Impaired innate interferon induction in severe therapy resistant atopic asthmatic children.
Michael R. Edwards,Nicolas Regamey,Marjolaine Vareille,Elisabeth Kieninger,Atul Gupta,Amelia Shoemark,Sejal Saglani,A Sykes,J Macintyre,Jane C. Davies,C Bossley,Andrew Bush,Sebastian L. Johnston +12 more
TLDR
It is shown that compared with non-allergic healthy control children, bronchial epithelial cells cultured ex vivo from severe therapy resistant atopic asthmatic children have profoundly impaired interferon-β and interferons-λ mRNA and protein in response to rhinovirus (RV) and polyIC stimulation, and this is a feature of STRA.About:
This article is published in Mucosal Immunology.The article was published on 2013-07-01 and is currently open access. It has received 189 citations till now. The article focuses on the topics: Interferon.read more
Citations
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Assessing the association of early life antibiotic prescription with asthma exacerbations, impaired antiviral immunity, and genetic variants in 17q21: a population-based birth cohort study.
Aida Semic-Jusufagic,Danielle Belgrave,Andrew Pickles,Aurica G. Telcian,Eteri Bakhsoliani,Annemarie Sykes,Angela Simpson,Sebastian L. Johnston,Adnan Custovic +8 more
TL;DR: Hidden factors that may increase the likelihood of both early life antibiotic prescription and later asthma are an increased susceptibility to viral infections consequent upon impaired antiviral immunity and genetic variants on 17q21.
Journal ArticleDOI
Higher airborne pollen concentrations correlated with increased SARS-CoV-2 infection rates, as evidenced from 31 countries across the globe.
Athanasios Damialis,Stefanie Gilles,Mikhail Sofiev,Viktoria Sofieva,Franziska Kolek,Daniela Bayr,Maria Pilar Plaza,Vivien Leier-Wirtz,Sigrid Kaschuba,Lewis H. Ziska,Leonard Bielory,László Makra,María del Mar Trigo,Covid,Claudia Traidl-Hoffmann +14 more
TL;DR: In this article, the authors investigated whether the same applies to the pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is sensitive to antiviral interferons, if infection waves coincide with high airborne pollen concentrations.
Journal ArticleDOI
Increased nuclear suppressor of cytokine signaling 1 in asthmatic bronchial epithelium suppresses rhinovirus induction of innate interferons.
V Gielen,Annemarie Sykes,Jie Zhu,Brian H. K. Chan,Jonathan Macintyre,Nicolas Regamey,Elisabeth Kieninger,Atul Gupta,Amelia Shoemark,Cara Bossley,Jane C. Davies,Sejal Saglani,Patrick Walker,Sandra E. Nicholson,Sandra E. Nicholson,Alexander H. Dalpke,Onn Min Kon,Andrew Bush,Sebastian L. Johnston,Michael R. Edwards,Michael R. Edwards +20 more
TL;DR: In this paper, the expression of suppressor of cytokine signaling (SOCS) 1 in tissues from asthmatic patients and its possible role in impaired virus-induced interferon induction in these patients are investigated.
Journal ArticleDOI
Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing
Danielle Belgrave,Angela Simpson,Aida Semic-Jusufagic,Clare S. Murray,Iain Buchan,Andrew Pickles,Adnan Custovic +6 more
TL;DR: A novel group of children with persistent troublesome wheeze, who have markedly different outcomes compared with persistent wheezers with controlled disease, is identified.
Journal ArticleDOI
Azithromycin induces anti-viral effects in cultured bronchial epithelial cells from COPD patients
TL;DR: Azithromycin transiently increased expression of IFNβ and IFNλ1 and RIG-I like helicases in un-infected COPD cells and increased rhinovirus-induced expression of interferons in COPD but not in healthy bronchial epithelium, supporting azithromyzin’s emerging role in prevention of exacerbations of COPD.
References
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A diverse range of gene products are effectors of the type I interferon antiviral response
John W. Schoggins,Sam J. Wilson,Maryline Panis,Mary Murphy,Christopher T. Jones,Paul D. Bieniasz,Charles M. Rice +6 more
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Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group
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TL;DR: In patients who have persistent symptoms of asthma despite treatment with inhaled glucocorticoids, the addition of formoterol to budesonid therapy or the use of a higher dose of budesonide may be beneficial.
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