J
John Q. Trojanowski
Researcher at University of Pennsylvania
Publications - 1538
Citations - 245534
John Q. Trojanowski is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Dementia & Alzheimer's disease. The author has an hindex of 226, co-authored 1467 publications receiving 213948 citations. Previous affiliations of John Q. Trojanowski include Vanderbilt University & University of California, San Francisco.
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Journal ArticleDOI
Establishment and characterization of the human medulloblastoma cell line and transplantable xenograft D283 Med.
Henry S. Friedman,Peter C. Burger,S. H. Bigner,John Q. Trojanowski,Carol J. Wikstrand,Edward C. Halperin,Darell D. Bigner +6 more
TL;DR: A new continuous cell line and transplantable xenograft, D283 Med, was derived from the peritoneal implant and ascitic fluid of a child with metastatic medulloblastoma and grew in vitro in suspension culture with spontaneous macroscopic spheroid formation.
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The Spectrum of Mutations in Progranulin: A Collaborative Study Screening 545 Cases of Neurodegeneration
Chang En Yu,Thomas D. Bird,Lynn M. Bekris,Thomas J. Montine,James B. Leverenz,Ellen J. Steinbart,Nichole M. Galloway,Howard Feldman,Randall L. Woltjer,Carol A. Miller,Carol A. Miller,Elisabeth M. Wood,Murray Grossman,Leo McCluskey,Christopher M. Clark,Manuela Neumann,Adrian Danek,Douglas Galasko,Steven E. Arnold,Alice Chen-Plotkin,Anna Karydas,Bruce L. Miller,John Q. Trojanowski,Virginia M.-Y. Lee,Gerard D. Schellenberg,Vivianna M. Van Deerlin +25 more
TL;DR: To delineate the range of clinical presentations associated with GRN mutations and to define pathogenic candidacy of rare GRN variants, a large study of patients with frontotemporal dementia and non-FTD cases identified 58 genetic variants that included 26 previously unknown changes.
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Olfactory epithelium amyloid-beta and paired helical filament-tau pathology in Alzheimer disease.
Steven E. Arnold,Edward B. Lee,Paul J. Moberg,Lauren D. Stutzbach,Hala Kazi,Li-Ying Han,Virginia M.-Y. Lee,John Q. Trojanowski +7 more
TL;DR: Olfactory dysfunction is common in Alzheimer disease (AD) and other neurodegenerative diseases andaired helical filament (PHF)‐tau, α‐synuclein, and amyloid‐β lesions occur early and severely in cerebral regions of the olfactory system, and they have also been observed in Olfactory epithelium (OE).
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Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study
Rita Guerreiro,Rita Guerreiro,Owen A. Ross,Celia Kun-Rodrigues,Dena G. Hernandez,Dena G. Hernandez,Tatiana Orme,John D. Eicher,Claire E. Shepherd,Claire E. Shepherd,Laura Parkkinen,Lee Darwent,Michael G. Heckman,Sonja W. Scholz,Juan C. Troncoso,Olga Pletnikova,Olaf Ansorge,Jordi Clarimón,Alberto Lleó,Estrella Morenas-Rodríguez,Lorraine N. Clark,Lawrence S. Honig,Karen Marder,Afina W. Lemstra,Ekaterina Rogaeva,Peter St George-Hyslop,Peter St George-Hyslop,Elisabet Londos,Henrik Zetterberg,Henrik Zetterberg,Henrik Zetterberg,Imelda Barber,Anne Braae,Kristelle Brown,Kevin Morgan,Claire Troakes,Safa Al-Sarraj,Tammaryn Lashley,Janice L. Holton,Yaroslau Compta,Yaroslau Compta,Vivianna M. Van Deerlin,Geidy E. Serrano,Thomas G. Beach,Suzanne Lesage,Douglas Galasko,Douglas Galasko,Eliezer Masliah,Isabel Santana,Pau Pastor,Pau Pastor,Monica Diez-Fairen,Monica Diez-Fairen,Miquel Aguilar,Miquel Aguilar,Pentti J. Tienari,Liisa Myllykangas,Minna Oinas,Tamas Revesz,Andrew J. Lees,Brad F. Boeve,Ronald C. Petersen,Tanis J. Ferman,Valentina Escott-Price,Neill R. Graff-Radford,Nigel J. Cairns,John C. Morris,Stuart Pickering-Brown,David M. A. Mann,Glenda M. Halliday,Glenda M. Halliday,Glenda M. Halliday,John Hardy,John Q. Trojanowski,Dennis W. Dickson,Andrew B. Singleton,David J. Stone,Jose Bras,Jose Bras +78 more
TL;DR: Despite the small sample size for a genome-wide association study, and acknowledging the potential biases from ascertaining samples from multiple locations, this study presents the most comprehensive and well powered genetic study in dementia with Lewy bodies so far.
Journal ArticleDOI
Distinct cerebral perfusion patterns in FTLD and AD
William T. Hu,Ze Wang,Virginia M.-Y. Lee,John Q. Trojanowski,John A. Detre,Murray Grossman,Murray Grossman +6 more
TL;DR: Doubly dissociated areas of hypoperfusion in FTLD and AD are consistent with areas of significant histopathologic burden in these groups, suggesting ASL is a potentially useful biomarker for distinguishing patients with these neurodegenerative diseases.