Institution
Osaka University
Education•Osaka, Japan•
About: Osaka University is a education organization based out in Osaka, Japan. It is known for research contribution in the topics: Laser & Catalysis. The organization has 83778 authors who have published 185669 publications receiving 5158122 citations. The organization is also known as: Ōsaka daigaku.
Topics: Laser, Catalysis, Population, Gene, Thin film
Papers published on a yearly basis
Papers
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TL;DR: Depletion of FOXP3hi Treg cells from tumor tissues, which would augment antitumor immunity, could thus be used as an effective treatment strategy for CRCs and other cancers, whereas strategies that locally increase the population ofFOXP3lo non-Treg cells could be used to suppress or prevent tumor formation.
Abstract: Shimon Sakaguchi and colleagues report that FOXP3+CD4+ T cell subsets differ functionally and are associated with distinct prognoses for individuals with colorectal cancer.
579 citations
TL;DR: The wearable artificial endocrine pancreas, incorporating the needle-type glucose sensor, a computer calculating infusion rates of insulin, glucagon, or both, and infusion pumps, was tested in pancreatectomised dogs and produced perfect control of blood glucose for up to 7 days.
578 citations
TL;DR: Genome-wide analysis of postnatal NSCs indicates that Dnmt3a occupies and methylates intergenic regions and gene bodies flanking proximal promoters of a large cohort of transcriptionally permissive genes, many of which encode regulators of neurogenesis and may be used for maintaining active chromatin states of genes critical for development.
Abstract: DNA methylation at proximal promoters facilitates lineage restriction by silencing cell type-specific genes. However, euchromatic DNA methylation frequently occurs in regions outside promoters. The functions of such nonproximal promoter DNA methylation are unclear. Here we show that the de novo DNA methyltransferase Dnmt3a is expressed in postnatal neural stem cells (NSCs) and is required for neurogenesis. Genome-wide analysis of postnatal NSCs indicates that Dnmt3a occupies and methylates intergenic regions and gene bodies flanking proximal promoters of a large cohort of transcriptionally permissive genes, many of which encode regulators of neurogenesis. Surprisingly, Dnmt3a-dependent nonproximal promoter methylation promotes expression of these neurogenic genes by functionally antagonizing Polycomb repression. Thus, nonpromoter DNA methylation by Dnmt3a may be used for maintaining active chromatin states of genes critical for development.
577 citations
TL;DR: These adipose tissue–derived cells demonstrated potential asAngiogenic cell therapy for ischemic disease, which appears to be mainly achieved by their ability to secrete angiogenic growth factors.
Abstract: Objective— The delivery of autologous progenitor cells into ischemic tissue of patients is emerging as a novel therapeutic option. Here, we report the potential impact of cultured adipose tissue–de...
577 citations
TL;DR: The innate immune system is an evolutionarily conserved system of defense against microbial infections and Toll-like receptors activate common and unique transcription factors through different signaling pathways to drive specific biological responses against microorganisms.
575 citations
Authors
Showing all 84130 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Shizuo Akira | 261 | 1308 | 320561 |
| Thomas C. Südhof | 191 | 653 | 118007 |
| Tadamitsu Kishimoto | 181 | 1067 | 130860 |
| Yusuke Nakamura | 179 | 2076 | 160313 |
| H. S. Chen | 179 | 2401 | 178529 |
| Hyun-Chul Kim | 176 | 4076 | 183227 |
| Masayuki Yamamoto | 171 | 1576 | 123028 |
| Kenji Kangawa | 153 | 1117 | 110059 |
| Jongmin Lee | 150 | 2257 | 134772 |
| Yoshio Bando | 147 | 1234 | 80883 |
| Takeo Kanade | 147 | 799 | 103237 |
| Olaf Reimer | 144 | 716 | 74359 |
| Yuji Matsuzawa | 143 | 836 | 116711 |
| Kim Nasmyth | 142 | 294 | 59231 |
| Tasuku Honjo | 141 | 712 | 88428 |