J
John Q. Trojanowski
Researcher at University of Pennsylvania
Publications - 1538
Citations - 245534
John Q. Trojanowski is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Dementia & Alzheimer's disease. The author has an hindex of 226, co-authored 1467 publications receiving 213948 citations. Previous affiliations of John Q. Trojanowski include Vanderbilt University & University of California, San Francisco.
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Journal ArticleDOI
Repetitive Mild Brain Trauma Accelerates Aβ Deposition, Lipid Peroxidation, and Cognitive Impairment in a Transgenic Mouse Model of Alzheimer Amyloidosis
Kunihiro Uryu,Helmut L. Laurer,Tracy K. McIntosh,Domenico Praticò,Daniel Martinez,Susan Leight,Virginia M.-Y. Lee,John Q. Trojanowski +7 more
TL;DR: This is the first experimental evidence linking TBI to mechanisms of AD by showing that repetitive TBI accelerates brain Aβ accumulation and oxidative stress, which it is suggested could work synergistically to promote the onset or drive the progression of AD.
Journal ArticleDOI
GWAS of Cerebrospinal Fluid Tau Levels Identifies Risk Variants for Alzheimer’s Disease
Carlos Cruchaga,John S. K. Kauwe,Oscar Harari,Sheng Chih Jin,Yefei Cai,Celeste M. Karch,Bruno A. Benitez,Amanda T. Jeng,Tara Skorupa,David Carrell,Sarah Bertelsen,Matthew H. Bailey,David McKean,Joshua M. Shulman,Philip L. De Jager,Lori B. Chibnik,David A. Bennett,Steve E. Arnold,Denise Harold,Rebecca Sims,Amy Gerrish,Julie Williams,Vivianna M. Van Deerlin,Virginia M.-Y. Lee,Leslie M. Shaw,John Q. Trojanowski,Jonathan L. Haines,Richard Mayeux,Margaret A. Pericak-Vance,Lindsay A. Farrer,Gerard D. Schellenberg,Elaine R. Peskind,Douglas Galasko,Anne M. Fagan,Holtzman David M,John C. Morris,Alison Goate +36 more
TL;DR: In independent data sets, rs9877502 showed a strong association with risk for AD, tangle pathology, and global cognitive decline, illustrating how this endophenotype-based approach can be used to identify new AD risk loci.
Journal ArticleDOI
Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy
Brian C. Kraemer,Bin Zhang,James B. Leverenz,James H. Thomas,John Q. Trojanowski,Gerard D. Schellenberg +5 more
TL;DR: Transgenic model of Frontotemporal dementia with parkinsonism chromosome 17 type is expressed in Caenorhabditis elegans to enable mechanistic dissection of tau-induced neurodegeneration and identification of genes and compounds that inhibit pathological tau formation.
Journal ArticleDOI
Current state of Alzheimer's fluid biomarkers.
José Luis Molinuevo,Scott Ayton,Richard Batrla,Martin M. Bednar,Tobias Bittner,Jeffrey L. Cummings,Anne M. Fagan,Harald Hampel,Michelle M. Mielke,Alvydas Mikulskis,Sid E. O'Bryant,Philip Scheltens,Jeffrey Sevigny,Leslie M. Shaw,Holly Soares,Gary Tong,John Q. Trojanowski,Henrik Zetterberg,Kaj Blennow +18 more
TL;DR: Some of the pathological mechanisms implicated in the sporadic AD are summarized and the data for several established and novel fluid biomarkers associated with each mechanism are highlighted.
Journal ArticleDOI
CSF biomarker variability in the Alzheimer's Association quality control program
Niklas Mattsson,Niklas Mattsson,Ulf Andreasson,Staffan Persson,Maria C. Carrillo,Steven J. Collins,Sonia Chalbot,Neal Cutler,Diane Dufour-Rainfray,Anne M. Fagan,Niels H. H. Heegaard,Ging-Yuek Robin Hsiung,Bradley T. Hyman,Khalid Iqbal,D. Richard Lachno,Alberto Lleó,Piotr Lewczuk,José Luis Molinuevo,Piero Parchi,Axel Regeniter,Robert A. Rissman,Hanna Rosenmann,Giuseppe Sancesario,Johannes Schröder,Leslie M. Shaw,Charlotte E. Teunissen,John Q. Trojanowski,Hugo Vanderstichele,Manu Vandijck,Marcel M. Verbeek,Henrik Zetterberg,Henrik Zetterberg,Kaj Blennow,Stephan A. Käser,Aladro José A. Rojo,Marilyn S. Albert,Daniel Alcolea,Anna Antonell,Hiroyuki Arai,Silvana Archetti,Eva Arkblad,Inês Baldeiras,Ales Bartos,Dev Batish,Aurélie Bedel,Daniele Bentue-Ferrer,Flora Berisha,Sergio Bernardini,Marinus A. Blankenstein,Olivier Bousiges,Michael C. Camuso,Maria Berrocal Carrillo,Tiziana Casoli,Sebastiano Cavallaro,Odete A. da Cruz e Silva,Isabelle Cuvelier,Odile Delaroche,Roy B. Dyer,Sebastiaan Engelborghs,Anne Fogli,Orestes Vicente Forlenza,Nick C. Fox,Giovanni B. Frisoni,Daniela Galimberti,Elisabetta Galloni,Silvana Gritti,Karen H. Gylys,Harald Hampel,Sabine Haustein,Theresa Heath,Michael T. Heneka,Sanna-Kaisa Herukka,David M. Holtzman,Christian Humpel,Takeshi Iwatsubo,Claude Jardel,Mathias Jucker,Elisabeth Kapaki,Daniel Kidd,Péter Klivényi,Ryozo Kuwano,Foudil Lamari,Jean-Louis Laplanche,Jordan Laser,Sylvian Lehmann,Qiao-Xin Li,Walter Maetzler,Catherine Malaplate-Armand,Ralph Martin,Robert Martone,Colin L. Masters,Marc Mercken,Jose Luis Molinuevo,T. J. Montine,William Nowatzke,Markus Otto,Xavier Parent,Lucilla Parnetti,Ronald C. Petersen,Koen Poesen,Isabelle Quadrio,Muriel Quillard,Vara Luis Rello,Zdenek Rohan,Christin Sisowath,Anders Skinningsrud,Holly Soares,Hilkka Soininen,Knudsen Cindy Søndersø,Annette Spreer,Silvia Suardi,C.E. Teunissen,Robert M. Umek,Bianca Van Broeck,Rik Vandenberghe,László Vécsei,M.M. Verbeek,Igor Vostiar,Manfred Windisch +118 more
TL;DR: The cerebrospinal fluid biomarkers amyloid beta 1–42, total tau, and phosphorylated tau are used increasingly for Alzheimer's disease research and patient management, but there are large variations in biomarker measurements among and within laboratories.