Safa Abdalla,Victor Aboyans,Jerry Abraham,Ilana N. Ackerman,Rakesh Aggarwal,Stephanie Y. Ahn,Mohammed K. Ali,Mohammad A. AlMazroa,Miriam Alvarado,H. Ross Anderson,Laurie M. Anderson,Kathryn G. Andrews,Charles Atkinson,Larry M. Baddour,Adil N. Bahalim,Suzanne Barker-Collo,Lope H Barrero,David Bartels,María-Gloria Basáñez,Amanda J Baxter,Michelle L. Bell,Emelia J. Benjamin,Derrick A Bennett,Eduardo Bernabé,Kavi Bhalla,Bishal Bhandari,Boris Bikbov,Aref A. Bin Abdulhak,Gretchen L. Birbeck,James A. Black,Hannah Blencowe,Jed D. Blore,Fiona M. Blyth,Ian Bolliger,Audrey Bonaventure,Soufiane Boufous,Rupert R A Bourne,Michel Boussinesq,Tasanee Braithwaite,Carol Brayne,Lisa Bridgett,Simon Brooker,Peter Brooks,Traolach S. Brugha,Claire Bryan-Hancock,Chiara Bucello,Rachelle Buchbinder,Geoffrey Buckle,Christine M. Budke,Michael Burch,Peter Burney,Roy Burstein,Bianca Calabria,Benjamin L. Campbell,Charles E. Canter,Hélène Carabin,Jonathan R. Carapetis,Loreto Carmona,Claudia Cella,Fiona J Charlson,Honglei Chen,Andrew T. A. Cheng,David Chou,Sumeet S. Chugh,Luc E. Coffeng,Steven D. Colan,Samantha M. Colquhoun,K. Ellicott Colson,John R. Condon,Myles Connor,Myles Connor,Myles Connor,Leslie T. Cooper,Matthew A. Corriere,Monica Cortinovis,Karen Courville De Vaccaro,William G. Couser,Benjamin C Cowie,Michael H. Criqui,Marita Cross,Kaustubh Dabhadkar,Manu Dahiya,Nabila Dahodwala,James Damsere-Derry,Goodarz Danaei,Adrian Davis,Diego De Leo,Louisa Degenhardt,Robert P. Dellavalle,Allyne Delossantos,Julie O. Denenberg,Sarah Derrett,Don C. Des Jarlais,Samath D Dharmaratne,Samath D Dharmaratne,Mukesh Dherani,Cesar Diaz-Torne,Helen Dolk,E. Ray Dorsey,Tim Driscoll,Herbert C. Duber,Beth E. Ebel,Karen Edmond,Alexis Elbaz,S. Ali,Holly E. Erskine,Patricia J. Erwin,Patricia Espindola,Stalin E. Ewoigbokhan,Farshad Farzadfar,Valery L. Feigin,David T. Felson,Alize J. Ferrari,Cleusa P. Ferri,Eric M. Fèvre,Mariel M. Finucane,Seth Flaxman,Louise Flood,Kyle J Foreman,Mohammad H. Forouzanfar,F.G.R. Fowkes,Richard C. Franklin,Richard C. Franklin,Marlene Fransen,Michael Freeman,Belinda J. Gabbe,Sherine E. Gabriel,Emmanuela Gakidou,Hammad A. Ganatra,Bianca Garcia,Flavio Gaspari,Richard F. Gillum,Gerhard Gmel,Richard A. Gosselin,Rebecca Grainger,Justina Groeger,Francis Guillemin,David Gunnell,R Gupta,Juanita A. Haagsma,Holly Hagan,Yara A. Halasa,Wayne Hall,Diana Haring,Josep Maria Haro,James Harrison,Rasmus Havmoeller,Roderick J. Hay,Hideki Higashi,Christopher Hill,Bruno Hoen,Howard J. Hoffman,Peter J. Hotez,Damian G Hoy,John J Huang,Sydney E. Ibeanusi,Kathryn H. Jacobsen,Spencer L. James,Deborah Jarvis,Rashmi Jasrasaria,Sudha Jayaraman,Nicole E. Johns,Jost B. Jonas,Ganesan Karthikeyan,Nicholas J Kassebaum,Norito Kawakami,Andre Keren,Jon Paul Khoo,Charles H. King,Lisa M. Knowlton,Olive Kobusingye,Olive Kobusingye,Adofo Koranteng,Rita Krishnamurthi,Ratilal Lalloo,Laura L Laslett,Tim Lathlean,Janet L Leasher,Yong Yi Lee,James Leigh,Stephen S Lim,Elizabeth S Limb,John K Lin,Michael S Lipnick,Steven E. Lipshultz,Wei Liu,Maria Loane,Summer Lockett Ohno,Ronan A