Osaka University

About: Osaka University is a education organization based out in Osaka, Japan. It is known for research contribution in the topics: Laser & Catalysis. The organization has 83778 authors who have published 185669 publications receiving 5158122 citations. The organization is also known as: Ōsaka daigaku.

Expression of E-cadherin cell adhesion molecules in human breast cancer tissues and its relationship to metastasis

Abstract: E-cadherin (E-cad) is a subclass of the cadherin family that plays a major role in maintenance of intercellular junctions in epithelial tissues In order to explore the correlation between the expression of E-cad and cancer invasion and metastasis in vivo, we performed an immunohistochemical examination for E-cad expression in 120 patients with breast cancer using our specific anti-E-cad monoclonal antibody In noncancerous epithelial cells, E-cad was strongly expressed on cell-cell boundaries, whereas various staining patterns were observed in tumors Of these 120 tumors, 56 (47%) showed Pr type expression of E-cad, and 64 (53%) showed Rd type or negative expression We found significant correlations between E-cad expression and clinicopathological features The frequency of Rd type was significantly higher in invasive ductal carcinomas (58%, 56 of 97) and poorly differentiated carcinomas (84%, 21 of 25) than in noninvasive and well-differentiated carcinomas Furthermore, a high frequency of Rd type was detected in the following advanced tumors: T3,4 tumors, 71% (22 of 31); tumors with extensive lymph node metastasis, 74% (29 of 39); and tumors with distant metastasis, 86% (19 of 22) These values were significantly higher compared with their counterparts The expression of epidermal growth factor receptor tended to be positive in E-cad-positive tumors However, no significant relationship was seen among E-cad expression, menopausal status, hormone receptor status, and DNA ploidy pattern These results suggest that the reduction of E-cad expression may play an important role in invasion and metastasis of human breast cancer

Crystal faces of rutile and anatase TiO2 particles and their roles in photocatalytic reactions

Abstract: A titanium dioxide powder consisting of 1 μm size rutile and anatase particles was obtained, on which developed crystal faces were observed by a scanning electron microscope. From electron diffraction analyses, it was found that the rutile particles exposed {011} and {110} crystal faces, and the anatase particles exposed {001} and {011} faces. This powder showed high activity for some photocatalytic reactions, including oxidation of water. After photocatalytic oxidation of water on the powder using hexachloroplatinate(IV) ions as the electron acceptors, Pt deposits were observed mostly on the rutile particles, especially on the {110} face. When 2-propanol was added to the solution, Pt was deposited on both the anatase and rutile particles. Using the thus prepared Pt-deposited TiO2 powder, Pb2+ ions were photocatalytically oxidized into PbO2. After this reaction, PbO2 deposits were seen on the {011} face of the rutile particles. On the anatase particles, PbO2 deposits were observed in a larger amount on the {001} face than on the {011} face. These results indicate that the crystal faces help in the separation of electrons and holes, and that this effect is stronger for the rutile particles than for the anatase particles.