Institution
Temple University
Education•Philadelphia, Pennsylvania, United States•
About: Temple University is a education organization based out in Philadelphia, Pennsylvania, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 32154 authors who have published 64375 publications receiving 2219828 citations.
Topics: Population, Poison control, Anxiety, Context (language use), Medicine
Papers published on a yearly basis
Papers
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Teikyo University1, Washington University in St. Louis2, Mayo Clinic3, Yokohama City University4, Oita University5, Keio University6, Temple University7, Toho University8, Seoul National University Bundang Hospital9, Memorial Hospital of South Bend10, Kyushu University11, Tokyo Medical University12, Lilavati Hospital and Research Centre13, University of Edinburgh14, Fujita Health University15, University of Buenos Aires16, International University of Health and Welfare17, Rush University Medical Center18, National University of Singapore19, University of Occupational and Environmental Health Japan20, Yonsei University21, Konyang University22, University of Cape Town23, Huazhong University of Science and Technology24
TL;DR: In the Tokyo Guidelines 2018 (TG18) as discussed by the authors, the authors proposed a flowchart for the treatment of acute cholecystitis (AC) in advanced centers with specialized surgeons experienced in this procedure.
Abstract: We propose a new flowchart for the treatment of acute cholecystitis (AC) in the Tokyo Guidelines 2018 (TG18). Grade III AC was not indicated for straightforward laparoscopic cholecystectomy (Lap-C). Following analysis of subsequent clinical investigations and drawing on Big Data in particular, TG18 proposes that some Grade III AC can be treated by Lap-C when performed at advanced centers with specialized surgeons experienced in this procedure and for patients that satisfy certain strict criteria. For Grade I, TG18 recommends early Lap-C if the patients meet the criteria of Charlson comorbidity index (CCI) ≤5 and American Society of Anesthesiologists physical status classification (ASA-PS) ≤2. For Grade II AC, if patients meet the criteria of CCI ≤5 and ASA-PS ≤2, TG18 recommends early Lap-C performed by experienced surgeons; and if not, after medical treatment and/or gallbladder drainage, Lap-C would be indicated. TG18 proposes that Lap-C is indicated in Grade III patients with strict criteria. These are that the patients have favorable organ system failure, and negative predictive factors, who meet the criteria of CCI ≤3 and ASA-PS ≤2 and who are being treated at an advanced center (where experienced surgeons practice). If the patient is not considered suitable for early surgery, TG18 recommends early/urgent biliary drainage followed by delayed Lap-C once the patient's overall condition has improved. Free full articles and mobile app of TG18 are available at: http://www.jshbps.jp/modules/en/index.php?content_id=47. Related clinical questions and references are also included.
422 citations
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TL;DR: In this article, the authors discuss differences in 100 families with and without a handicapped child with respect to three types of stress (individual, marital, and parenting) and three structural characteristics of their social support networks (size, density, and boundary density).
Abstract: This paper discusses differences in 100 families with and without a handicapped child with respect to three types of stress (individual, marital, and parenting) and three structural characteristics of their social support networks (size, density, and boundary density). Generally, higher levels of stress and distinct network structures were found for the families with handicapped children. Despite the presence of high levels of stress, the families were found to have successful coping strategies. The results are discussed in terms of recognizing family strengths, and incorporating existing adaptational patterns in clinical interventions.
421 citations
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TL;DR: Findings suggest the existence of a second delta-like analgesic system in mice that does not develop analgesic tolerance to morphine, genetically demonstrating a central role for DOR-1 in this process.
421 citations
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TL;DR: Subjects with moderate to severe COPD did not benefit from treatment with infliximab and the impact of inflIXimab on malignancy risk in patients with COPD needs to be further elucidated.
Abstract: Rationale: Chronic obstructive pulmonary disease (COPD) is a progressive, smoking-related, inflammatory lung disease in which tumor necrosis factor-α is overexpressed and has been suggested to play a pathogenic role.Objectives: To determine if infliximab, an anti–TNF-α antibody, results in clinical benefit and has an acceptable safety profile in patients with moderate to severe COPD.Methods: In a multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-finding study, subjects with moderate to severe COPD received infliximab (3 mg/kg [n = 78] or 5 mg/kg [n = 79]) or placebo (n = 77) at Weeks 0, 2, 6, 12, 18, and 24. Efficacy, health status, and safety were assessed through Week 44.Measurements and Main Results: Infliximab was generally well tolerated, but showed no treatment benefit as measured by the primary endpoint, Chronic Respiratory Questionnaire total score. Similarly, there was no change in secondary measures, including prebronchodilator FEV1, 6-min walk distance, SF-36 physi...
421 citations
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TL;DR: These findings represent the first demonstration of UPR activation in subcutaneous adipose tissue of obese human subjects and may be a link between obesity, insulin resistance, and inflammation.
Abstract: OBJECTIVE—To examine fat biopsy samples from lean insulin-sensitive and obese insulin-resistant nondiabetic individuals for evidence of endoplasmic reticulum (ER) stress.
RESEARCH DESIGN AND METHODS—Subcutaneous fat biopsies were obtained from the upper thighs of six lean and six obese nondiabetic subjects. Fat homogenates were used for proteomic (two-dimensional gel and MALDI-TOF/TOF), Western blot, and RT-PCR analysis.
RESULTS—Proteomic analysis revealed 19 differentially upregulated proteins in fat of obese subjects. Three of these proteins were the ER stress–related unfolded protein response (UPR) proteins calreticulin, protein disulfide-isomerase A3, and glutathione-S-transferase P. Western blotting revealed upregulation of several other UPR stress–related proteins, including calnexin, a membrane-bound chaperone, and phospho c-jun NH2-terminal kinase (JNK)-1, a downstream effector protein of ER stress. RT-PCR analysis revealed upregulation of the spliced form of X-box binding protein-1s, a potent transcription factor and part of the proximal ER stress sensor inositol-requiring enzyme-1 pathway.
CONCLUSIONS—These findings represent the first demonstration of UPR activation in subcutaneous adipose tissue of obese human subjects. As JNK can inhibit insulin action and activate proinflammatory pathways, ER stress activation of JNK may be a link between obesity, insulin resistance, and inflammation.
421 citations
Authors
Showing all 32360 results
Name | H-index | Papers | Citations |
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Robert J. Lefkowitz | 214 | 860 | 147995 |
Rakesh K. Jain | 200 | 1467 | 177727 |
Virginia M.-Y. Lee | 194 | 993 | 148820 |
Yury Gogotsi | 171 | 956 | 144520 |
Timothy A. Springer | 167 | 669 | 122421 |
Ralph A. DeFronzo | 160 | 759 | 132993 |
James J. Collins | 151 | 669 | 89476 |
Robert J. Glynn | 146 | 748 | 88387 |
Edward G. Lakatta | 146 | 858 | 88637 |
Steven Williams | 144 | 1375 | 86712 |
Peter Buchholz | 143 | 1181 | 92101 |
David Goldstein | 141 | 1301 | 101955 |
Scott D. Solomon | 137 | 1145 | 103041 |
Donald B. Rubin | 132 | 515 | 262632 |
Jeffery D. Molkentin | 131 | 482 | 61594 |