Temple University

About: Temple University is a education organization based out in Philadelphia, Pennsylvania, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 32154 authors who have published 64375 publications receiving 2219828 citations.

Adolescent Development in Interpersonal Context

Abstract: This chapter addresses the psychological processes associated with attaining autonomy and forming interdependent relationships with others during the second decade of life. We divide the chapter into six major sections. First, we provide an overview of the defining features of adolescence, including biological and cognitive maturation and changes in societal expectations of adolescent individuals. Second, we characterize influential conceptual perspectives on adolescence. Third, we outline the expanding social networks of adolescents and the nature and significance of interpersonal relationships with family members, friends, and romantic interests. Fourth, we describe the impact of social contexts, such as neighborhoods, schools, the workplace, and leisure settings. Fifth, we consider key adolescent developmental tasks of achieving both a sense of independence and satisfying and effective interdependent relationships with others. Finally, we consider how this contemporary approach illuminates growth and change during adolescence, as well as differences between childhood, adolescence, and adulthood. Keywords: adolescence; independence; interdependence; interpersonal development

Dual action 2',5'-oligoadenylate antiviral derivatives and uses thereof

Abstract: Viral infection is inhibited in mammals by administration of metabolically stable, non-toxic 2',5'-oligoadenylate (2-5A) de-rivatives that have a dual therapeutic effect. The compounds activate the intracellular latent 2-5A dependent endoribonuclease RNase L and also inhibit the action of viral DNA polymerases. Conjugates of the 2-5A derivatives for therapeutic delivery are also described:

The interpersonal theory of suicide: A systematic review and meta-analysis of a decade of cross-national research.

Abstract: Over the past decade, the interpersonal theory of suicide has contributed to substantial advances in the scientific and clinical understanding of suicide and related conditions. The interpersonal theory of suicide posits that suicidal desire emerges when individuals experience intractable feelings of perceived burdensomeness and thwarted belongingness and near-lethal or lethal suicidal behavior occurs in the presence of suicidal desire and capability for suicide. A growing number of studies have tested these posited pathways in various samples; however, these findings have yet to be evaluated meta-analytically. This paper aimed to (a) conduct a systematic review of the unpublished and published, peer-reviewed literature examining the relationship between interpersonal theory constructs and suicidal thoughts and behaviors, (b) conduct meta-analyses testing the interpersonal theory hypotheses, and (c) evaluate the influence of various moderators on these relationships. Four electronic bibliographic databases were searched through the end of March, 2016: PubMed, Medline, PsycINFO, and Web of Science. Hypothesis-driven meta-analyses using random effects models were conducted using 122 distinct unpublished and published samples. Findings supported the interpersonal theory: the interaction between thwarted belongingness and perceived burdensomeness was significantly associated with suicidal ideation; and the interaction between thwarted belongingness, perceived burdensomeness, and capability for suicide was significantly related to a greater number of prior suicide attempts. However, effect sizes for these interactions were modest. Alternative configurations of theory variables were similarly useful for predicting suicide risk as theory-consistent pathways. We conclude with limitations and recommendations for the interpersonal theory as a framework for understanding the suicidal spectrum. (PsycINFO Database Record