J
John Q. Trojanowski
Researcher at University of Pennsylvania
Publications - 1538
Citations - 245534
John Q. Trojanowski is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Dementia & Alzheimer's disease. The author has an hindex of 226, co-authored 1467 publications receiving 213948 citations. Previous affiliations of John Q. Trojanowski include Vanderbilt University & University of California, San Francisco.
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Parkinson's disease and related synucleinopathies are a new class of nervous system amyloidoses.
TL;DR: Dramatic new insights into the role of alpha-synuclein (AS) in the pathobiology of PD have emerged recently, and this has led to the development of transgenic animal models of PD-like AS pathologies.
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Phosphorylated Tau as a Candidate Biomarker for Amyotrophic Lateral Sclerosis
Murray Grossman,Lauren Elman,Leo McCluskey,Corey T. McMillan,Ashley Boller,John Powers,Katya Rascovsky,William T. Hu,Les Shaw,David J. Irwin,Virginia M.-Y. Lee,John Q. Trojanowski +11 more
TL;DR: The CSF ptau:ttau ratio may be a candidate biomarker to provide objective support for the diagnosis of ALS and is related with clinical measures of disease severity.
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Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease
Thomas J. Montine,Sarah E. Monsell,Thomas G. Beach,Eileen H. Bigio,Yunqi Bu,Nigel J. Cairns,Matthew P. Frosch,Jonathan Henriksen,Julia Kofler,Walter A. Kukull,Edward B. Lee,Peter T. Nelson,Aimee Schantz,Julie A. Schneider,Joshua A. Sonnen,John Q. Trojanowski,Harry V. Vinters,Xiao Hua Zhou,Bradley T. Hyman +18 more
TL;DR: Neuropathologic assessment is the current “gold standard” for evaluating the Alzheimer's disease (AD), but there is no consensus on the methods used.
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Proteasome Inhibition Stabilizes Tau Inclusions in Oligodendroglial Cells that Occur after Treatment with Okadaic Acid
Olaf Goldbaum,Malte Oppermann,Melanie Handschuh,Deepa Dabir,Bin Zhang,Mark S. Forman,John Q. Trojanowski,Virginia M.-Y. Lee,Christiane Richter-Landsberg +8 more
TL;DR: It is shown by immunohistochemistry that tau-positive oligodendroglial inclusion bodies also contain the small heat-shock protein (HSP) αB-crystallin but not HSP70, and only hyperphosporylation of tau followed by proteasome inhibition leads to stable fibrillary deposits of tAU similar to those observed in neurodegenerative diseases.
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Tau Proteins Are Abnormally Expressed in Olfactory Epithelium of Alzheimer Patients and Developmentally Regulated in Human Fetal Spinal Cord
TL;DR: It is demonstrated that many of the epitopes present in the dystrophic neurites of AD are expressed early in the developing spinal cord and are later extinguished, including adult tau epitopespresent in the brain.