Institution
Osaka University
Education•Osaka, Japan•
About: Osaka University is a education organization based out in Osaka, Japan. It is known for research contribution in the topics: Laser & Catalysis. The organization has 83778 authors who have published 185669 publications receiving 5158122 citations. The organization is also known as: Ōsaka daigaku.
Topics: Laser, Catalysis, Population, Gene, Thin film
Papers published on a yearly basis
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TL;DR: GPC3 is specifically overexpressed in most HCCs and is elevated in the serum of a large proportion of patients with HCC, suggesting that the simultaneous determination of GPC3 and AFP may significantly increase the sensitivity for diagnosis of HCC.
825 citations
TL;DR: This work proposes that there may be a key suppressive mechanism that is shared by every forkhead box p3 (Foxp3)(+) Treg in vivo and in vitro in mice and humans and will help to design effective ways for controlling immune responses by targeting Treg suppressive functions.
Abstract: Regulatory T cells (Tregs), either natural or induced, suppress a variety of physiological and pathological immune responses. One of the key issues for understanding Treg function is to determine how they suppress other lymphocytes at the molecular level in vivo and in vitro. Here we propose that there may be a key suppressive mechanism that is shared by every forkhead box p3 (Foxp3) 1 Treg in vivo and in vitro in mice and humans. When this central mechanism is abrogated, it causes a breach in self-tolerance and immune homeostasis. Other suppressive mechanisms may synergistically operate with this common mechanism depending on the environment and the type of an immune response. Further, Treg-mediated suppression is a multi-step process and impairment or augmentation of each step can alter the ultimate effectiveness of Treg-mediated suppression. These findings will help to design effective ways for controlling immune responses by targeting Treg suppressive functions.
824 citations
TL;DR: It is shown that phosphorylation of the autophagy-adaptor protein p62 markedly increases p62's binding affinity for Keap1, an adaptor of the Cul3-ubiquitin E3 ligase complex responsible for degrading Nrf2, and that inhibitors of the interaction between phosphorylated p62 and Keap 1 have potential as therapeutic agents against human HCC.
824 citations
Flanders Marine Institute1, University of New South Wales2, Australian Museum3, University of Southern Mississippi4, National Oceanography Centre, Southampton5, University of Hasselt6, WorldFish7, American Museum of Natural History8, San Diego State University9, Museum Victoria10, Natural History Museum11, Dowling College12, University of Hamburg13, University of Johannesburg14, James Cook University15, National Museum of Natural History16, National Taiwan Ocean University17, Scripps Institution of Oceanography18, National Oceanic and Atmospheric Administration19, University of Queensland20, University of Sassari21, Université libre de Bruxelles22, Vrije Universiteit Brussel23, Queensland Museum24, University of California, Merced25, Ghent University26, Naturalis27, Howard University28, University of Gothenburg29, Florida Museum of Natural History30, California Academy of Sciences31, Centre for Environment, Fisheries and Aquaculture Science32, Osaka University33, University of Santiago de Compostela34, University of Alaska Anchorage35, University of Málaga36, National Institute of Water and Atmospheric Research37, National University of Ireland, Galway38, University of Alaska Fairbanks39, Spanish National Research Council40, CABI41, University of Siegen42, Massey University43, University of Copenhagen44, Naturhistorisches Museum45, University of Washington46, Museum für Naturkunde47, Woods Hole Oceanographic Institution48, Western Washington University49, University of Bergen50, Nova Southeastern University51, Shirshov Institute of Oceanology52, National University of Singapore53, Shimane University54, Agnes Scott College55, University of the Ryukyus56, University of California, Davis57, Federal University of Paraná58, University of the Basque Country59, University of Veterinary Medicine Hanover60, Royal Belgian Institute of Natural Sciences61, Tel Aviv University62, Swedish Museum of Natural History63, Joint Nature Conservation Committee64, The Evergreen State College65, Estonian University of Life Sciences66, University of Maine67, Virginia Commonwealth University68, Trinity College, Dublin69, University of Auckland70
TL;DR: The first register of the marine species of the world is compiled and it is estimated that between one-third and two-thirds of marine species may be undescribed, and previous estimates of there being well over one million marine species appear highly unlikely.
822 citations
TL;DR: The FAN (fan-out-oriented test generation algorithm) is presented, which is faster and more efficient than the PODEM algorithm reported by Goel and an automatic test generation system composed of the FAN algorithm and the concurrent fault simulation.
Abstract: In order to accelerate an algorithm for test generation, it is necessary to reduce the number of backtracks in the algorithm and to shorten the process time between backtracks. In this paper, we consider several techniques to accelerate test generation and present a new test generation algorithm called FAN (fan-out-oriented test generation algorithm). It is shown that the FAN algorithm is faster and more efficient than the PODEM algorithm reported by Goel. We also present an automatic test generation system composed of the FAN algorithm and the concurrent fault simulation. Experimental results on large combinational circuits of up to 3000 gates demonstrate that the system performs test generation very fast and effectively.
821 citations
Authors
Showing all 84130 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Shizuo Akira | 261 | 1308 | 320561 |
| Thomas C. Südhof | 191 | 653 | 118007 |
| Tadamitsu Kishimoto | 181 | 1067 | 130860 |
| Yusuke Nakamura | 179 | 2076 | 160313 |
| H. S. Chen | 179 | 2401 | 178529 |
| Hyun-Chul Kim | 176 | 4076 | 183227 |
| Masayuki Yamamoto | 171 | 1576 | 123028 |
| Kenji Kangawa | 153 | 1117 | 110059 |
| Jongmin Lee | 150 | 2257 | 134772 |
| Yoshio Bando | 147 | 1234 | 80883 |
| Takeo Kanade | 147 | 799 | 103237 |
| Olaf Reimer | 144 | 716 | 74359 |
| Yuji Matsuzawa | 143 | 836 | 116711 |
| Kim Nasmyth | 142 | 294 | 59231 |
| Tasuku Honjo | 141 | 712 | 88428 |