Impaired innate interferon induction in severe therapy resistant atopic asthmatic children.
Michael R. Edwards,Nicolas Regamey,Marjolaine Vareille,Elisabeth Kieninger,Atul Gupta,Amelia Shoemark,Sejal Saglani,A Sykes,J Macintyre,Jane C. Davies,C Bossley,Andrew Bush,Sebastian L. Johnston +12 more
TLDR
It is shown that compared with non-allergic healthy control children, bronchial epithelial cells cultured ex vivo from severe therapy resistant atopic asthmatic children have profoundly impaired interferon-β and interferons-λ mRNA and protein in response to rhinovirus (RV) and polyIC stimulation, and this is a feature of STRA.About:
This article is published in Mucosal Immunology.The article was published on 2013-07-01 and is currently open access. It has received 189 citations till now. The article focuses on the topics: Interferon.read more
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The immunology of asthma
Bart N. Lambrecht,Hamida Hammad +1 more
TL;DR: Results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans are discussed and the extraordinary heterogeneity of asthma is described.
Journal ArticleDOI
The Cytokines of Asthma
TL;DR: The cytokine networks driving asthma are reviewed, placing these in cellular context and incorporating insights from cytokine-targeting therapies in the clinic, to argue that the development of new and improved therapeutics will require understanding the diverse mechanisms underlying the spectrum of asthma pathologies.
Journal ArticleDOI
Epidemiology of Asthma in Children and Adults.
TL;DR: There is an urgent need to further investigate the interrelationship between environmental and genetic determinants to identify high risk groups and key modifiable exposures and to define the role of environmental exposures in the development of asthma in both children and adults.
Journal ArticleDOI
Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells
Claudia U. Duerr,Connor D A McCarthy,Barbara C. Mindt,Manuel Rubio,Alexandre P. Meli,Julien Pothlichet,Megan M. Eva,Jean-François Gauchat,Salman T. Qureshi,Bruce Mazer,Karen L. Mossman,Danielle Malo,Ana M. Gamero,Silvia M. Vidal,Irah L. King,Marika Sarfati,Jörg H. Fritz +16 more
TL;DR: It is found that deficiency in signaling via type I interferon receptor led to deregulated activation of group 2 innate lymphoid cells (ILC2 cells) and infection-associated type 2 immunopathology.
Journal ArticleDOI
Early local immune defences in the respiratory tract
TL;DR: The cell types that coordinate pathogen clearance and tissue repair through the serial secretion of cytokines are described, and how the environment and comorbidity influence this response is discussed.
References
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Miriam F. Moffatt,Michael Kabesch,Liming Liang,Anna L. Dixon,David P. Strachan,Simon Heath,Martin Depner,Andrea von Berg,Albrecht Bufe,Ernst Rietschel,Andrea Heinzmann,Burkard Simma,Thomas Frischer,Saffron A.G. Willis-Owen,Kenny C. C. Wong,Thomas Illig,Christian Vogelberg,Stephan K. Weiland,Erika von Mutius,Gonçalo R. Abecasis,Martin Farrall,Ivo Gut,G. Mark Lathrop,William O.C.M. Cookson +23 more
TL;DR: The results indicate that genetic variants regulating ORMDL3 expression are determinants of susceptibility to childhood asthma.
Supplementary materials to a paper "A large-scale, consortium-based genomewide association study of asthma"
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TYPE I INTERFERONS (α/β) IN IMMUNITY AND AUTOIMMUNITY
TL;DR: The significance of type I interferons (IFN-α/β) in biology and medicine renders research on their activities continuously relevant to our understanding of normal and abnormal (auto) immune responses as mentioned in this paper.
Journal ArticleDOI
Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus
Peter A. B. Wark,Sebastian L. Johnston,Fabio Bucchieri,Robert M. Powell,Sarah M. Puddicombe,Vasile Laza-Stanca,Stephen T. Holgate,Donna E. Davies +7 more
TL;DR: A causal link between deficient interferon-β, impaired apoptosis and increased virus replication is demonstrated, suggesting a novel use for type I interferons in the treatment or prevention of virus-induced asthma exacerbations.
Journal ArticleDOI
Role of deficient type III interferon-λ production in asthma exacerbations
Marco Contoli,Simon D. Message,Vasile Laza-Stanca,Michael R. Edwards,Peter A. B. Wark,Peter A. B. Wark,Nathan W. Bartlett,Tatiana Kebadze,Patrick Mallia,Luminita A. Stanciu,Hayley L. Parker,Louise Slater,Anita Lewis-Antes,Onn Min Kon,Stephen T. Holgate,Donna E. Davies,Sergei V. Kotenko,Alberto Papi,Sebastian L. Johnston +18 more
TL;DR: In this paper, the authors show deficient induction of interferon-λs by rhinovirus in primary bronchial epithelial cells and alveolar macrophages, which was highly correlated with severity of rhinovirus induced asthma exacerbation and virus load in experimentally infected human volunteers.
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