J
John Q. Trojanowski
Researcher at University of Pennsylvania
Publications - 1538
Citations - 245534
John Q. Trojanowski is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Dementia & Alzheimer's disease. The author has an hindex of 226, co-authored 1467 publications receiving 213948 citations. Previous affiliations of John Q. Trojanowski include Vanderbilt University & University of California, San Francisco.
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Journal ArticleDOI
Disruption of large-scale neural networks in non-fluent/agrammatic variant primary progressive aphasia associated with frontotemporal degeneration pathology
Murray Grossman,John Powers,Sherry Ash,Corey T. McMillan,Lisa Burkholder,David J. Irwin,John Q. Trojanowski +6 more
TL;DR: Non-fluent/agrammatic primary progressive aphasia is a progressive neurodegenerative condition most prominently associated with slowed, effortful speech, and large-scale neural networks underlying effortful expression are assessed in patients with sporadic naPPA.
Journal ArticleDOI
Phosphorylated neurofilament heavy chain: A biomarker of survival for C9ORF72-associated amyotrophic lateral sclerosis
Tania F. Gendron,Lillian M. Daughrity,Michael G. Heckman,Nancy N. Diehl,Joanne Wuu,Timothy M. Miller,Pau Pastor,John Q. Trojanowski,Murray Grossman,James D. Berry,William T. Hu,Antonia Ratti,Michael Benatar,Vincenzo Silani,Jonathan D. Glass,Mary Kay Floeter,Andreas Jeromin,Kevin B. Boylan,Leonard Petrucelli +18 more
TL;DR: It is shown that levels of phosphorylated neurofilament heavy chain (pNFH) in cerebrospinal fluid (CSF) predict disease status and survival in c9ALS patients, and are largely stable over time.
Journal ArticleDOI
Amyloid plaques in cerebellar cortex and the integrity of Purkinje cell dendrites
TL;DR: Despite the abundance of A beta deposits in the cerebellar cortex of AD and older DS patients, neither PC bodies nor PC dendrites in physical contact with A beta lesions showed evidence of structural abnormalities.
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Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD.
Cyril Pottier,Yingxue Ren,Ralph B. Perkerson,Matt Baker,Gregory D. Jenkins,Marka van Blitterswijk,Mariely DeJesus-Hernandez,Jeroen van Rooij,Melissa E. Murray,Elizabeth Christopher,Shannon K. McDonnell,Zachary C. Fogarty,Anthony Batzler,Shulan Tian,Cristina T. Vicente,Billie J. Matchett,Anna Karydas,Ging-Yuek Robin Hsiung,Harro Seelaar,Merel O. Mol,Elizabeth Finger,Caroline Graff,Linn Öijerstedt,Manuela Neumann,Manuela Neumann,Peter Heutink,Peter Heutink,Matthis Synofzik,Matthis Synofzik,Carlo Wilke,Carlo Wilke,Johannes Prudlo,Johannes Prudlo,Patrizia Rizzu,Javier Simón-Sánchez,Javier Simón-Sánchez,Dieter Edbauer,Sigrun Roeber,Janine Diehl-Schmid,Bret M. Evers,Andy King,Andy King,M.-Marsel Mesulam,Sandra Weintraub,Changiz Geula,Kevin F. Bieniek,Kevin F. Bieniek,Leonard Petrucelli,Geoffrey L. Ahern,Eric M. Reiman,Bryan K. Woodruff,Richard J. Caselli,Edward D. Huey,Martin R. Farlow,Jordan Grafman,Simon Mead,Lea T. Grinberg,Salvatore Spina,Murray Grossman,David J. Irwin,Edward B. Lee,EunRan Suh,Julie S. Snowden,David G. Mann,Nilufer Ertekin-Taner,Ryan J. Uitti,Zbigniew K. Wszolek,Keith A. Josephs,Joseph E. Parisi,David S. Knopman,Ronald C. Petersen,John R. Hodges,Olivier Piguet,Ethan G. Geier,Jennifer S. Yokoyama,Robert A. Rissman,Ekaterina Rogaeva,Julia Keith,Lorne Zinman,Maria Carmela Tartaglia,Maria Carmela Tartaglia,Nigel J. Cairns,Carlos Cruchaga,Bernardino Ghetti,Julia Kofler,Oscar L. Lopez,Oscar L. Lopez,Thomas G. Beach,Thomas Arzberger,Thomas Arzberger,Jochen Herms,Jochen Herms,Lawrence S. Honig,Jean Paul G. Vonsattel,Glenda M. Halliday,Glenda M. Halliday,John B.J. Kwok,John B.J. Kwok,Charles L. White,Marla Gearing,Jonathan D. Glass,Sara Rollinson,Stuart Pickering-Brown,Jonathan D. Rohrer,John Q. Trojanowski,Vivianna M. Van Deerlin,Eileen H. Bigio,Claire Troakes,Safa Al-Sarraj,Safa Al-Sarraj,Yan W. Asmann,Bruce L. Miller,Neill R. Graff-Radford,Bradley F. Boeve,William W. Seeley,Ian R. A. Mackenzie,John C. van Swieten,Dennis W. Dickson,Joanna M. Biernacka,Rosa Rademakers +119 more
TL;DR: A possible role for genes functioning within the TBK1-related immune pathway (e.g., DHX58, TRIM21, IRF7) in the genetic etiology of FTLD-TDP is discovered and strongly implicates the immune pathway in FTLD/TDP pathogenesis.
Journal ArticleDOI
Longitudinal decline in autopsy-defined frontotemporal lobar degeneration.
Murray Grossman,Sharon X. Xie,David J. Libon,X. Wang,Lauren Massimo,Peachie Moore,Luisa Vesely,R. Berkowitz,Anjan Chatterjee,H. B. Coslett,Howard I. Hurtig,Mark S. Forman,Virginia M.-Y. Lee,John Q. Trojanowski +13 more
TL;DR: Moves consistently distinguishing between patient subgroups can be used to bolster diagnostic accuracy throughout the course of these diseases, while measures demonstrating undifferentiated longitudinal decline may serve as useful endpoints in treatment trials.