Impaired innate interferon induction in severe therapy resistant atopic asthmatic children.
Michael R. Edwards,Nicolas Regamey,Marjolaine Vareille,Elisabeth Kieninger,Atul Gupta,Amelia Shoemark,Sejal Saglani,A Sykes,J Macintyre,Jane C. Davies,C Bossley,Andrew Bush,Sebastian L. Johnston +12 more
TLDR
It is shown that compared with non-allergic healthy control children, bronchial epithelial cells cultured ex vivo from severe therapy resistant atopic asthmatic children have profoundly impaired interferon-β and interferons-λ mRNA and protein in response to rhinovirus (RV) and polyIC stimulation, and this is a feature of STRA.About:
This article is published in Mucosal Immunology.The article was published on 2013-07-01 and is currently open access. It has received 189 citations till now. The article focuses on the topics: Interferon.read more
Citations
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Journal ArticleDOI
The immunology of asthma
Bart N. Lambrecht,Hamida Hammad +1 more
TL;DR: Results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans are discussed and the extraordinary heterogeneity of asthma is described.
Journal ArticleDOI
The Cytokines of Asthma
TL;DR: The cytokine networks driving asthma are reviewed, placing these in cellular context and incorporating insights from cytokine-targeting therapies in the clinic, to argue that the development of new and improved therapeutics will require understanding the diverse mechanisms underlying the spectrum of asthma pathologies.
Journal ArticleDOI
Epidemiology of Asthma in Children and Adults.
TL;DR: There is an urgent need to further investigate the interrelationship between environmental and genetic determinants to identify high risk groups and key modifiable exposures and to define the role of environmental exposures in the development of asthma in both children and adults.
Journal ArticleDOI
Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells
Claudia U. Duerr,Connor D A McCarthy,Barbara C. Mindt,Manuel Rubio,Alexandre P. Meli,Julien Pothlichet,Megan M. Eva,Jean-François Gauchat,Salman T. Qureshi,Bruce Mazer,Karen L. Mossman,Danielle Malo,Ana M. Gamero,Silvia M. Vidal,Irah L. King,Marika Sarfati,Jörg H. Fritz +16 more
TL;DR: It is found that deficiency in signaling via type I interferon receptor led to deregulated activation of group 2 innate lymphoid cells (ILC2 cells) and infection-associated type 2 immunopathology.
Journal ArticleDOI
Early local immune defences in the respiratory tract
TL;DR: The cell types that coordinate pathogen clearance and tissue repair through the serial secretion of cytokines are described, and how the environment and comorbidity influence this response is discussed.
References
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Journal ArticleDOI
Corrigendum: A diverse range of gene products are effectors of the type I interferon antiviral response.
John W. Schoggins,Sam J. Wilson,Maryline Panis,Mary Murphy,Christopher T. Jones,Paul D. Bieniasz,Charles M. Rice +6 more
TL;DR: In this paper, the authors used the WNV-GFP stock used in the data set (Fig. 2 and Supplementary Table 8 of the original Letter) for West Nile virus (WNV) in this Letter was actually Venezuelan equine encephalitis virus (VEEV)-GFP.
Journal ArticleDOI
Early intervention with budesonide in mild persistent asthma: a randomised, double-blind trial
TL;DR: Long-term, once-daily treatment with low-dose budesonide decreases the risk of severe exacerbations and improves asthma control in patients with mild persistent asthma of recent onset.
Journal ArticleDOI
Frequency, severity, and duration of rhinovirus infections in asthmatic and non-asthmatic individuals: a longitudinal cohort study
Jonathan M Corne,Clare Marshall,Sandra Smith,Jacquie Schreiber,G. Sanderson,Stephen T. Holgate,Sebastian L. Johnston +6 more
TL;DR: People with atopic asthma are not at greater risk of rhinovirus infection than healthy individuals but suffer from more frequent LRT infections and have more severe and longer-lasting LRT symptoms.
Journal ArticleDOI
Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production.
Simon D. Message,Vasile Laza-Stanca,Patrick Mallia,Hayley L. Parker,Jie Zhu,Tatiana Kebadze,Marco Contoli,Gwen Sanderson,Onn Min Kon,Alberto Papi,Peter K. Jeffery,Luminita A. Stanciu,Sebastian L. Johnston +12 more
TL;DR: Increased RV-induced clinical illness severity in asthmatic compared with normal subjects is demonstrated, evidence of strong relationships between virus load, lower airway virus-induced inflammation and asthma exacerbation severity is provided, and indicates augmented Th2 or impaired Th1 or IL-10 immunity are likely important mechanisms.
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