Osaka University

About: Osaka University is a education organization based out in Osaka, Japan. It is known for research contribution in the topics: Laser & Catalysis. The organization has 83778 authors who have published 185669 publications receiving 5158122 citations. The organization is also known as: Ōsaka daigaku.

Musashi1: An evolutionally conserved marker for CNS progenitor cells including neural stem cells

Abstract: In situ detection of neural progenitor cells including stem-like cells is essential for studying the basic mechanisms of the generation of cellular diversity in the CNS, upon which therapeutic treatme

On the double object construction

Abstract: This article concerns the structure of a double object construction. It is argued that Larson's arguments for the structure of double objects raise some empirical problems concerning anaphor binding and a semantic relation between the two objects. Next, it is pointed out that the structure corresponding to the present-day double object construction was extremely common in Old English and the structure similar to the dative construction of today began to appear at the beginning of the Middle English period. To accommodate the facts and at the same time to solve the problems with Larson's analysis, it is proposed that the structure of a double object construction is a basic form and the structure of a dative construction is derived from it by passivization within VP.*

Toll-like Receptor 9–Dependent and –Independent Dendritic Cell Activation by Chromatin–Immunoglobulin G Complexes

Abstract: Dendritic cell (DC) activation by nucleic acid–containing immunoglobulin (Ig)G complexes has been implicated in systemic lupus erythematosus (SLE) pathogenesis. However, the mechanisms responsible for activation and subsequent disease induction are not completely understood. Here we show that murine DCs are much more effectively activated by immune complexes that contain IgG bound to chromatin than by immune complexes that contain foreign protein. Activation by these chromatin immune complexes occurs by two distinct pathways. One pathway involves dual engagement of the Fc receptor FcγRIII and Toll-like receptor (TLR)9, whereas the other is TLR9 independent. Furthermore, there is a characteristic cytokine profile elicited by the chromatin immune complexes that distinguishes this response from that of conventional TLR ligands, notably the induction of BAFF and the lack of induction of interleukin 12. The data establish a critical role for self-antigen in DC activation and explain how the innate immune system might drive the adaptive immune response in SLE.