Impaired innate interferon induction in severe therapy resistant atopic asthmatic children.
Michael R. Edwards,Nicolas Regamey,Marjolaine Vareille,Elisabeth Kieninger,Atul Gupta,Amelia Shoemark,Sejal Saglani,A Sykes,J Macintyre,Jane C. Davies,C Bossley,Andrew Bush,Sebastian L. Johnston +12 more
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TLDR
It is shown that compared with non-allergic healthy control children, bronchial epithelial cells cultured ex vivo from severe therapy resistant atopic asthmatic children have profoundly impaired interferon-β and interferons-λ mRNA and protein in response to rhinovirus (RV) and polyIC stimulation, and this is a feature of STRA.About:
This article is published in Mucosal Immunology.The article was published on 2013-07-01 and is currently open access. It has received 189 citations till now. The article focuses on the topics: Interferon.read more
Citations
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Glucocorticosteroids enhance replication of respiratory viruses: effect of adjuvant interferon.
Belinda J. Thomas,Belinda J. Thomas,Rebecca A. Porritt,Paul J. Hertzog,Philip G. Bardin,Philip G. Bardin,Michelle D. Tate +6 more
TL;DR: It is demonstrated that GCS cause an extrinsic compromise in anti-viral defences, enhancing respiratory virus infections and provides a rationale for adjuvant IFN treatment.
Journal ArticleDOI
The Role of Viral Infection in Pulmonary Exacerbations of Bronchiectasis in Adults: A Prospective Study
Yong-hua Gao,Wei Jie Guan,Gang Xu,Zhi Ya Lin,Yan Tang,Zhi Min Lin,Yang Gao,Hui Min Li,Nan-Shan Zhong,Guojun Zhang,Rongchang Chen +10 more
TL;DR: Prevalence of viral infections, detected by polymerase chain reaction assay, is higher in cases of bronchiectasis exacerbations than in steady-state bronchiECTasis, suggesting that respiratory viruses play crucial roles in triggering bronchiectomy exacerbations.
Journal ArticleDOI
Postnatal Innate Immune Development: From Birth to Adulthood.
TL;DR: The state-of-the-art on normal postnatal innate immune ontogeny is described and research areas that are currently explored or should be further addressed are highlighted.
Journal ArticleDOI
A Comprehensive Evaluation of Nasal and Bronchial Cytokines and Chemokines Following Experimental Rhinovirus Infection in Allergic Asthma: Increased Interferons (IFN-γ and IFN-λ) and Type 2 Inflammation (IL-5 and IL-13).
Trevor T. Hansel,Tanushree Tunstall,Maria-Belen Trujillo-Torralbo,Maria-Belen Trujillo-Torralbo,Betty Shamji,Ajerico del-Rosario,Ajerico del-Rosario,Jaideep Dhariwal,Jaideep Dhariwal,Paul D. W. Kirk,Michael P. H. Stumpf,Jens Koopmann,Jens Koopmann,Aurica G. Telcian,Julia Aniscenko,Leila Gogsadze,Eteri Bakhsoliani,Luminita A. Stanciu,Nathan W. Bartlett,Michael R. Edwards,Ross P. Walton,Patrick Mallia,Patrick Mallia,Toby Hunt,Trevor Hunt,Duncan Hunt,John Westwick,Matthew J. Edwards,Onn Min Kon,David A. Jackson,Sebastian L. Johnston,Sebastian L. Johnston +31 more
TL;DR: Precision sampling of mucosal lining fluid identifies robust interferon and type 2 responses in the upper and lower airways of asthmatics during an asthma exacerbation.
Journal ArticleDOI
Allergy in severe asthma
S. Del Giacco,Arzu Bakirtas,E.H.D. Bel,Adnan Custovic,Zuzana Diamant,Zuzana Diamant,Eckard Hamelmann,Enrico Heffler,O. Kalayci,Sejal Saglani,Svetlana Sergejeva,Sven Seys,Angela Simpson,Leif Bjermer +13 more
TL;DR: The ‘Allergy and Asthma Severity’ EAACI Task Force examined the current evidence and produced this position document on the role of allergy in severe asthma.
References
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A diverse range of gene products are effectors of the type I interferon antiviral response
John W. Schoggins,Sam J. Wilson,Maryline Panis,Mary Murphy,Christopher T. Jones,Paul D. Bieniasz,Charles M. Rice +6 more
TL;DR: It is shown that different viruses are targeted by unique sets of ISGs, and that each viral species is susceptible to multiple antiviral genes, which together encompass a range of inhibitory activities.
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Miriam F. Moffatt,Ivo Gut,Florence Demenais,David P. Strachan,Emmanuelle Bouzigon,Simon Heath,Erika von Mutius,Martin Farrall,Mark Lathrop,William O.C.M. Cookson +9 more
TL;DR: A few common alleles are associated with disease risk at all ages and suggest a role for communication of epithelial damage to the adaptive immune system and activation of airway inflammation in asthma.
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Sergei V. Kotenko,Grant Gallagher,Vitaliy V. Baurin,Anita Lewis-Antes,Meiling Shen,Nital K. Shah,Jerome A. Langer,Faruk Sheikh,Harold Dickensheets,Raymond P. Donnelly +9 more
TL;DR: The identification of a ligand-receptor system that, upon engagement, leads to the establishment of an antiviral state and may contribute to antiviral or other defenses by a mechanism similar to, but independent of, type I IFNs.
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Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group
Romain Pauwels,Claes-Göran Löfdahl,Dirkje S. Postma,Anne E. Tattersfield,Paul M. O'Byrne,Peter J. Barnes,A Ullman +6 more
TL;DR: In patients who have persistent symptoms of asthma despite treatment with inhaled glucocorticoids, the addition of formoterol to budesonid therapy or the use of a higher dose of budesonide may be beneficial.
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