J
John Q. Trojanowski
Researcher at University of Pennsylvania
Publications - 1538
Citations - 245534
John Q. Trojanowski is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Dementia & Alzheimer's disease. The author has an hindex of 226, co-authored 1467 publications receiving 213948 citations. Previous affiliations of John Q. Trojanowski include Vanderbilt University & University of California, San Francisco.
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Journal ArticleDOI
Dysregulation of olfactory receptor neuron lineage in schizophrenia.
Steven E. Arnold,Li-Ying Han,Paul J. Moberg,Bruce I. Turetsky,Raquel E. Gur,John Q. Trojanowski,Chang-Gyu Hahn +6 more
TL;DR: Abnormal densities and ratios of OE neurons at different stages of development indicate dysregulation of Oe neuronal lineage in schizophrenia, which could be because of intrinsic factors controlling differentiation or an inability to gain trophic support from axonal targets in the olfactory bulb.
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Modulation of axon diameter and neurofilaments by hypomyelinating Schwann cells in transgenic mice.
TL;DR: Analysis of peripheral nerves in two different lines of hypomyelinating transgenic mice provides strong evidence indicating that myelinating Schwann cells exert a significant influence on axon caliber by modulating NF phosphorylation and NF packing density in the axons of peripheral nerve.
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Circulating brain-enriched microRNAs as novel biomarkers for detection and differentiation of neurodegenerative diseases
Kira S. Sheinerman,Jon B. Toledo,Jon B. Toledo,Vladimir G. Tsivinsky,David J. Irwin,Murray Grossman,Daniel Weintraub,Howard I. Hurtig,Alice Chen-Plotkin,David A. Wolk,Leo McCluskey,Lauren Elman,John Q. Trojanowski,Samuil R. Umansky +13 more
TL;DR: The assessment of circulating brain-enriched microRNAs as potential biomarkers for Alzheimer’s disease, frontotemporal dementia, Parkinson's disease, and amyotrophic lateral sclerosis suggests the possibility of developing microRNA-based diagnostics for detection and differentiation of NDs.
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Inflammatory hypotheses: novel mechanisms of Alzheimer's neurodegeneration and new therapeutic targets?
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Clinical and Biochemical Differences in Patients Having Parkinson Disease With vs Without GBA Mutations
Lama M. Chahine,Judy Qiang,Emily Ashbridge,James Minger,Dora Yearout,Stacy Horn,Amy Colcher,Howard I. Hurtig,Virginia M.-Y. Lee,Vivianna M. Van Deerlin,James B. Leverenz,Andrew Siderowf,John Q. Trojanowski,Cyrus P. Zabetian,Alice Chen-Plotkin +14 more
TL;DR: Patients having PD with GBA mutations have earlier age at disease onset and are more likely to demonstrate cognitive dysfunction, and monocyte-associated inflammatory mediators may be elevated in patients havingPD with G BA mutations.