J
John Q. Trojanowski
Researcher at University of Pennsylvania
Publications - 1538
Citations - 245534
John Q. Trojanowski is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Dementia & Alzheimer's disease. The author has an hindex of 226, co-authored 1467 publications receiving 213948 citations. Previous affiliations of John Q. Trojanowski include Vanderbilt University & University of California, San Francisco.
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Journal ArticleDOI
Vitamin E reduces amyloidosis and improves cognitive function in Tg2576 mice following repetitive concussive brain injury
Valeria Conte,Kunihiro Uryu,Scott Fujimoto,Scott Fujimoto,Yuemang Yao,Joshua Rokach,Luca Longhi,Luca Longhi,John Q. Trojanowski,Virginia M.-Y. Lee,Tracy K. McIntosh,Tracy K. McIntosh,Domenico Praticò +12 more
TL;DR: It is suggested that the exacerbation of brain oxidative stress following RCBI plays a mechanistic role in accelerating Αβ accumulation and behavioral impairments in the Tg2576 mice.
Journal ArticleDOI
Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer's Disease Neuroimaging Initiative.
Thomas K. Karikari,Andrea Lessa Benedet,Nicholas J. Ashton,Juan Lantero Rodriguez,Anniina Snellman,Anniina Snellman,Marc Suárez-Calvet,Paramita Saha-Chaudhuri,Firoza Z. Lussier,Hlin Kvartsberg,Hlin Kvartsberg,Alexis Moscoso Rial,Tharick A. Pascoal,Tharick A. Pascoal,Ulf Andreasson,Ulf Andreasson,Michael Schöll,Michael Schöll,Michael W. Weiner,Pedro Rosa-Neto,Pedro Rosa-Neto,John Q. Trojanowski,Leslie M. Shaw,Kaj Blennow,Kaj Blennow,Henrik Zetterberg,Alzheimer’s Disease Neuroimaging Initiative +26 more
TL;DR: This study adds significant weight to the growing body of evidence in the use of plasma p-tau181 as a non-invasive diagnostic and prognostic tool for AD, regardless of clinical stage, which would be of great benefit in clinical practice and a large cost-saving in clinical trial recruitment.
Journal Article
Epitope map of neurofilament protein domains in cortical and peripheral nervous system Lewy bodies.
Marie L. Schmidt,John M. Murray,Virginia M.-Y. Lee,William D. Hill,A. M. Wertkin,John Q. Trojanowski +5 more
TL;DR: The accumulation of filamentous, perikaryal inclusions rich in NF proteins at diverse sites in the CNS and PNS of patients with a variety of neurodegenerative disorders suggests a widespread disruption of NF metabolism or transport.
Journal ArticleDOI
GBA Variants are associated with a distinct pattern of cognitive deficits in Parkinson's disease.
Ignacio F. Mata,James B. Leverenz,Daniel Weintraub,Daniel Weintraub,John Q. Trojanowski,Alice Chen-Plotkin,Vivianna M. Van Deerlin,Beate Ritz,Rebecca Rausch,Stewart A. Factor,Cathy Wood-Siverio,Joseph F. Quinn,Kathryn A. Chung,Amie L. Peterson-Hiller,Jennifer G. Goldman,Glenn T. Stebbins,Bryan Bernard,Alberto J. Espay,Fredy J. Revilla,Fredy J. Revilla,Johnna Devoto,Liana S. Rosenthal,Ted M. Dawson,Marilyn S. Albert,Debby W. Tsuang,Haley Huston,Dora Yearout,Shu Ching Hu,Brenna Cholerton,Thomas J. Montine,Karen L. Edwards,Cyrus P. Zabetian +31 more
TL;DR: Loss‐of‐function mutations in the GBA gene are associated with more severe cognitive impairment in PD, but the nature of these deficits is not well understood and whether common GBA polymorphisms influence cognitive performance in PD is not yet known.
Journal ArticleDOI
Spread of α-synuclein pathology through the brain connectome is modulated by selective vulnerability and predicted by network analysis.
Michael X. Henderson,Eli J. Cornblath,Adam Darwich,Bin Zhang,Hannah J. Brown,Ronald J. Gathagan,Raizel M. Sandler,Danielle S. Bassett,John Q. Trojanowski,Virginia M.-Y. Lee +9 more
TL;DR: In this paper, the authors used quantitative pathology mapping in the mouse brain, combined with network modeling to understand the spatiotemporal pattern of spread of pathogenic proteins and neuron death observed in patients.