J
John Q. Trojanowski
Researcher at University of Pennsylvania
Publications - 1538
Citations - 245534
John Q. Trojanowski is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Dementia & Alzheimer's disease. The author has an hindex of 226, co-authored 1467 publications receiving 213948 citations. Previous affiliations of John Q. Trojanowski include Vanderbilt University & University of California, San Francisco.
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Journal ArticleDOI
Mild head injury increasing the brain's vulnerability to a second concussive impact
Helmut L. Laurer,Florence M. Bareyre,Virginia M.-Y. Lee,John Q. Trojanowski,Luca Longhi,Rachel C. Hoover,Kathryn E. Saatman,Ramesh Raghupathi,Shigeru Hoshino,M. Sean Grady,Tracy K. McIntosh +10 more
TL;DR: The authors suggest that the brain has an increased vulnerability to a second traumatic insult for at least 24 hours following an initial episode of mild brain trauma.
Journal ArticleDOI
Update on the biomarker core of the Alzheimer's Disease Neuroimaging Initiative subjects
John Q. Trojanowski,Hugo Vandeerstichele,Magdalena Korecka,Christopher M. Clark,Paul S. Aisen,Ronald C. Petersen,Kaj Blennow,Holly Soares,Adam J. Simon,Piotr Lewczuk,Robert A. Dean,Eric Siemers,William Z. Potter,Michael W. Weiner,Clifford R. Jack,William J. Jagust,Arthur W. Toga,Virginia M.-Y. Lee,Leslie M. Shaw +18 more
TL;DR: Progress by the Penn Biomarker Core in the Alzheimer's Disease Neuroimaging Initiative (ADNI) toward developing a pathological cerebrospinal fluid and plasma biomarker signature for mild Alzheimer's disease as well as a biomarker profile that predicts conversion of mild cognitive impairment and/or normal control subjects to AD are reviewed.
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Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias.
Gary W. Beecham,Kara Hamilton,Adam C. Naj,Eden R. Martin,Matthew J. Huentelman,Amanda J. Myers,Jason J. Corneveaux,John Hardy,Jean Paul Vonsattel,Steven G. Younkin,David A. Bennett,Philip L. De Jager,Eric B. Larson,Paul K. Crane,M. Ilyas Kamboh,Julia Kofler,Deborah C. Mash,Linda Duque,John R. Gilbert,Harry E. Gwirtsman,Joseph D. Buxbaum,Patricia L. Kramer,Dennis W. Dickson,Lindsay A. Farrer,Matthew P. Frosch,Bernardino Ghetti,Jonathan L. Haines,Bradley T. Hyman,Walter A. Kukull,Richard Mayeux,Margaret A. Pericak-Vance,Julie A. Schneider,John Q. Trojanowski,Eric M. Reiman,Gerard D. Schellenberg,Thomas J. Montine +35 more
TL;DR: A genome-wide association study and analysis of known genetic risk loci for AD dementia using neuropathologic data from 4,914 brain autopsies discovered new genetic associations with specific neuro Pathologic features and aligned known geneticrisk for AD Alzheimer's disease with specific Neuropathologic changes in the largest brain autopsy study of AD and related dementias.
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Comparing positron emission tomography imaging and cerebrospinal fluid measurements of β-amyloid.
Susan M. Landau,Susan M. Landau,Ming Lu,Abhinay D. Joshi,Michael J. Pontecorvo,Mark A. Mintun,John Q. Trojanowski,Leslie M. Shaw,William J. Jagust,William J. Jagust,William J. Jagust +10 more
TL;DR: Analysis of agreement and disagreement between 2 biomarkers of β‐amyloid (Aβ) deposition in normal aging and dementia in a large multicenter study finds no agreement or disagreement between these biomarkers.
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Early vitamin E supplementation in young but not aged mice reduces Aβ levels and amyloid deposition in a transgenic model of Alzheimer’s disease
Syuan Sung,Yuemang Yao,Kunihiro Uryu,Hengxuan Yang,Virginia M.-Y. Lee,John Q. Trojanowski,Domenico Praticò +6 more
TL;DR: The hypothesis that oxidative stress is an important early event in AD pathogenesis, and antioxidant therapy may be beneficial only if given at this stage of the disease process is supported.