Impaired innate interferon induction in severe therapy resistant atopic asthmatic children.
Michael R. Edwards,Nicolas Regamey,Marjolaine Vareille,Elisabeth Kieninger,Atul Gupta,Amelia Shoemark,Sejal Saglani,A Sykes,J Macintyre,Jane C. Davies,C Bossley,Andrew Bush,Sebastian L. Johnston +12 more
TLDR
It is shown that compared with non-allergic healthy control children, bronchial epithelial cells cultured ex vivo from severe therapy resistant atopic asthmatic children have profoundly impaired interferon-β and interferons-λ mRNA and protein in response to rhinovirus (RV) and polyIC stimulation, and this is a feature of STRA.About:
This article is published in Mucosal Immunology.The article was published on 2013-07-01 and is currently open access. It has received 189 citations till now. The article focuses on the topics: Interferon.read more
Citations
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Journal ArticleDOI
The immunology of asthma
Bart N. Lambrecht,Hamida Hammad +1 more
TL;DR: Results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans are discussed and the extraordinary heterogeneity of asthma is described.
Journal ArticleDOI
The Cytokines of Asthma
TL;DR: The cytokine networks driving asthma are reviewed, placing these in cellular context and incorporating insights from cytokine-targeting therapies in the clinic, to argue that the development of new and improved therapeutics will require understanding the diverse mechanisms underlying the spectrum of asthma pathologies.
Journal ArticleDOI
Epidemiology of Asthma in Children and Adults.
TL;DR: There is an urgent need to further investigate the interrelationship between environmental and genetic determinants to identify high risk groups and key modifiable exposures and to define the role of environmental exposures in the development of asthma in both children and adults.
Journal ArticleDOI
Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells
Claudia U. Duerr,Connor D A McCarthy,Barbara C. Mindt,Manuel Rubio,Alexandre P. Meli,Julien Pothlichet,Megan M. Eva,Jean-François Gauchat,Salman T. Qureshi,Bruce Mazer,Karen L. Mossman,Danielle Malo,Ana M. Gamero,Silvia M. Vidal,Irah L. King,Marika Sarfati,Jörg H. Fritz +16 more
TL;DR: It is found that deficiency in signaling via type I interferon receptor led to deregulated activation of group 2 innate lymphoid cells (ILC2 cells) and infection-associated type 2 immunopathology.
Journal ArticleDOI
Early local immune defences in the respiratory tract
TL;DR: The cell types that coordinate pathogen clearance and tissue repair through the serial secretion of cytokines are described, and how the environment and comorbidity influence this response is discussed.
References
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Journal ArticleDOI
Asthma and natural colds. Inflammatory indices in induced sputum: a feasibility study.
Marcia Margaret Menezes Pizzichini,Emilio Pizzichini,Ann Efthimiadis,Anoop Chauhan,Sebastian L. Johnston,Pat Hussack,James B. Mahony,Jerry Dolovich,Frederick E. Hargreave +8 more
TL;DR: It is concluded that induced sputum examination can be used to study the effects of natural colds and influenza on the airways of the lungs and the results suggest that naturalcolds, on Day 4, cause neutrophilic lower airway inflammation that is greater in asthmatics than in healthy subjects.
Journal ArticleDOI
Respiratory virus induction of alpha-, beta- and lambda-interferons in bronchial epithelial cells and peripheral blood mononuclear cells.
Musa Khaitov,Vasile Laza-Stanca,Michael R. Edwards,Ross P. Walton,Gernot Rohde,Gernot Rohde,Marco Contoli,Marco Contoli,Alberto Papi,Luminita A. Stanciu,Sergei V. Kotenko,Sergei V. Kotenko,Sebastian L. Johnston +12 more
TL;DR: Replacement of deficient interferon is a candidate new therapy for asthma exacerbations and their relative capacities for α, β, and λ‐interferon production are unknown.
Journal ArticleDOI
Management of severe asthma in children.
Andrew Bush,Sejal Saglani +1 more
TL;DR: Getting the basics right in children with apparently severe asthma will remain the foundation of management for the foreseeable future.
Journal ArticleDOI
The importance of nurse led home visits in the assessment of children with problematic asthma
M Bracken,Louise Fleming,Pippa Hall,N Van Stiphout,C Bossley,E Biggart,Nicola Wilson,Andrew Bush +7 more
TL;DR: Nurse-led assessments including a home visit can help identify potentially modifiable factors for poorly controlled symptoms in children with problematic asthma.
Journal ArticleDOI
In vitro susceptibility to rhinovirus infection is greater for bronchial than for nasal airway epithelial cells in human subjects.
Nilceia Lopez-Souza,Silvio Favoreto,Hofer Wong,Theresa Ward,Shigeo Yagi,David P. Schnurr,Walter E. Finkbeiner,Gregory Dolganov,Jonathan Widdicombe,Homer A. Boushey,Pedro C. Avila +10 more
TL;DR: Differentiated nasal epithelial cells might have mechanisms of increased resistance to rhinovirus infection compared with bronchial epithelium, and previous reports of increased susceptibility to HRV infection in epithel cells from asthmatic subjects were not confirmed.
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