Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features
Niv Zmora,Niv Zmora,Gili Zilberman-Schapira,Jotham Suez,Uria Mor,Mally Dori-Bachash,Stavros Bashiardes,Eran Kotler,Maya Zur,Dana Regev-Lehavi,Rotem Ben-Zeev Brik,Sara Federici,Yotam Cohen,Raquel Linevsky,Daphna Rothschild,Andreas E. Moor,Shani Ben-Moshe,Alon Harmelin,Shalev Itzkovitz,Nitsan Maharshak,Nitsan Maharshak,Oren Shibolet,Oren Shibolet,Hagit Shapiro,Meirav Pevsner-Fischer,Itai Sharon,Zamir Halpern,Zamir Halpern,Eran Segal,Eran Elinav +29 more
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TLDR
The metagenomically characterized the murine and human mucosal-associated gastrointestinal microbiome and found it to only partially correlate with stool microbiome, indicating that empiric probiotics supplementation may be limited in universally and persistently impacting the gut mucosa.About:
This article is published in Cell.The article was published on 2018-09-06 and is currently open access. It has received 900 citations till now. The article focuses on the topics: Gastrointestinal Microbiome & Microbiome.read more
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Targeting the microbiome: from probiotics to fecal microbiota transplantation.
TL;DR: The modern techniques of microbiome science can be applied to the development and evaluation of all microbiota-directed products, including probiotics and fecal microbiota transplantation.
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Ecological modelling approaches for predicting emergent properties in microbial communities
Naomi Iris van den Berg,Daniel Machado,S. Santoso,Isabel Rocha,Jeremy M. Chacón,William R. Harcombe,Sara Mitri,Kiran Raosaheb Patil +7 more
TL;DR: A review of ecosystem modelling approaches from the viewpoint of emergent properties can be found in this paper , where the authors consider the scope, advantages and limitations of Lotka-Volterra, consumer-resource, trait-based, individual-based and genome-scale metabolic models.
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Higher-Order Interactions Dampen Pairwise Competition in the Zebrafish Gut Microbiome.
Deepika Sundarraman,Edouard A. Hay,Dylan Martins,Drew S. Shields,Noah L. Pettinari,Raghuveer Parthasarathy +5 more
TL;DR: This work examines commensal intestinal microbes in larval zebrafish to allow the introduction of controlled combinations of bacterial species, and demonstrates the construction of communities of one to five bacterial species and shows that the outcomes from the two-species competitions fail to predict species abundances in more complex communities.
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Connecting the Dots Between Inflammatory Bowel Disease and Metabolic Syndrome: A Focus on Gut-Derived Metabolites.
TL;DR: This review focuses on the overlap between IBD and MetS, and the role of common metabolites in each disease is explored in an attempt to connect a common origin, the gut microbiome and derived metabolites that affect the gut, liver and pancreas.
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Bacteriophages: Uncharacterized and Dynamic Regulators of the Immune System.
Anshul Sinha,Corinne F. Maurice +1 more
TL;DR: An overview of bacteriophage communities in the gut during human development is provided, detailing recent findings for their bacterial-mediated effects on the immune response and summarizing the latest evidence for direct interactions between them and the immune system are summarized.
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