J
John Q. Trojanowski
Researcher at University of Pennsylvania
Publications - 1538
Citations - 245534
John Q. Trojanowski is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Dementia & Alzheimer's disease. The author has an hindex of 226, co-authored 1467 publications receiving 213948 citations. Previous affiliations of John Q. Trojanowski include Vanderbilt University & University of California, San Francisco.
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Transactive response DNA-binding protein 43 burden in familial Alzheimer disease and Down syndrome.
Carol F. Lippa,Andrea L. Rosso,Lauren D. Stutzbach,Manuela Neumann,Manuela Neumann,Virginia M.-Y. Lee,John Q. Trojanowski +6 more
TL;DR: Transactive response DNA-binding protein 43 pathology occurs in FAD and DS, similar to that observed in sporadic Alzheimer disease, and may contribute the cognitive impairments in familial and sporadic forms of Alzheimer disease.
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Neurofibrillary tangles in progressive supranuclear palsy contain the same tau epitopes identified in Alzheimer's disease PHFtau.
Marie L. Schmidt,Richard Huang,J. Martin,Jewel Henley,Madhumalti Mawal-Dewan,Howard I. Hurtig,Virginia M.-Y. Lee,John Q. Trojanowski +7 more
TL;DR: Despite differences in the distribution, ultrastructure and immunoblot profile of NFTs in PSP and AD, the same constellation of tau epitopes is present in the abnormal tau proteins in PSP (PSPtau) and AD N FTs.
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Long-term deep brain stimulation in a patient with essential tremor: Clinical response and postmortem correlation with stimulator termination sites in ventral thalamus. Case report
John A. Boockvar,Albert E. Telfeian,Gordon H. Baltuch,Brett E. Skolnick,Tanya Simuni,Matthew B. Stern,Marie L. Schmidt,John Q. Trojanowski +7 more
TL;DR: It is believed that suppression of essential tremor by chronic DBS correlates with bilateral termination of the stimulators in the Vim region of the thalamus.
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Neurofilament mRNA is reduced in Parkinson's disease substantia nigra pars compacta neurons.
TL;DR: The results suggest that the formation of neurofilament‐rich Lewy bodies in substantia nigra pars compacta neurons is associated with reduced levels of the heavy and light neurofilaments mRNAs in Parkinson's disease.
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Semi-automated quantification of C9orf72 expansion size reveals inverse correlation between hexanucleotide repeat number and disease duration in frontotemporal degeneration
EunRan Suh,Edward B. Lee,Donald E. Neal,Elisabeth M. Wood,Jon B. Toledo,Lior Rennert,David J. Irwin,Corey T. McMillan,Bryan L. Krock,Lauren Elman,Leo McCluskey,Murray Grossman,Sharon X. Xie,John Q. Trojanowski,Vivianna M. Van Deerlin +14 more
TL;DR: Semi-automated expansion size measurements demonstrated an inverse relationship between C9orf72 expansion size and disease duration in patients with FTD, suggesting that C 9orf72 repeat size may be a molecular disease modifier in FTD linked to hexanucleotide repeat expansion.