Institution
Osaka University
Education•Osaka, Japan•
About: Osaka University is a education organization based out in Osaka, Japan. It is known for research contribution in the topics: Laser & Catalysis. The organization has 83778 authors who have published 185669 publications receiving 5158122 citations. The organization is also known as: Ōsaka daigaku.
Topics: Laser, Catalysis, Population, Gene, Thin film
Papers published on a yearly basis
Papers
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TL;DR: The results suggest that transcription of the IFN and IFN-inducible genes is regulated by two similar trans-acting factors that apparently compete for the same cis-acting recognition sequences, but which have opposite effects.
909 citations
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Massachusetts Institute of Technology1, Goddard Space Flight Center2, Kyoto University3, Nagoya University4, University of Tokyo5, Osaka University6, Ehime University7, University of Cambridge8, Hiroshima University9, Carnegie Mellon University10, Max Planck Society11, University of Miyazaki12, Franklin W. Olin College of Engineering13, Rutgers University14, Tokyo Metropolitan University15, Kobe University16, Stanford University17, Tokyo Institute of Technology18, Rikkyo University19, Kogakuin University20, Tokyo University of Science21, University of Wisconsin-Madison22, Kanazawa University23, Nihon University24, Pennsylvania State University25, European Space Research and Technology Centre26, Yale University27, Saitama University28, Chuo University29, University of Leicester30, Nihon Fukushi University31, Aoyama Gakuin University32, Iwate University33
TL;DR: In this paper, the authors summarized the spacecraft, in-orbit performance, operations, and data processing that are related to observations of the Suzaku X-ray observatory, including high-sensitivity wide-band Xray spectroscopy.
Abstract: High-sensitivity wide-band X-ray spectroscopy is the key feature of the Suzaku X-ray observatory, launched on 2005 July 10. This paper summarizes the spacecraft, in-orbit performance, operations, and data processing that are related to observations. The scientific instruments, the high-throughput X-ray telescopes, X-ray CCD cameras, non-imaging hard X-ray detector are also described.
908 citations
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TL;DR: Recent insights into the signaling pathways initiated by TLR and RLR are reviewed and their roles in innate and adaptive immune responses are reviewed.
Abstract: Toll-like receptors (TLRs) and RIG-I-like receptors (RLRs) constitute distinct families of pattern-recognition receptors that sense nucleic acids derived from viruses and trigger antiviral innate immune responses. TLR3, TLR7, and TLR9 are membrane proteins localized to the endosome that recognize viral double-stranded RNA, single-stranded RNA, and DNA, respectively, while RLRs, including RIG-I, Mda5, and LGP2, are cytoplasmic proteins that recognize viral RNA. Upon recognition of these nucleic acid species, TLRs and RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways culminating in activation of NF-κB, MAP kinases, and IRFs that control the transcription of genes encoding type I interferon and other inflammatory cytokines, which are important for eliminating viruses. Here, we review recent insights into the signaling pathways initiated by TLR and RLR and their roles in innate and adaptive immune responses.
907 citations
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Fukuoka University1, Kindai University2, Teikyo University3, Nagoya Gakuin University4, International University of Health and Welfare5, Jichi Medical University6, Dokkyo Medical University7, Mie University8, Tohoku University9, Kurume University10, Osaka University11, Tokyo Medical University12, Kawasaki Medical School13, Saitama Medical University14, University of Miyazaki15, Kyushu University16, Ehime University17, National Defense Medical College18, Shiga University of Medical Science19, Kumamoto University20, Kansai University of Welfare Sciences21, University of the Ryukyus22, Sapporo Medical University23, Oita University24, Yokohama City University25, Yokohama City University Medical Center26
TL;DR: The story of the life and times of Toshihiko Umemura and his family in the years leading up to and including his death.
Abstract: Satoshi Umemura ● Hisatomi Arima ● Shuji Arima ● Kei Asayama ● Yasuaki Dohi ● Yoshitaka Hirooka ● Takeshi Horio ● Satoshi Hoshide ● Shunya Ikeda ● Toshihiko Ishimitsu ● Masaaki Ito ● Sadayoshi Ito ● Yoshio Iwashima ● Hisashi Kai ● Kei Kamide ● Yoshihiko Kanno ● Naoki Kashihara ● Yuhei Kawano ● Toru Kikuchi ● Kazuo Kitamura ● Takanari Kitazono ● Katsuhiko Kohara ● Masataka Kudo ● Hiroo Kumagai ● Kiyoshi Matsumura ● Hideo Matsuura ● Katsuyuki Miura ● Masashi Mukoyama ● Satoko Nakamura ● Takayoshi Ohkubo ● Yusuke Ohya ● Takafumi Okura ● Hiromi Rakugi ● Shigeyuki Saitoh ● Hirotaka Shibata ● Tatsuo Shimosawa ● Hiromichi Suzuki ● Shori Takahashi ● Kouichi Tamura ● Hirofumi Tomiyama ● Takuya Tsuchihashi ● Shinichiro Ueda ● Yoshinari Uehara ● Hidenori Urata ● Nobuhito Hirawa
903 citations
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TL;DR: Data suggest that an enhanced expression of the PAI–1 gene in visceral fat may increase plasma levels and may have a role in the development of vascular disease in visceral obesity.
Abstract: The presence of obesity increases the risk of thrombotic vascular diseases. The role of fat accumulation and its effect on plasminogen activator inhibitor-1 (PAI-1) levels was investigated in humans and animals. Plasma PAI-1 levels were closely correlated with visceral fat area but not with subcutaneous fat area in human subjects. PAI-1 mRNA was detected in both types of fat tissue in obese rats but increased only in visceral fat during the development of obesity. These data suggest that an enhanced expression of the PAI-1 gene in visceral fat may increase plasma levels and may have a role in the development of vascular disease in visceral obesity.
902 citations
Authors
Showing all 84130 results
Name | H-index | Papers | Citations |
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Shizuo Akira | 261 | 1308 | 320561 |
Thomas C. Südhof | 191 | 653 | 118007 |
Tadamitsu Kishimoto | 181 | 1067 | 130860 |
Yusuke Nakamura | 179 | 2076 | 160313 |
H. S. Chen | 179 | 2401 | 178529 |
Hyun-Chul Kim | 176 | 4076 | 183227 |
Masayuki Yamamoto | 171 | 1576 | 123028 |
Kenji Kangawa | 153 | 1117 | 110059 |
Jongmin Lee | 150 | 2257 | 134772 |
Yoshio Bando | 147 | 1234 | 80883 |
Takeo Kanade | 147 | 799 | 103237 |
Olaf Reimer | 144 | 716 | 74359 |
Yuji Matsuzawa | 143 | 836 | 116711 |
Kim Nasmyth | 142 | 294 | 59231 |
Tasuku Honjo | 141 | 712 | 88428 |