J
John Q. Trojanowski
Researcher at University of Pennsylvania
Publications - 1538
Citations - 245534
John Q. Trojanowski is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Dementia & Alzheimer's disease. The author has an hindex of 226, co-authored 1467 publications receiving 213948 citations. Previous affiliations of John Q. Trojanowski include Vanderbilt University & University of California, San Francisco.
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Journal ArticleDOI
Molecular dissection of TrkA signal transduction pathways mediating differentiation in human neuroblastoma cells
Angelika Eggert,Angelika Eggert,Naohiko Ikegaki,Naohiko Ikegaki,Xing Ge Liu,Xing Ge Liu,Thomas T. Chou,Virginia M.-Y. Lee,John Q. Trojanowski,Garrett M. Brodeur,Garrett M. Brodeur +10 more
TL;DR: Analysis of downstream signal transduction pathways indicated that NGF-induced differentiation was dependent on TrkA kinase activity, and activation of the RAS/MAPK signaling pathway seems to be of major importance for NGF mediated differentiation of NB cells.
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Twofold overexpression of human beta-amyloid precursor proteins in transgenic mice does not affect the neuromotor, cognitive, or neurodegenerative sequelae following experimental brain injury.
Hisayuki Murai,Jean E.S. Pierce,Ramesh Raghupathi,Douglas H. Smith,Kathryn E. Saatman,John Q. Trojanowski,Virginia M.-Y. Lee,Jeanne F. Loring,Chris Eckman,Steven G. Younkin,Tracy K. McIntosh +10 more
TL;DR: The data show that the APP‐YAC mice do not develop AD‐like neuropathology following traumatic brain injury, and this injury does not induce elevated levels of the more amyloidogenic forms of human Aβ in these mice.
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Biomarkers for early detection of Alzheimer pathology.
Christopher M. Clark,Christos Davatzikos,Arijitt Borthakur,A. Newberg,Susan Leight,Virginia M.-Y. Lee,John Q. Trojanowski +6 more
TL;DR: Success will facilitate the ability to reliably diagnose Alzheimer’s disease while the symptoms of brain failure are mild and may provide objective measures of disease-modifying treatment efficacy.
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Tau-directed drug discovery for Alzheimer's disease and related tauopathies: a focus on tau assembly inhibitors.
Kurt R. Brunden,Carlo Ballatore,Alex Crowe,Amos B. Smith,Virginia M.-Y. Lee,John Q. Trojanowski +5 more
TL;DR: Recent advances in tau-based drug discovery are reviewed, with an emphasis on the identification of compounds that inhibit the assembly of tau into multimers and fibrils.
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Genetically modified NT2N human neuronal cells mediate long-term gene expression as CNS grafts in vivo and improve functional cognitive outcome following experimental traumatic brain injury
Deborah Watson,Luca Longhi,Edward B. Lee,Carl T. Fulp,Scott Fujimoto,Nicolas C. Royo,Marco A. Passini,John Q. Trojanowski,Virginia M.-Y. Lee,Tracy K. McIntosh,John H. Wolfe +10 more
TL;DR: Stable, efficient, and nontoxic gene transfer into undifferentiated NT2 cells using a pseudotyped lentiviral vector encoding the human elongation factor 1-α promoter and the reporter gene eGFP is demonstrated.