J
John Q. Trojanowski
Researcher at University of Pennsylvania
Publications - 1538
Citations - 245534
John Q. Trojanowski is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Dementia & Alzheimer's disease. The author has an hindex of 226, co-authored 1467 publications receiving 213948 citations. Previous affiliations of John Q. Trojanowski include Vanderbilt University & University of California, San Francisco.
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Journal ArticleDOI
Building a roadmap for developing combination therapies for Alzheimer's disease.
Daniel Perry,Reisa A. Sperling,Russell Katz,Donald A. Berry,David M. Dilts,Debra Hanna,Stephen Salloway,John Q. Trojanowski,C. Bountra,Michael Krams,Johan Luthman,Steven G. Potkin,Val Gribkoff,Robert Temple,Yaning Wang,Maria C. Carrillo,Diane Stephenson,Heather M. Snyder,Enchi Liu,Tony Ware,John C. McKew,F. Owen Fields,Lisa J. Bain,Cynthia Bens +23 more
TL;DR: A meeting co-hosted by the Accelerate Cure/Treatments for Alzheimer's Disease Coalition, the Critical Path Institute and the Alzheimer's Association addressed challenges in designing clinical trials to test multiple treatments in combination and outlined a roadmap for making such trials a reality.
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A review and rationale for the use of genetically engineered animals in the study of traumatic brain injury.
Luca Longhi,Kathryn E. Saatman,Ramesh Raghupathi,H. Laurer,Philipp M. Lenzlinger,Peter Riess,Edmund Neugebauer,John Q. Trojanowski,Virginia M.-Y. Lee,M. Sean Grady,David I. Graham,Tracy K. McIntosh +11 more
TL;DR: A compendium of the current literature using genetically engineered mice in studies designed to better understand the posttraumatic inflammatory response, the mechanisms underlying DNA damage, repair, and cell death, and the link between TBI and neurodegenerative diseases is presented.
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Malignant pineocytoma with prominent papillary features
TL;DR: It is reported that papillary features may be a component of pineocytic neoplasms and that they may have prognostic significance and should be distinguished from other benign and malignant papillary neoplasm which also occur in the pineal region.
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The transitional association between β-amyloid pathology and regional brain atrophy
Philip S. Insel,Niklas Mattsson,Niklas Mattsson,Niklas Mattsson,Michael C. Donohue,R. Scott Mackin,Paul S. Aisen,Clifford R. Jack,Leslie M. Shaw,John Q. Trojanowski,Michael W. Weiner,Michael W. Weiner +11 more
TL;DR: To determine the relationship between Aβ and atrophy, the performance of the usual dichotomization of cerebrospinal fluid Aβ was compared to identify subjects as Aβ+ and Aβ− with a trilinear spline model of CSF Aβ.
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Relationship Between CSF Biomarkers of Alzheimer's Disease and Rates of Regional Cortical Thinning in ADNI Data
Duygu Tosun,Norbert Schuff,Norbert Schuff,Leslie M. Shaw,John Q. Trojanowski,Michael W. Weiner,Michael W. Weiner +6 more
TL;DR: The hypothesis that CSF Aβ 1-42 and tau are measures of early AD pathology is supported, and the relationship among CSF biomarkers, ApoE ε4 status, and brain atrophy rates are regionally varying, supporting the view that the genetic predisposition of the brain to amyloid and t Tau mediated pathology is regional and disease stage specific.