Temple University

About: Temple University is a education organization based out in Philadelphia, Pennsylvania, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 32154 authors who have published 64375 publications receiving 2219828 citations.

Selective inhibition of leukemia cell proliferation by BCR-ABL antisense oligodeoxynucleotides

Abstract: To determine the role of the BCR-ABL gene in the proliferation of blast cells of patients with chronic myelogenous leukemia, leukemia blast cells were exposed to synthetic 18-mer oligodeoxynucleotides complementary to two identified BCR-ABL junctions. Leukemia colony formation was suppressed, whereas granulocyte-macrophage colony formation from normal marrow progenitors was unaffected. When equal proportions of normal marrow progenitors and blast cells were mixed, exposed to the oligodeoxynucleotides, and assayed for residual colony formation, the majority of residual cells were normal. These findings demonstrate the requirement for a functional BCR-ABL gene in maintaining the leukemic phenotype and the feasibility of gene-targeted selective killing of neoplastic cells.

Consolidation and efficiency in the US life insurance industry

Abstract: This paper examines the relationship between mergers and acquisitions, efficiency, and scale economies in the US life insurance industry. We estimate cost and revenue efficiency over the period 1988–1995 using data envelopment analysis (DEA). The Malmquist methodology is used to measure changes in efficiency over time. We find that acquired firms achieve greater efficiency gains than firms that have not been involved in mergers or acquisitions. Firms operating with non-decreasing returns to scale (NDRS) and financially vulnerable firms are more likely to be acquisition targets. Overall, mergers and acquisitions in the life insurance industry have had a beneficial effect on efficiency.

Contingencies of value : alternative perspectives for critical theory

Abstract: 1. Fixed Marks and Variable Constancies: A Parable of Value Evaluating Shakespeare's Sonnets Critical Problematics 2. The Exile of Evaluation Fact and Value in the Literary Academy The Politics of Evaluative Criticism An Alternative Project 3. Contingencies of Value Contingency and Interdependence Matters of Taste Processes of Evaluation The Dynamics of Endurance 4. Axiologic Logic Hume's Natural Standard Kant's Pure Judgments Logical Tastes and The Other's Poison Three Postaxiological Postscripts 5. Truth/Value Judgment Typology and Maclntyre's Fall Value without Truth-Value Changing Places: Truth, Error, and Deconstruction 6. The Critiques of Utility Humanism, Anti-Utilitarianism, and the Double Discourse of Value Bataille's Expenditure Endless (Ex)Change 7. Matters of Consequence Critiques and Charges: The Objectivist Generation of "Relativism" Quietism and the Active Relativist Community, Solidarity, and the Pragmatist's Dilemma Politics and Justification Conceptual Tastes and Practical Consequences Notes Index

Global gene expression profiling of circulating tumor cells

Abstract: The present invention provides methods for the generation of global gene expression profiles in circulating tumor cells and the generation of a set of genes used for the diagnosis of cancer. The present invention further provides methods and means for diagnosing cancer by assessubg AGR2 or TFF3 expression in CTC's exposed to physiological stress.

Corporate social performance, analyst stock recommendations, and firm future returns

Abstract: This study posits that security analysts heed corporate social performance information and factor it into their recommendations to general investors. In particular, as corporate social performance is often uncertain and ambiguous to general investors, analysts may serve as the informational pathway connecting corporate social performance to firm stock returns. Thus, we argue that analyst recommendations mediate the relationship between corporate social performance and firm stock returns. On the basis of not only a qualitative study with literature searches and interviews of stock analysts but also a quantitative study with two longitudinal samples of large firms, we find support for these arguments. Our findings uncover an information-based underlying mechanism for the link between corporate social performance and financial performance.