J
John Q. Trojanowski
Researcher at University of Pennsylvania
Publications - 1538
Citations - 245534
John Q. Trojanowski is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Dementia & Alzheimer's disease. The author has an hindex of 226, co-authored 1467 publications receiving 213948 citations. Previous affiliations of John Q. Trojanowski include Vanderbilt University & University of California, San Francisco.
Papers
More filters
Journal ArticleDOI
Neurons Derived from a Human Teratocarcinoma Cell Line Establish Molecular and Structural Polarity Following Transplantation into the Rodent Brain
John Q. Trojanowski,John R. Mantione,Jae Hong Lee,Derice P. Seid,Timothy You,Landon J. Inge,Virginia M.-Y. Lee +6 more
TL;DR: It is concluded that transplanted NT2N cells represent a highly advantageous model system for studies of the developmental biology of neurons and their ability to establish molecular and structural polarity.
Journal ArticleDOI
Pesticide Exposure Exacerbates α-Synucleinopathy in an A53T Transgenic Mouse Model
Erin H. Norris,Kunihiro Uryu,Susan Leight,Benoit I. Giasson,John Q. Trojanowski,Virginia M.-Y. Lee +5 more
TL;DR: The notion that environmental factors causing nitrative damage are closely linked to mechanisms underlying the formation of α-synuclein pathologies and the onset of Parkinson's-like neurodegeneration is supported.
Journal ArticleDOI
Plasma amyloid beta measurements - a desired but elusive Alzheimer's disease biomarker
TL;DR: It is concluded that further clinical research and assay development are needed before measures of plasma Aβ can be interpreted so they can be applied as trait, risk or state biomarkers for AD.
Journal ArticleDOI
Brain Microvascular Pericytes in Vascular Cognitive Impairment and Dementia.
TL;DR: How dysfunctional pericytes contribute to the pathogenesis of vascular cognitive impairment including cerebral ‘small vessel’ and ‘large vessel” diseases, as well as AD is focused on.
Journal ArticleDOI
Aluminum modifies the properties of Alzheimer's disease PHF tau proteins in vivo and in vitro
TL;DR: In vivo interactions of PHF tau and aluminum chloride (AlCl3) with other plaque and tangle components are investigated and suggest that aluminum binds to PHf tau, induces these proteins to aggregate, and retards their proteolysis.