Impaired innate interferon induction in severe therapy resistant atopic asthmatic children.
Michael R. Edwards,Nicolas Regamey,Marjolaine Vareille,Elisabeth Kieninger,Atul Gupta,Amelia Shoemark,Sejal Saglani,A Sykes,J Macintyre,Jane C. Davies,C Bossley,Andrew Bush,Sebastian L. Johnston +12 more
TLDR
It is shown that compared with non-allergic healthy control children, bronchial epithelial cells cultured ex vivo from severe therapy resistant atopic asthmatic children have profoundly impaired interferon-β and interferons-λ mRNA and protein in response to rhinovirus (RV) and polyIC stimulation, and this is a feature of STRA.About:
This article is published in Mucosal Immunology.The article was published on 2013-07-01 and is currently open access. It has received 189 citations till now. The article focuses on the topics: Interferon.read more
Citations
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Journal ArticleDOI
Rhinovirus inhibits IL-17A and the downstream immune responses in allergic asthma.
Anna Graser,Arif B. Ekici,Nina Sopel,Volker O. Melichar,Theodor Zimmermann,Nikolaos G. Papadopoulos,Styliani Taka,Fulvia Ferrazzi,Tytti Vuorinen,Susetta Finotto +9 more
TL;DR: It is found that asthmatic children with a RV infection in their upper airways have upregulated mRNA levels of the antiviral cytokine interferon type I (IFN)-β and the transcription factor T-box 21 (TBX21) and reduced levels of IL-17A protein in their peripheral blood mononuclear cells (PBMCs).
Journal ArticleDOI
Childhood asthma heterogeneity at the era of precision medicine: Modulating the immune response or the microbiota for the management of asthma attack
Stéphanie Lejeune,Antoine Deschildre,Olivier Le Rouzic,Ilka Engelmann,Rodrigue Dessein,Muriel Pichavant,Philippe Gosset +6 more
TL;DR: A better definition of asthma endotypes associated with precision medicine might lead to substantial progress in the management of severe childhood asthma, and improving the knowledge of the pathophysiological processes induced by infections has led to new opportunities for the development of preventive or curative therapeutics for acute asthma.
Journal ArticleDOI
Mast cells are permissive for rhinovirus replication: potential implications for asthma exacerbations
TL;DR: Mast cells play a key role in asthma where their numbers are increased in the bronchial epithelium with increasing disease severity, andHRVs are a major trigger of asthma exacerbations.
Journal ArticleDOI
Cytokines and Chemokines as Biomarkers of Future Asthma.
TL;DR: The evidence is that the earliest cytokine and chemokine signals will come from the study of bronchial epithelial cell function and their interactions with viruses and the microbiome, which critically impacts the development of Type 2 inflammatory responses.
Journal ArticleDOI
Primary airway epithelial cell culture and asthma in children-lessons learnt and yet to come.
TL;DR: There are consistent differences between children with and without asthma for nasal and bronchial AEC mediator release following exposure to a range of pro‐inflammatory stimulants including interleukins (IL)‐1β, IL‐4, and IL‐13.
References
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A diverse range of gene products are effectors of the type I interferon antiviral response
John W. Schoggins,Sam J. Wilson,Maryline Panis,Mary Murphy,Christopher T. Jones,Paul D. Bieniasz,Charles M. Rice +6 more
TL;DR: It is shown that different viruses are targeted by unique sets of ISGs, and that each viral species is susceptible to multiple antiviral genes, which together encompass a range of inhibitory activities.
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Community study of role of viral infections in exacerbations of asthma in 9-11 year old children.
Sebastian L. Johnston,Philip Pattemore,G. Sanderson,Sandra Smith,F Lampe,Lynn Josephs,P. Symington,S. O'Toole,S. H. Myint,D. A. J. Tyrrell +9 more
TL;DR: This study supports the hypothesis that upper respiratory viral infections are associated with 80-85% of asthma exacerbations in school age children.
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A large-scale, consortium-based genomewide association study of asthma.
Miriam F. Moffatt,Ivo Gut,Florence Demenais,David P. Strachan,Emmanuelle Bouzigon,Simon Heath,Erika von Mutius,Martin Farrall,Mark Lathrop,William O.C.M. Cookson +9 more
TL;DR: A few common alleles are associated with disease risk at all ages and suggest a role for communication of epithelial damage to the adaptive immune system and activation of airway inflammation in asthma.
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IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex.
Sergei V. Kotenko,Grant Gallagher,Vitaliy V. Baurin,Anita Lewis-Antes,Meiling Shen,Nital K. Shah,Jerome A. Langer,Faruk Sheikh,Harold Dickensheets,Raymond P. Donnelly +9 more
TL;DR: The identification of a ligand-receptor system that, upon engagement, leads to the establishment of an antiviral state and may contribute to antiviral or other defenses by a mechanism similar to, but independent of, type I IFNs.
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Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group
Romain Pauwels,Claes-Göran Löfdahl,Dirkje S. Postma,Anne E. Tattersfield,Paul M. O'Byrne,Peter J. Barnes,A Ullman +6 more
TL;DR: In patients who have persistent symptoms of asthma despite treatment with inhaled glucocorticoids, the addition of formoterol to budesonid therapy or the use of a higher dose of budesonide may be beneficial.
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