Impaired innate interferon induction in severe therapy resistant atopic asthmatic children.
Michael R. Edwards,Nicolas Regamey,Marjolaine Vareille,Elisabeth Kieninger,Atul Gupta,Amelia Shoemark,Sejal Saglani,A Sykes,J Macintyre,Jane C. Davies,C Bossley,Andrew Bush,Sebastian L. Johnston +12 more
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TLDR
It is shown that compared with non-allergic healthy control children, bronchial epithelial cells cultured ex vivo from severe therapy resistant atopic asthmatic children have profoundly impaired interferon-β and interferons-λ mRNA and protein in response to rhinovirus (RV) and polyIC stimulation, and this is a feature of STRA.About:
This article is published in Mucosal Immunology.The article was published on 2013-07-01 and is currently open access. It has received 189 citations till now. The article focuses on the topics: Interferon.read more
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Airway epithelial response to RSV is impaired in multiciliated and goblet cells in asthma
Aurore C. A. Gay,Martin Banchero,Orestes A Carpaij,T. M. Tessa Marthe Kole,Leonie Apperloo,Djoke van Gosliga,Putri Ayu Fajar,Gerard H. Koppelman,Louis Bont,Rudi W. Hendriks,Maarten van den Berge,Martijn C. Nawijn +11 more
TL;DR: In this paper , the authors investigated the transcriptional response to RSV infection of primary bronchial epithelial cells (pBECs) from both asthma patients and healthy donors, at a single-cell resolution.
Journal ArticleDOI
Reactive Oxygen Species, Interferon and Antiviral Innate Immune Response in Nasal Mucosa
Seung No Hong,Hyun Jik Kim +1 more
TL;DR: It is estimated that ROS are necessary for the innate immune response and trigger the induction of IFN-related innate immuneresponse to resist respiratory virus infection in human respiratory mucosa.
Journal ArticleDOI
Związek między infekcjami wirusowymi we wczesnym okresie życia a późniejszym rozwojem astmy jest niezależny od rodzaju wirusa
TL;DR: W nieskorygowanych analizach wszystkie wirusy i patogenne bakterie wykryte w czasie epizodow objawow z drog oddechowych wiązaly sie ze zwiekszonym ryzykiem rozwoju astmy w poźniejszym dziecinstwie.
Journal ArticleDOI
Interferons as negative regulators of ILC2s in allergic lung inflammation and respiratory viral infections.
Book ChapterDOI
Cellular and Molecular Basis of Asthma
TL;DR: There is detailed explanation of the role played by various cytokines and chemokines in this process followed by inflammatory process resulting in airway remodeling and the future therapeutic options to treat atopic asthma are explored.
References
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A diverse range of gene products are effectors of the type I interferon antiviral response
John W. Schoggins,Sam J. Wilson,Maryline Panis,Mary Murphy,Christopher T. Jones,Paul D. Bieniasz,Charles M. Rice +6 more
TL;DR: It is shown that different viruses are targeted by unique sets of ISGs, and that each viral species is susceptible to multiple antiviral genes, which together encompass a range of inhibitory activities.
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Community study of role of viral infections in exacerbations of asthma in 9-11 year old children.
Sebastian L. Johnston,Philip Pattemore,G. Sanderson,Sandra Smith,F Lampe,Lynn Josephs,P. Symington,S. O'Toole,S. H. Myint,D. A. J. Tyrrell +9 more
TL;DR: This study supports the hypothesis that upper respiratory viral infections are associated with 80-85% of asthma exacerbations in school age children.
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A large-scale, consortium-based genomewide association study of asthma.
Miriam F. Moffatt,Ivo Gut,Florence Demenais,David P. Strachan,Emmanuelle Bouzigon,Simon Heath,Erika von Mutius,Martin Farrall,Mark Lathrop,William O.C.M. Cookson +9 more
TL;DR: A few common alleles are associated with disease risk at all ages and suggest a role for communication of epithelial damage to the adaptive immune system and activation of airway inflammation in asthma.
Journal ArticleDOI
IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex.
Sergei V. Kotenko,Grant Gallagher,Vitaliy V. Baurin,Anita Lewis-Antes,Meiling Shen,Nital K. Shah,Jerome A. Langer,Faruk Sheikh,Harold Dickensheets,Raymond P. Donnelly +9 more
TL;DR: The identification of a ligand-receptor system that, upon engagement, leads to the establishment of an antiviral state and may contribute to antiviral or other defenses by a mechanism similar to, but independent of, type I IFNs.
Journal ArticleDOI
Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group
Romain Pauwels,Claes-Göran Löfdahl,Dirkje S. Postma,Anne E. Tattersfield,Paul M. O'Byrne,Peter J. Barnes,A Ullman +6 more
TL;DR: In patients who have persistent symptoms of asthma despite treatment with inhaled glucocorticoids, the addition of formoterol to budesonid therapy or the use of a higher dose of budesonide may be beneficial.
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