J
John Q. Trojanowski
Researcher at University of Pennsylvania
Publications - 1538
Citations - 245534
John Q. Trojanowski is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Dementia & Alzheimer's disease. The author has an hindex of 226, co-authored 1467 publications receiving 213948 citations. Previous affiliations of John Q. Trojanowski include Vanderbilt University & University of California, San Francisco.
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Synucleins are expressed in the majority of breast and ovarian carcinomas and in preneoplastic lesions of the ovary.
Wendy Bruening,Benoit I. Giasson,Andres J. P. Klein-Szanto,Virginia M.-Y. Lee,John Q. Trojanowski,Andrew K. Godwin +5 more
TL;DR: Examination of a panel of breast and ovarian carcinomas for expression of α, β, and γ synucleins found that α synuclein has attracted considerable attention due to its involvement in neurodegenerative diseases.
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TMEM106B, the Risk Gene for Frontotemporal Dementia, Is Regulated by the microRNA-132/212 Cluster and Affects Progranulin Pathways
Alice Chen-Plotkin,Travis L. Unger,Michael D. Gallagher,Emily Bill,Linda K. Kwong,Laura A. Volpicelli-Daley,Johanna I. Busch,Sebastian Akle,Murray Grossman,Vivianna M. Van Deerlin,John Q. Trojanowski,Virginia M.-Y. Lee +11 more
TL;DR: TMEM106B is neuronally expressed in postmortem human brain tissue, and that expression levels are increased in FTLD-TDP brain, and microRNA-132/212 depression as an event which can lead to aberrant overexpression of TMEM 106B, which in turn alters progranulin pathways.
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Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy.
Krista Spiller,Clark R. Restrepo,Tahiyana Khan,Myrna A. Dominique,Terry C. Fang,Rebecca G. Canter,Chris Roberts,Kelly R. Miller,Richard M. Ransohoff,John Q. Trojanowski,Virginia M.-Y. Lee +10 more
TL;DR: Using an inducible mouse model of sporadic ALS, Spiller et al. show that spinal microgliosis is not a major feature of TDP-43-triggered disease, and microglia mediate T DP-43 clearance and motor recovery, suggesting a neuroprotective role in ALS.
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Tau pathology in a family with dementia and a P301L mutation in tau.
Suzanne S. Mirra,Jill R. Murrell,Marla Gearing,Maria Grazia Spillantini,Michel Goedert,R. Anthony Crowther,Allan I. Levey,Randi Jones,Joanne Green,John M. Shoffner,Bruce H. Wainer,Marie L. Schmidt,John Q. Trojanowski,Bernardino Ghetti +13 more
TL;DR: The findings on 2 affected siblings from a family with early-onset dementia, characterized by extensive tau pathology and a Pro to Leu mutation at codon 301 of tau, emphasize the phenotypic and genetic heterogeneity of tAUopathies and highlight intriguing links between FTDP-17 and other neurodegenerative diseases.
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Paired helical filament tau (PHFtau) in Niemann-Pick type C disease is similar to PHFtau in Alzheimer's disease.
I. A. Auer,Marie L. Schmidt,Virginia M.-Y. Lee,B. Curry,Kinuko Suzuki,Ryong-Woon Shin,Peter G. Pentchev,E D Carstea,John Q. Trojanowski +8 more
TL;DR: It is speculated, that the generation of PHFtau in NPC may induce a cascade of pathological events that contribute to the widespread degeneration of neurons, and that these events may be similar in NPC and AD.