John Q. Trojanowski

TL;DR: The observations of the cotransport of multiple SCb proteins in single axons suggest that they move as multiprotein complexes, and these studies offer novel mechanistic insights into SCb and provide tools for further investigating its role in disease processes.

TL;DR: Patients with the c.26C>A mutation appeared to have a younger age at onset of FTLD and at death and more parkinsonian features than those with other GRN mutations, which differs in key features from GRN- FTLD-TDP.

TL;DR: It is found that overexpression of miR-203, a hub of a putative regulatory microRNA (miRNA) module, recapitulates mRNA coexpression patterns associated with disease state and induces neuronal cell death, establishing this miRNA as a regulator of neurodegeneration.

TL;DR: Phonologic loop dysfunction is a central feature of AD-associated PPA and specifically correlates with temporoparietal neurodegeneration.

TL;DR: Assessment of α-synuclein in cerebrospinal fluid and its association with CSF total tau, phosphorylated tau181, and amyloid beta1-42 in subjects of the Alzheimer’s Disease Neuroimaging Initiative (ADNI) with longitudinal clinical assessments suggests inclusion of measures of CSF α- Syn improves the diagnostic sensitivity/specificity of classic CSF AD biomarkers and better predicts longitudinal cognitive changes.