J
John Q. Trojanowski
Researcher at University of Pennsylvania
Publications - 1538
Citations - 245534
John Q. Trojanowski is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Dementia & Alzheimer's disease. The author has an hindex of 226, co-authored 1467 publications receiving 213948 citations. Previous affiliations of John Q. Trojanowski include Vanderbilt University & University of California, San Francisco.
Papers
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Journal ArticleDOI
MRI and CSF biomarkers in normal, MCI, and AD subjects: Diagnostic discrimination and cognitive correlations
Prashanthi Vemuri,Heather J. Wiste,Stephen D. Weigand,Leslie M. Shaw,John Q. Trojanowski,Michael W. Weiner,David S. Knopman,Ronald C. Petersen,Clifford R. Jack +8 more
TL;DR: Although MRI and CSF provide complementary information, MRI reflects clinically defined disease stage better than the CSF biomarkers tested and the combination of CSF and MRI provides better prediction than either source of data alone.
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Protein transmission in neurodegenerative disease
TL;DR: The evidence for cell-to-cell transmission of pathological proteins in neurodegenerative diseases such as Alzheimer disease and Parkinson disease is summarized, and key questions for future investigation are identified.
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Neurodegenerative tauopathies: human disease and transgenic mouse models.
TL;DR: The discovery of tau gene mutations in FTDP-17 kinand more effective therapies for these disorders is disdreds provides unique opportunities to elucidate the cussed.
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Neuropathology of synuclein aggregates.
TL;DR: Clinicians believe that clarification of the mechanism of synuclein aggregation could augment efforts to develop novel and more effective therapies for many neurodegenerative disorders.
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Amyloid vs FDG-PET in the differential diagnosis of AD and FTLD
Gil D. Rabinovici,Howard J. Rosen,Adi Alkalay,John Kornak,Ansgar J. Furst,Neha Agarwal,Elizabeth C. Mormino,James P. O'Neil,Mustafa Janabi,Anna Karydas,Matthew E. Growdon,J. Y. Jang,Eric J. Huang,S.J. DeArmond,John Q. Trojanowski,Lea T. Grinberg,Maria Luisa Gorno-Tempini,William W. Seeley,Bruce L. Miller,William J. Jagust +19 more
TL;DR: PiB slightly outperformed FDG in patients with known histopathology, and was more sensitive when interpreted qualitatively or quantitatively when scans were classified quantitatively.