J
John Q. Trojanowski
Researcher at University of Pennsylvania
Publications - 1538
Citations - 245534
John Q. Trojanowski is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Dementia & Alzheimer's disease. The author has an hindex of 226, co-authored 1467 publications receiving 213948 citations. Previous affiliations of John Q. Trojanowski include Vanderbilt University & University of California, San Francisco.
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Journal ArticleDOI
Expression patterns of β‐amyloid precursor protein (β‐APP) in neural and nonneural human tissues from alzheimer's disease and control subjects
Hiroyuki Arai,Virginia M.-Y. Lee,Meridith L. Messinger,Barry D. Greenberg,David E. Lowery,John Q. Trojanowski +5 more
TL;DR: β‐APPs produced in the brain are sources of β‐APP peptides that accumulate as senile plaques in AD, and are detectable only in a limited number of nonneural tissues.
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An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer's disease.
Raffaella Nativio,Yemin Lan,Greg Donahue,Simone Sidoli,Simone Sidoli,Amit Berson,Ananth R. Srinivasan,Oksana Shcherbakova,Alexandre Amlie-Wolf,Ji Nie,Xiaolong Cui,Chuan He,Li-San Wang,Benjamin A. Garcia,John Q. Trojanowski,Nancy M. Bonini,Shelley L. Berger +16 more
TL;DR: It is suggested that Alzheimer’s disease involves a reconfiguration of the epigenome, where H3K27ac and H3k9ac impact disease pathways by dysregulating transcription- and chromatin-gene feedback loops and highlights potential epigenetic strategies for early-stage disease treatment.
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Conjugates of horseradish peroxidase (HRP) with cholera toxin and wheat germ agglutinin are superior to free HRP as orthogradely transported markers
TL;DR: The relative sensitivity of horseradish peroxidase (HRP) conjugates of cholera toxin and wheat germ agglutinin as orthogradely transported markers was compared with that of free HRP following unilateral, intravitreal injections of each probe in the rat.
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Cognitive decline and reduced survival in C9orf72 expansion frontotemporal degeneration and amyotrophic lateral sclerosis
David J. Irwin,Corey T. McMillan,Johannes Brettschneider,Johannes Brettschneider,David J. Libon,David J. Libon,John Powers,Katya Rascovsky,Jon B. Toledo,Ashley Boller,Jonathan M. Bekisz,Keerthi Chandrasekaran,Elisabeth M. Wood,Elisabeth M. Wood,Leslie M. Shaw,John H. Woo,Philip A. Cook,David A. Wolk,Steven E. Arnold,Steven E. Arnold,Vivianna M. Van Deerlin,Leo McCluskey,Lauren Elman,Virginia M.-Y. Lee,Virginia M.-Y. Lee,John Q. Trojanowski,John Q. Trojanowski,Murray Grossman +27 more
TL;DR: C9P cases may have a shorter survival in ALS and more rapid rate of cognitive decline related to frontal and parietal disease in FTLD, and C9orf72 genotyping may provide useful prognostic and diagnostic clinical information for patients with ALS and FTLD.
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Association between in vivo fluorine 18-labeled flutemetamol amyloid positron emission tomography imaging and in vivo cerebral cortical histopathology.
David A. Wolk,Igor D. Grachev,Christopher Buckley,Hala Kazi,M. Sean Grady,John Q. Trojanowski,Roy H. Hamilton,Paul Sherwin,Richard McLain,Steven E. Arnold +9 more
TL;DR: These data are the first to demonstrate the concordance of ¹⁸F-flutemetamol PET imaging with histopathology, supporting its sensitivity to detect amyloid and potential use in the study and detection of Alzheimer disease.