J
John Q. Trojanowski
Researcher at University of Pennsylvania
Publications - 1538
Citations - 245534
John Q. Trojanowski is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Dementia & Alzheimer's disease. The author has an hindex of 226, co-authored 1467 publications receiving 213948 citations. Previous affiliations of John Q. Trojanowski include Vanderbilt University & University of California, San Francisco.
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Journal ArticleDOI
Primitive Neuroectodermal Tumors of the Central Nervous System
Lucy Balian Rorke,John Q. Trojanowski,Virginia M.-Y. Lee,Robert A. Zimmerman,Leslie N. Sutton,Jaclyn A. Biegel,Joel W. Goldwein,Roger J. Packer +7 more
TL;DR: Controversial issues relating to the pathobiology and classification of central nervous system primitive neuroectodermal tumors (PNETs) have plagued neuropathologists for more than 70 years despite a growing body of information discrediting these ideas from neuroembryologists, oncologists, neuroscien‐tists and pathologists.
Journal ArticleDOI
Shapes of the Trajectories of 5 Major Biomarkers of Alzheimer Disease
Clifford R. Jack,Prashanthi Vemuri,Heather J. Wiste,Stephen D. Weigand,Timothy G. Lesnick,Val J. Lowe,Kejal Kantarci,Matt A. Bernstein,Matthew L. Senjem,Jeffrey L. Gunter,Bradley F. Boeve,John Q. Trojanowski,Leslie M. Shaw,Paul S. Aisen,Michael W. Weiner,Ronald C. Petersen,David S. Knopman +16 more
TL;DR: Biomarker trajectory shapes by MMSE score were complex and were affected by interactions with age and APOE status, and nonlinearity was found in several baseline effects models.
Journal ArticleDOI
Alzheimer disease tangles share immunological similarities with multiphosphorylation repeats in the two large neurofilament proteins
TL;DR: It is concluded that NFTs share highly specific immunological and structural properties with specific rat heaviest NF sub unit and human middle-sized NF subunit multiphosphorylation repeats.
Journal ArticleDOI
Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture
Ruth Chia,Marya S. Sabir,Sara Bandres-Ciga,Sara Saez-Atienzar,Regina H. Reynolds,Regina H. Reynolds,Regina H. Reynolds,Emil K. Gustavsson,Emil K. Gustavsson,Ronald L. Walton,Samreen Ahmed,Coralie Viollet,Jinhui Ding,Mary B. Makarious,Monica Diez-Fairen,Makayla K. Portley,Zalak Shah,Yevgeniya Abramzon,Yevgeniya Abramzon,Dena G. Hernandez,Cornelis Blauwendraat,David J. Stone,John D. Eicher,Laura Parkkinen,Olaf Ansorge,Lorraine N. Clark,Lawrence S. Honig,Karen Marder,Afina W. Lemstra,Peter St George-Hyslop,Peter St George-Hyslop,Elisabet Londos,Kevin Morgan,Tammaryn Lashley,Thomas T. Warner,Zane Jaunmuktane,Douglas Galasko,Isabel Santana,Pentti J. Tienari,Liisa Myllykangas,Minna Oinas,Nigel J. Cairns,John C. Morris,Glenda M. Halliday,Vivianna M. Van Deerlin,John Q. Trojanowski,Maurizio Grassano,Maurizio Grassano,Andrea Calvo,Gabriele Mora,Antonio Canosa,Gianluca Floris,Ryan C. Bohannan,Francesca Brett,Ziv Gan-Or,Joshua T. Geiger,Anni Moore,Patrick May,Rejko Krüger,Rejko Krüger,David S. Goldstein,Grisel Lopez,Nahid Tayebi,Ellen Sidransky,Lucy Norcliffe-Kaufmann,Jose-Alberto Palma,Horacio Kaufmann,Vikram G. Shakkottai,Matthew H. Perkins,Kathy L. Newell,Thomas Gasser,Claudia Schulte,Francesco Landi,Erika Salvi,Daniele Cusi,Eliezer Masliah,Ronald C. Kim,Chad A. Caraway,Edwin S. Monuki,Maura Brunetti,Ted M. Dawson,Liana S. Rosenthal,Marilyn S. Albert,Olga Pletnikova,Juan C. Troncoso,Margaret E. Flanagan,Qinwen Mao,Eileen H. Bigio,Eloy Rodríguez-Rodríguez,Jon Infante,Carmen Lage,Isabel González-Aramburu,Pascual Sánchez-Juan,Bernardino Ghetti,Julia Keith,Sandra E. Black,Mario Masellis,Ekaterina Rogaeva,Charles Duyckaerts,Alexis Brice,Suzanne Lesage,Georgia Xiromerisiou,Matthew J. Barrett,Bension S. Tilley,Steve M. Gentleman,Giancarlo Logroscino,Geidy E. Serrano,Thomas G. Beach,Ian G. McKeith,Alan J. Thomas,Johannes Attems,Christopher Morris,Laura Palmer,Seth Love,Claire Troakes,Safa Al-Sarraj,Angela Hodges,Dag Aarsland,Dag Aarsland,Gregory Klein,Scott M. Kaiser,Randy Woltjer,Pau Pastor,Lynn M. Bekris,James B. Leverenz,Lilah M. Besser,Amanda B. Kuzma,Alan E. Renton,Alison Goate,David A. Bennett,Clemens R. Scherzer,Huw R. Morris,Raffaele Ferrari,Diego Albani,Stuart Pickering-Brown,Kelley Faber,Walter A. Kukull,Estrella Morenas-Rodríguez,Estrella Morenas-Rodríguez,Alberto Lleó,Juan Fortea,Daniel Alcolea,Jordi Clarimón,Mike A. Nalls,Luigi Ferrucci,Susan M. Resnick,Toshiko Tanaka,Tatiana Foroud,Neill R. Graff-Radford,Zbigniew K. Wszolek,Tanis J. Ferman,Bradley F. Boeve,John Hardy,Eric J. Topol,Ali Torkamani,Andrew B. Singleton,Mina Ryten,Mina Ryten,Dennis W. Dickson,Adriano Chiò,Owen A. Ross,J. Raphael Gibbs,Clifton L. Dalgard,Bryan J. Traynor,Bryan J. Traynor,Bryan J. Traynor,Sonja W. Scholz +166 more
TL;DR: This article performed whole-genome sequencing in large cohorts of Lewy body dementia (LBD) cases and neurologically healthy controls to study the genetic architecture of this understudied form of dementia, and to generate a resource for the scientific community.
Journal ArticleDOI
3D PIB and CSF biomarker associations with hippocampal atrophy in ADNI subjects.
Liana G. Apostolova,Kristy S. Hwang,John P. Andrawis,Amity E. Green,Sona Babakchanian,Jonathan H. Morra,Jeffrey L. Cummings,Arthur W. Toga,John Q. Trojanowski,Leslie M. Shaw,Clifford R. Jack,Ronald C. Petersen,Paul S. Aisen,William J. Jagust,Robert A. Koeppe,Chester A. Mathis,Michael W. Weiner,Paul M. Thompson +17 more
TL;DR: Of the 3 PIB measures the precuneal SUVR showed strongest associations with hippocampal atrophy, and p-tau(181) showed stronger correlation in ApoE4 carriers, while t-Tau showed stronger correlated in ApOE4 noncarriers.