J
John Q. Trojanowski
Researcher at University of Pennsylvania
Publications - 1538
Citations - 245534
John Q. Trojanowski is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Dementia & Alzheimer's disease. The author has an hindex of 226, co-authored 1467 publications receiving 213948 citations. Previous affiliations of John Q. Trojanowski include Vanderbilt University & University of California, San Francisco.
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Journal ArticleDOI
Total and Phosphorylated Tau Protein as Biological Markers of Alzheimer's Disease
Harald Hampel,Kaj Blennow,Leslie M. Shaw,Yvonne C. Hoessler,Henrik Zetterberg,John Q. Trojanowski +5 more
TL;DR: T- and p-tau are considered "core" AD biomarkers that have been successfully validated by controlled large-scale multi-center studies and discussions with regulatory authorities gain momentum defining the role of tau biomarkers for trial designs and how they may be further qualified for surrogate marker status.
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Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies.
Lionel M. Igaz,Linda K. Kwong,Alice Chen-Plotkin,Matthew J. Winton,Travis L. Unger,Yan Xu,Manuela Neumann,John Q. Trojanowski,Virginia M.-Y. Lee +8 more
TL;DR: The hypothesis that the generation of TDP-43 CTFs is an important step in the pathogenesis of FTLD-U and ALS is supported and the specific cleavage site(s) are identified, Arg208, of a pathological TTP purified from FT LD-U brains and expression recapitulates key biochemical features of pathological T DP-43 proteinopathy are shown.
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Altered bile acid profile associates with cognitive impairment in Alzheimer's disease-An emerging role for gut microbiome.
Siamak Mahmoudiandehkordi,Matthias Arnold,Kwangsik Nho,Shahzad Ahmad,Wei Jia,Wei Jia,Guoxiang Xie,Gregory Louie,Alexandra Kueider-Paisley,M. Arthur Moseley,J. Will Thompson,Lisa St John Williams,Jessica D. Tenenbaum,Colette Blach,Rebecca Baillie,Xianlin Han,Sudeepa Bhattacharyya,Jon B. Toledo,Simon Schafferer,Sebastian Klein,Therese Koal,Shannon L. Risacher,Mitchel A. Kling,Alison A. Motsinger-Reif,Daniel M. Rotroff,John Jack,Thomas Hankemeier,David A. Bennett,Philip L. De Jager,John Q. Trojanowski,Leslie M. Shaw,Michael W. Weiner,P. Murali Doraiswamy,Cornelia M. van Duijn,Andrew J. Saykin,Gabi Kastenmüller,Rima Kaddurah-Daouk +36 more
TL;DR: This data indicates that BAs, products of cholesterol metabolism and clearance, are produced in the liver and are further metabolized by gut bacteria and seem dysregulated in Alzheimer's disease (AD).
Journal ArticleDOI
Biomarkers of neurodegeneration for diagnosis and monitoring therapeutics
Leslie M. Shaw,Magdalena Korecka,Christopher M. Clark,Virginia M.-Y. Lee,John Q. Trojanowski +4 more
TL;DR: Progress in the development and validation of biomarkers to improve the diagnosis and treatment of Alzheimer's disease and related disorders is focused on.
Journal ArticleDOI
Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis
Brian C. Kraemer,Brian C. Kraemer,Theresa Schuck,Jeanna M. Wheeler,Jeanna M. Wheeler,Linda C. Robinson,John Q. Trojanowski,Virginia M.-Y. Lee,Gerard D. Schellenberg +8 more
TL;DR: TDP- 43 is essential for viability, and mild reduction in TDP-43 function is sufficient to cause motor deficits without degeneration of motor neurons.