Temple University

About: Temple University is a education organization based out in Philadelphia, Pennsylvania, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 32154 authors who have published 64375 publications receiving 2219828 citations.

STAT proteins: from normal control of cellular events to tumorigenesis.

Abstract: Signal transducers and activators of transcription (STAT) proteins comprise a family of transcription factors latent in the cytoplasm that participate in normal cellular events, such as differentiation, proliferation, cell survival, apoptosis, and angiogenesis following cytokine, growth factor, and hormone signaling. STATs are activated by tyrosine phosphorylation, which is normally a transient and tightly regulates process. Nevertheless, several constitutively activated STATs have been observed in a wide number of human cancer cell lines and primary tumors, including blood malignancies and solid neoplasias. STATs can be divided into two groups according to their specific functions. One is made up of STAT2, STAT4, and STAT6, which are activated by a small number of cytokines and play a distinct role in the development of T-cells and in IFNgamma signaling. The other group includes STAT1, STAT3, and STAT5, activated in different tissues by means of a series of ligands and involved in IFN signaling, development of the mammary gland, response to GH, and embriogenesis. This latter group of STATS plays an important role in controlling cell-cycle progression and apoptosis and thus contributes to oncogenesis. Although an increased expression of STAT1 has been observed in many human neoplasias, this molecule can be considered a potential tumor suppressor, since it plays an important role in growth arrest and in promoting apoptosis. On the other hand, STAT3 and 5 are considered as oncogenes, since they bring about the activation of cyclin D1, c-Myc, and bcl-xl expression, and are involved in promoting cell-cycle progression, cellular transformation, and in preventing apoptosis.

The impact of knowledge coordination on virtual team performance over time

Abstract: As the role of virtual teams in organizations becomes increasingly important, it is crucial that companies identify and leverage team members' knowledge. Yet, little is known of how virtual team members come to recognize one another's knowledge, trust one another's expertise, and coordinate their knowledge effectively. In this study, we develop a model of how three behavioral dimensions associated with transactive memory systems (TMS) in virtual teams-expertise location, task-knowledge coordination, and cognition-based trust-and their impacts on team performance change over time. Drawing on the data from a study that involves 38 virtual teams of MBA students performing a complex web-based business simulation game over an 8-week period, we found that in the early stage of the project, the frequency and volume of task-oriented communications among team members played an important role in forming expertise location and cognition-based trust. Once TMS were established, however, task-oriented communication became less important. Instead, toward the end of the project, task-knowledge coordination emerges as a key construct that influences team performance, mediating the impact of all other constructs. Our study demonstrates that TMS can be formed even in virtual team environments where interactions take place solely through electronic media, although they take a relatively long time to develop. Furthermore, our findings show that, once developed, TMS become essential to performing tasks effectively in virtual teams.

Interacting effects of information and coping style in adapting to gynecologic stress: should the doctor tell all?

Abstract: This study explored the interacting effects of personal dispositions and situational conditions on the stress response. Forty gynecologic patients about to undergo a diagnostic procedure (colposcopy) were divided into information seekers (monitors) and information avoiders (blunters). Half in each group were exposed to voluminous preparatory information, and half to the usual low level of information. Subjective, physiological, and behavioral measures of arousal and discomfort were obtained before, during, and after the procedure. Overall, low-information patients expressed less subjective arousal than high-information patients, and blunters showed less subjective and behavioral arousal than monitors. In addition, patients' level of psychophysiological arousal was lower when the level of preparatory information was consistent with their coping style; that is, blunters were less aroused with low information and monitors were less aroused with high information. Further evidence was gained for the utility and validity of a new scale for identifying monitors and blunters.

The impact of information technology and transactive memory systems on knowledge sharing, application, and team performance: a field study

Abstract: In contemporary knowledge-based organizations, teams often play an essential role in leveraging knowledge resources. Organizations make significant investments in information technology to support knowledge management practices in teams. At the same time, recent studies show that the transactive memory system (TMS)-the specialized division of cognitive labor among team members that relates to the encoding, storage, and retrieval of knowledge-is an important factor that affects a team's performance. Yet little is known of how IT support for knowledge management practices in organizations affects the development of TMS. Furthermore, the precise role of TMS on knowledge sharing and knowledge application, which in turn influences team performance, has not been fully explored. In order to close this gap in the literature, we conducted a field study that involved 139 on-going teams of 743 individuals from two major firms in South Korea. Our results show that IT support in organizations has a positive impact on the development of TMS in teams, and that both TMS and IT support have a positive impact on knowledge sharing and knowledge application. Furthermore, we found that knowledge sharing has a positive impact on knowledge application, which in turn has a direct impact on team performance. However, contrary to our expectation, knowledge sharing does not have a direct impact on team performance and its impact on team performance was fully mediated by knowledge application. Our research shows that organizations can improve team members' meta-knowledge of who knows what through the careful investment in information technology. Finally, our results show that sharing knowledge alone is not enough. Organizations must ensure that shared knowledge is in fact applied in order to improve team performance.