J
John Q. Trojanowski
Researcher at University of Pennsylvania
Publications - 1538
Citations - 245534
John Q. Trojanowski is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Dementia & Alzheimer's disease. The author has an hindex of 226, co-authored 1467 publications receiving 213948 citations. Previous affiliations of John Q. Trojanowski include Vanderbilt University & University of California, San Francisco.
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Journal ArticleDOI
Features of Patients With Nonfluent/Agrammatic Primary Progressive Aphasia With Underlying Progressive Supranuclear Palsy Pathology or Corticobasal Degeneration
Miguel A. Santos-Santos,Miguel A. Santos-Santos,Maria Luisa Mandelli,Richard J. Binney,Jennifer M. Ogar,Stephen M. Wilson,Maya L. Henry,H. Isabel Hubbard,Minerva Meese,Suneth Attygalle,Lynne Rosenberg,Mikhail Pakvasa,John Q. Trojanowski,Lea T. Grinberg,Howie Rosen,Adam L. Boxer,Bruce L. Miller,William W. Seeley,Maria Luisa Gorno-Tempini +18 more
TL;DR: In patients presenting with nfvPPA, presence of early severe dysarthria, relatively selective white matter atrophy at presentation, and a greater rate of change in the brainstem measured by longitudinal imaging may be useful for differentiating underlying PSP from CBD pathology during life.
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Mild traumatic brain injury induces apoptotic cell death in the cortex that is preceded by decreases in cellular Bcl-2 immunoreactivity.
Ramesh Raghupathi,Alana C. Conti,David I. Graham,Stanislaw Krajewski,John C. Reed,M.S. Grady,John Q. Trojanowski,Tracy K. McIntosh,Tracy K. McIntosh +8 more
TL;DR: It is suggested that apoptosis contributes to cell death in both gray and white matter, and that decreases in cellular Bcl-2 may, in part, be associated with both apoptotic and non-apoptotic cell death following mild brain trauma.
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α-Syn Suppression Reverses Synaptic and Memory Defects in a Mouse Model of Dementia with Lewy Bodies
Youngshin Lim,Victoria M. Kehm,Edward B. Lee,James H. Soper,Chi Li,John Q. Trojanowski,Virginia M.-Y. Lee +6 more
TL;DR: It is found that the distribution ofα-syn pathology in an inducible α-syn transgenic mouse model recapitulates that in human DLB, and when α- synuclein expression was suppressed, partial clearing of pre-existing α-Syn pathology and reversal of structural synaptic defects were observed, resulting in an improvement in memory function.
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TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions
Michael D. Gallagher,EunRan Suh,Murray Grossman,Lauren Elman,Leo McCluskey,John C. van Swieten,John C. van Swieten,Safa Al-Sarraj,Manuela Neumann,Manuela Neumann,Ellen Gelpi,Bernardino Ghetti,Jonathan D. Rohrer,Glenda M. Halliday,Glenda M. Halliday,Christine Van Broeckhoven,Danielle Seilhean,Pamela J. Shaw,Matthew P. Frosch,Irina Alafuzoff,Anna Antonell,Nenad Bogdanovic,William S. Brooks,William S. Brooks,Nigel J. Cairns,Johnathan Cooper-Knock,Carl W. Cotman,Patrick Cras,Marc Cruts,Marc Cruts,Peter Paul De Deyn,Charles DeCarli,Carol Dobson-Stone,Carol Dobson-Stone,Sebastiaan Engelborghs,Nick C. Fox,Douglas Galasko,Marla Gearing,Ilse Gijselinck,Ilse Gijselinck,Jordan Grafman,Päivi Hartikainen,Kimmo J. Hatanpaa,J. Robin Highley,John R. Hodges,John R. Hodges,Christine M. Hulette,Paul G. Ince,Lee-Way Jin,Janine Kirby,Julia Kofler,Jillian J. Kril,John B.J. Kwok,John B.J. Kwok,Allan I. Levey,Andrew P. Lieberman,Albert Lladó,Jean Jacques Martin,Eliezer Masliah,Christopher J McDermott,Ann C. McKee,Catriona McLean,Simon Mead,Carol A. Miller,Josh Miller,David G. Munoz,Jill R. Murrell,Henry L. Paulson,Olivier Piguet,Olivier Piguet,Martin N. Rossor,Raquel Sánchez-Valle,Mary Sano,Julie A. Schneider,Lisa C. Silbert,Salvatore Spina,Julie van der Zee,Julie van der Zee,Tim Van Langenhove,Tim Van Langenhove,Jason D. Warren,Stephen B. Wharton,Charles L. White,Randall L. Woltjer,John Q. Trojanowski,Virginia M.-Y. Lee,Vivianna M. Van Deerlin,Alice Chen-Plotkin +87 more
TL;DR: The genotype that confers increased risk for developing FTLD-TDP (major, or T, allele of rs1990622) is associated with later age at onset and death in C9orf72 expansion carriers, providing an example of sign epistasis in human neurodegenerative disease.
Journal ArticleDOI
Empiric refinement of the pathologic assessment of Lewy-related pathology in the dementia patient.
James B. Leverenz,Ronald L. Hamilton,Debby W. Tsuang,Debby W. Tsuang,Aimee Schantz,Darcy Vavrek,Darcy Vavrek,Eric B. Larson,Walter A. Kukull,Oscar L. Lopez,Douglas Galasko,Eliezer Masliah,Jeffrey Kaye,Randall L. Woltjer,Christopher M. Clark,John Q. Trojanowski,Thomas J. Montine +16 more
TL;DR: Modifications in the published criteria permit a significantly greater number of dementia cases with LRP to be classified and propose that these modified criteria for the categorization of LRP be utilized in patients with a history of dementia.