J
John Q. Trojanowski
Researcher at University of Pennsylvania
Publications - 1538
Citations - 245534
John Q. Trojanowski is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Dementia & Alzheimer's disease. The author has an hindex of 226, co-authored 1467 publications receiving 213948 citations. Previous affiliations of John Q. Trojanowski include Vanderbilt University & University of California, San Francisco.
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Native and derivatized lectins for in vivo studies of neuronal connectivity and neuronal cell biology
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Epitopes located in spatially separate domains of each neurofilament subunit are present in Parkinson's disease Lewy bodies.
TL;DR: The results strongly suggest that the entire extent of each neurofilament subunit is found in Lewy bodies but that the neuro Filament subunits may be altered during the processing of these filaments intoLewy bodies.
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Predicting clinical decline and conversion to Alzheimer’s disease or dementia using novel Elecsys Aβ(1–42), pTau and tTau CSF immunoassays
Kaj Blennow,Kaj Blennow,Leslie M. Shaw,Erik Stomrud,Niklas Mattsson,Jon B. Toledo,Jon B. Toledo,Katharina Buck,Simone Wahl,Udo Eichenlaub,Valeria Lifke,Maryline Simon,John Q. Trojanowski,Oskar Hansson +13 more
TL;DR: Elecsys pTau/Aβ(1–42) and tT Tau/A β(1-42) are robust biomarkers for predicting risk of clinical decline and conversion to dementia in non-demented patients, and may support AD diagnosis in clinical practice.
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Interactions of amyloidogenic proteins
TL;DR: Results indicate that the formation of amyloid composed of different proteins can affect each other directly or indirectly, likely contributing to the overlap in clinical and pathological features.