Lyons,Jixiang Ma,Jacqueline Mabweijano,Michael F. MacIntyre,Reza Malekzadeh,Leslie Mallinger,Sivabalan Manivannan,Wagner Marcenes,Lyn March,David J. Margolis,Guy B. Marks,Robin Marks,Akira Matsumori,Richard Matzopoulos,Richard Matzopoulos,Bongani M. Mayosi,John H. McAnulty,Mary M. McDermott,Neil McGill,John J. McGrath,María Elena Medina-Mora,Michele Meltzer,Ziad A. Memish,George A. Mensah,Tony R. Merriman,Ana-Claire Meyer,Valeria Miglioli,Matthew J. Miller,Ted R. Miller,Philip B. Mitchell,Ana Olga Mocumbi,Terrie E. Moffitt,Ali A. Mokdad,Lorenzo Monasta,Marcella Montico,Maziar Moradi-Lakeh,Andrew E. Moran,Lidia Morawska,Rintaro Mori,Michele E. Murdoch,Michael K Mwaniki,Kovin Naidoo,M. Nathan Nair,Luigi Naldi,K.M. Venkat Narayan,Paul K. Nelson,Robert G. Nelson,Michael C. Nevitt,Charles R. Newton,Sandra Nolte,Paul Norman,Rosana E. Norman,Martin O'Donnell,Simon J. O’Hanlon,Casey Olives,Saad B. Omer,Katrina F Ortblad,Richard H. Osborne,Doruk Ozgediz,Andrew Page,Bishnu Pahari,Jeyaraj D Pandian,Andrea Panozo Rivero,Scott B. Patten,Neil Pearce,Rogelio Perez Padilla,Fernando Perez-Ruiz,Norberto Perico,Konrad Pesudovs,David Phillips,Michael R. Phillips,Kelsey Pierce,Sébastien D. S. Pion,Guilherme V. Polanczyk,Suzanne Polinder,C. Arden Pope,Svetlana Popova,Esteban Porrini,Farshad Pourmalek,Martin Prince,Rachel L. Pullan,Kapa D. Ramaiah,Dharani Ranganathan,Homie Razavi,Mathilda Regan,Jürgen Rehm,David B. Rein,G. Remuzzi,Kathryn Richardson,Frederick P. Rivara,Thomas Roberts,Carolyn Robinson,Felipe Rodriguez De Leòn,Luca Ronfani,Robin Room,Lisa C. Rosenfeld,Lesley Rushton,Ralph L. Sacco,Sukanta Saha,Uchechukwu Sampson,Lidia Sanchez-Riera,Ella Sanman,David C. Schwebel,James Scott,Maria Segui-Gomez,Saeid Shahraz,Donald S. Shepard,Hwashin Shin,Rupak Shivakoti,Donald H. Silberberg,David Singh,Gitanjali M Singh,Jasvinder A. Singh,Jessica Singleton,David A. Sleet,Karen Sliwa,Emma Smith,Jennifer L. Smith,Nicolas J. C. Stapelberg,Andrew C Steer,Timothy J. Steiner,Wilma A. Stolk,Lars Jacob Stovner,Christopher R. Sudfeld,Sana Syed,Giorgio Tamburlini,Mohammad Tavakkoli,Hugh R. Taylor,Jennifer A. Taylor,William J. Taylor,Bernadette Thomas,W. Murray Thomson,George D. Thurston,Imad M. Tleyjeh,Marcello Tonelli,Jeffrey A. Towbin,Thomas Truelsen,Miltiadis K. Tsilimbaris,Clotilde Ubeda,Eduardo A. Undurraga,Marieke J. van der Werf,Jim van Os,Monica S. Vavilala,Narayanaswamy Venketasubramanian,Mengru Wang,Wenzhi Wang,Kerrianne Watt,David Weatherall,Martin A. Weinstock,Robert G. Weintraub,Marc G. Weisskopf,Myrna M. Weissman,Richard A. White,Harvey Whiteford,Steven T. Wiersma,James D. Wilkinson,Hywel C Williams,Sean R.M. Williams,Emma Witt,Frederick Wolfe,Anthony D. Woolf,Sarah Wulf,Pon Hsiu Yeh,Anita K. M. Zaidi,Zhi Jie Zheng,David Zonies,Alan D. Lopez,Christopher J L Murray +363 more
A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010
