Temple University

About: Temple University is a education organization based out in Philadelphia, Pennsylvania, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 32154 authors who have published 64375 publications receiving 2219828 citations.

Incremental Local Outlier Detection for Data Streams

Abstract: Outlier detection has recently become an important problem in many industrial and financial applications. This problem is further complicated by the fact that in many cases, outliers have to be detected from data streams that arrive at an enormous pace. In this paper, an incremental LOF (local outlier factor) algorithm, appropriate for detecting outliers in data streams, is proposed. The proposed incremental LOF algorithm provides equivalent detection performance as the iterated static LOF algorithm (applied after insertion of each data record), while requiring significantly less computational time. In addition, the incremental LOF algorithm also dynamically updates the profiles of data points. This is a very important property, since data profiles may change over time. The paper provides theoretical evidence that insertion of a new data point as well as deletion of an old data point influence only limited number of their closest neighbors and thus the number of updates per such insertion/deletion does not depend on the total number of points TV in the data set. Our experiments performed on several simulated and real life data sets have demonstrated that the proposed incremental LOF algorithm is computationally efficient, while at the same time very successful in detecting outliers and changes of distributional behavior in various data stream applications

G Protein regulation of MAPK networks

Abstract: G proteins provide signal-coupling mechanisms to heptahelical cell surface receptors and are critically involved in the regulation of different mitogen-activated protein kinase (MAPK) networks. The four classes of G proteins, defined by the G(s), G(i), G(q) and G(12) families, regulate ERK1/2, JNK, p38MAPK, ERK5 and ERK6 modules by different mechanisms. The alpha- as well as betagamma-subunits are involved in the regulation of these MAPK modules in a context-specific manner. While the alpha- and betagamma-subunits primarily regulate the MAPK pathways via their respective effector-mediated signaling pathways, recent studies have unraveled several novel signaling intermediates including receptor tyrosine kinases and small GTPases through which these G-protein subunits positively as well as negatively regulate specific MAPK modules. Multiple mechanisms together with specific scaffold proteins that can link G-protein-coupled receptors or G proteins to distinct MAPK modules contribute to the context-specific and spatio-temporal regulation of mitogen-activated protein signaling networks by G proteins.