Impaired innate interferon induction in severe therapy resistant atopic asthmatic children.
Michael R. Edwards,Nicolas Regamey,Marjolaine Vareille,Elisabeth Kieninger,Atul Gupta,Amelia Shoemark,Sejal Saglani,A Sykes,J Macintyre,Jane C. Davies,C Bossley,Andrew Bush,Sebastian L. Johnston +12 more
TLDR
It is shown that compared with non-allergic healthy control children, bronchial epithelial cells cultured ex vivo from severe therapy resistant atopic asthmatic children have profoundly impaired interferon-β and interferons-λ mRNA and protein in response to rhinovirus (RV) and polyIC stimulation, and this is a feature of STRA.About:
This article is published in Mucosal Immunology.The article was published on 2013-07-01 and is currently open access. It has received 189 citations till now. The article focuses on the topics: Interferon.read more
Citations
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Journal ArticleDOI
The immunology of asthma
Bart N. Lambrecht,Hamida Hammad +1 more
TL;DR: Results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans are discussed and the extraordinary heterogeneity of asthma is described.
Journal ArticleDOI
The Cytokines of Asthma
TL;DR: The cytokine networks driving asthma are reviewed, placing these in cellular context and incorporating insights from cytokine-targeting therapies in the clinic, to argue that the development of new and improved therapeutics will require understanding the diverse mechanisms underlying the spectrum of asthma pathologies.
Journal ArticleDOI
Epidemiology of Asthma in Children and Adults.
TL;DR: There is an urgent need to further investigate the interrelationship between environmental and genetic determinants to identify high risk groups and key modifiable exposures and to define the role of environmental exposures in the development of asthma in both children and adults.
Journal ArticleDOI
Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells
Claudia U. Duerr,Connor D A McCarthy,Barbara C. Mindt,Manuel Rubio,Alexandre P. Meli,Julien Pothlichet,Megan M. Eva,Jean-François Gauchat,Salman T. Qureshi,Bruce Mazer,Karen L. Mossman,Danielle Malo,Ana M. Gamero,Silvia M. Vidal,Irah L. King,Marika Sarfati,Jörg H. Fritz +16 more
TL;DR: It is found that deficiency in signaling via type I interferon receptor led to deregulated activation of group 2 innate lymphoid cells (ILC2 cells) and infection-associated type 2 immunopathology.
Journal ArticleDOI
Early local immune defences in the respiratory tract
TL;DR: The cell types that coordinate pathogen clearance and tissue repair through the serial secretion of cytokines are described, and how the environment and comorbidity influence this response is discussed.
References
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Journal ArticleDOI
Rhinovirus induces MUC5AC in a human infection model and in vitro via NF-κB and EGFR pathways.
Christopher A. Hewson,JJ Haas,Nathan W. Bartlett,Simon D. Message,Vasile Laza-Stanca,Tatiana Kebadze,Gaetano Caramori,Jie Zhu,M.R. Edbrooke,Luminita A. Stanciu,Onn Min Kon,Alberto Papi,Peter K. Jeffery,Michael R. Edwards,Sebastian L. Johnston +14 more
TL;DR: Investigating RV induction of MUC5AC in vivo and in vitro identifies targets for development of pharmacologic intervention to treat mucus hypersecretion in RV-induced illness and reveals the complex serial signalling cascade involved.
Journal ArticleDOI
Exogenous IFN-β has antiviral and anti-inflammatory properties in primary bronchial epithelial cells from asthmatic subjects exposed to rhinovirus
Julie A. Cakebread,Yunhe Xu,Christopher Grainge,Valia Kehagia,Peter H. Howarth,Stephen T. Holgate,Donna E. Davies +6 more
TL;DR: In this paper, the potential of IFN-β to modulate antiviral and proinflammatory responses in primary bronchial epithelial cells (PBECs) from non-asthmatic and asthmatic subjects was investigated.
Journal ArticleDOI
Impaired virus-induced interferon-α2 release in adult asthmatic patients
TL;DR: It is demonstrated that children with allergic asthma produced significantly lower amounts of virus‐induced IFN‐α2 compared with healthy children or those with intrinsic asthma.
Journal ArticleDOI
Atopic Phenotype in Children Is Associated with Decreased Virus-Induced Interferon-α Release
TL;DR: The IFN-α level may serve as an additional in vitro marker for the definition of atopy in children after further prospective evaluation, as an early atopic phenotype was related to a reduction in virus induced IFn-α release from blood cultures.
Journal ArticleDOI
The Role of IL-15 Deficiency in the Pathogenesis of Virus-Induced Asthma Exacerbations
Vasile Laza-Stanca,Simon D. Message,Simon D. Message,Michael R. Edwards,Hayley L. Parker,Mihnea Zdrenghea,Tatiana Kebadze,Onn Min Kon,Patrick Mallia,Patrick Mallia,Luminita A. Stanciu,Sebastian L. Johnston,Sebastian L. Johnston +12 more
TL;DR: IL-15 levels in BAL fluid were decreased in asthmatics and inversely related with airway hyperresponsiveness and with virus load during in vivo rhinovirus infection, suggesting deficient IL-15 production in asthma may be important in the pathogenesis of asthma exacerbations.
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