Stephen S Lim,Theo Vos,Abraham D. Flaxman,Goodarz Danaei,Kenji Shibuya,Heather Adair-Rohani,Mohammad A. AlMazroa,Markus Amann,H. Ross Anderson,Kathryn G. Andrews,Martin J. Aryee,Charles Atkinson,Loraine J. Bacchus,Adil N. Bahalim,Kalpana Balakrishnan,John R. Balmes,Suzanne Barker-Collo,Amanda J Baxter,Michelle L. Bell,Jed D. Blore,Fiona M. Blyth,Carissa Bonner,Guilherme Borges,Rupert R A Bourne,Michel Boussinesq,Michael Brauer,Peter Brooks,Nigel Bruce,Bert Brunekreef,Claire Bryan-Hancock,Chiara Bucello,Rachelle Buchbinder,Fiona Bull,Richard T. Burnett,Tim Byers,Bianca Calabria,Jonathan R. Carapetis,Emily Carnahan,Zoë Chafe,Fiona J Charlson,Honglei Chen,Jian Shen Chen,Andrew T. A. Cheng,Jennifer C. Child,Aaron Cohen,K. Ellicott Colson,Benjamin C Cowie,Sarah C. Darby,Susan Darling,Adrian Davis,Louisa Degenhardt,Frank Dentener,Don C. Des Jarlais,Karen Devries,Mukesh Dherani,Eric L. Ding,E. Ray Dorsey,Tim Driscoll,Karen Edmond,S. Ali,Rebecca E. Engell,Patricia J. Erwin,Saman Fahimi,Gail Falder,Farshad Farzadfar,Alize J. Ferrari,Mariel M. Finucane,Seth Flaxman,F.G.R. Fowkes,Greg Freedman,Michael Freeman,Emmanuela Gakidou,Santu Ghosh,Edward Giovannucci,Gerhard Gmel,Kathryn Graham,Rebecca Grainger,Rebecca Grainger,Bridget F. Grant,David Gunnell,Hialy R. Gutierrez,Wayne Hall,Hans W. Hoek,Anthony Hogan,H. Dean Hosgood,Damian G Hoy,Howard Hu,Bryan Hubbell,Sally Hutchings,Sydney E. Ibeanusi,Gemma Jacklyn,Rashmi Jasrasaria,Jost B. Jonas,Haidong Kan,John A. Kanis,Nicholas J Kassebaum,Norito Kawakami,Young-Ho Khang,Shahab Khatibzadeh,Jon-Paul Khoo,Cindy Kok,Francine Laden,Ratilal Lalloo,Qing Lan,Tim Lathlean,Janet L Leasher,James Leigh,Yang Li,John K Lin,Steven E. Lipshultz,Stephanie J. London,Rafael Lozano,Yuan Lu,Joelle Mak,Reza Malekzadeh,Leslie Mallinger,Wagner Marcenes,Lyn March,Robin Marks,Randall V. Martin,Paul McGale,John J. McGrath,Sumi Mehta,Ziad A. Memish,George A. Mensah,Tony R. Merriman,Renata Micha,Renata Micha,Catherine Michaud,Vinod Mishra,Khayriyyah Mohd Hanafiah,Ali A. Mokdad,Lidia Morawska,Dariush Mozaffarian,Tasha B. Murphy,Mohsen Naghavi,Bruce Neal,Paul K. Nelson,Joan M. Nolla,Rosana E. Norman,Casey Olives,Saad B. Omer,Jessica Orchard,Richard H. Osborne,Bart Ostro,Andrew Page,Kiran Pandey,Charles D. H. Parry,Erin Passmore,Jayadeep Patra,Neil Pearce,Pamela M. Pelizzari,Max Petzold,Michael Phillips,Daniel Pope,C. Arden Pope,John Powles,Mayuree Rao,Homie Razavi,Eva Rehfuess,Jürgen Rehm,Beate Ritz,Frederick P. Rivara,Thomas Roberts,Carolyn Robinson,Jose Adolfo Rodriguez-Portales,Isabelle Romieu,Robin Room,Lisa C. Rosenfeld,Ananya Roy,Lesley Rushton,Joshua A. Salomon,Uchechukwu Sampson,Lidia Sanchez-Riera,Ella Sanman,Amir Sapkota,Soraya Seedat,Peilin Shi,Kevin D. Shield,Rupak Shivakoti,Gitanjali M Singh,David A. Sleet,Emma Smith,Kirk R. Smith,Nicolas J. C. Stapelberg,Kyle Steenland,Heidi Stöckl,Lars Jacob Stovner,Kurt Straif,Lahn Straney,George D. Thurston,Jimmy H. Tran,Rita Van Dingenen,Aaron van Donkelaar,J. Lennert Veerman,Lakshmi Vijayakumar,Robert G. Weintraub,Myrna M. Weissman,Richard A. White,Harvey Whiteford,Steven T. Wiersma,James D. Wilkinson,Hywel C Williams,Warwick Williams,Nick Wilson,Anthony D. Woolf,Paul S. F. Yip,Jan M Zielinski,Alan D. Lopez,Christopher J L Murray,Majid Ezzati +210 more