John Q. Trojanowski

TL;DR: It is concluded that pallido-ponto-nigral degeneration is a hereditary neurodegenerative disorder characterized by neuronal and glial tau-rich inclusions formed from aggregated filaments and hyperphosphorylated tau proteins and can be subcategorized into the tauopathy group of chromosome 17-linked neurodegenersative disorders.

TL;DR: Tau-positive glial lesions similar to human FTDs occur in these Tg mice, and these pathologies are linked to glial and axonal degeneration.

TL;DR: Four atrophy patterns are identified that effectively define a 4-dimensional categorization of neuroanatomical alterations in mild cognitive impairment and Alzheimer's disease that can complement existing dimensional approaches for staging Alzheimer’s disease using a variety of biomarkers, which offer the potential for enabling precision diagnostics and prognostics, as well as targeted patient recruitment of relatively homogeneous subgroups of subjects for clinical trials.

TL;DR: It is demonstrated that autografted chromaffin cells can survive for 4 months after transplantation and that related changes in dopamine receptors can be quantified.

TL;DR: It is demonstrated a wider distribution of CG than previously recognized and that the molecule detected in tissue by immunohistochemistry is indeed CG, and it is concluded that CG is expressed by neurons, cells of the DNS, and by a few other cells that may or may not be related to the DNS.