Institution
University of East Anglia
Education•Norwich, Norfolk, United Kingdom•
About: University of East Anglia is a education organization based out in Norwich, Norfolk, United Kingdom. It is known for research contribution in the topics: Population & Climate change. The organization has 13250 authors who have published 37504 publications receiving 1669060 citations. The organization is also known as: UEA.
Papers published on a yearly basis
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Kunming Institute of Zoology1, Griffith University2, University of East Anglia3, Princeton University4, James Cook University5, Xishuangbanna Tropical Botanical Garden6, Queensland Museum7, University of Leeds8, Conservation International9, Columbia University10, Universiti Malaysia Sabah11, Institute of Ecosystem Studies12, University of Florida13, Spanish National Research Council14
TL;DR: Compared with standard biodiversity data sets, metabarcoded samples are taxonomically more comprehensive, many times quicker to produce, less reliant on taxonomic expertise and auditable by third parties, which is essential for dispute resolution.
Abstract: To manage and conserve biodiversity, one must know what is being lost, where, and why, as well as which remedies are likely to be most effective. Metabarcoding technology can characterise the species compositions of mass samples of eukaryotes or of environmental DNA. Here, we validate metabarcoding by testing it against three high-quality standard data sets that were collected in Malaysia (tropical), China (subtropical) and the United Kingdom (temperate) and that comprised 55,813 arthropod and bird specimens identified to species level with the expenditure of 2,505 person-hours of taxonomic expertise. The metabarcode and standard data sets exhibit statistically correlated alpha- and beta-diversities, and the two data sets produce similar policy conclusions for two conservation applications: restoration ecology and systematic conservation planning. Compared with standard biodiversity data sets, metabarcoded samples are taxonomically more comprehensive, many times quicker to produce, less reliant on taxonomic expertise and auditable by third parties, which is essential for dispute resolution.
510 citations
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TL;DR: The evidence for an association between frailty and cognitive impairment is reviewed and some of the mechanisms that potentially underpin this relationship from brain neuropathology and hormonal dysregulation to cardiovascular risk and psychological factors are outlined.
508 citations
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TL;DR: The authors used homogenized near-surface temperature data over the land and oceans of both hemispheres during the past 130 years to produce the first comprehensive estimates of global mean temperature, showing little trend in the nineteenth century, marked warming to 1940, relatively steady conditions to the mid-1970s and subsequent rapid warming.
Abstract: Recent homogenized near-surface temperature data over the land and oceans of both hemispheres during the past 130 years are combined to produce the first comprehensive estimates of global mean temperature. The results show little trend in the nineteenth century, marked warming to 1940, relatively steady conditions to the mid-1970s and a subsequent rapid warming. The warmest 3 years have all occurred in the 1980s.
508 citations
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TL;DR: In this paper, the authors identify entry points and knowledge gaps in relation to mainstreaming climate risks in Ethiopia using the Government's plan for poverty reduction, and end with a case study incorporating climate risks through drought insurance within the current social protection program in Ethiopia, which provides support to 8.3 million people.
Abstract: Africa is widely held to be highly vulnerable to future climate change and Ethiopia is often cited as one of the most extreme examples. With this in mind we seek to identify entry points to integrate short- to medium-term climate risk reduction within development activities in Africa, drawing from experiences in Ethiopia. To achieve this we employ a range of data and methods. We examine the changing nature of climate risks using analysis of recent climate variability, future climate scenarios and their secondary impacts. We assess the effects of climate variability on agricultural production and national GDP. Entry points and knowledge gaps in relation to mainstreaming climate risks in Ethiopia are identified using the Government's plan for poverty reduction. We end with a case study incorporating climate risks through drought insurance within the current social protection programme in Ethiopia, which provides support to 8.3 million people. Rainfall behaviour in Ethiopia shows no marked emergent changes and future climate projections show continued warming but very mixed patterns of rainfall change. Economic analysis highlights sensitivities within the economy to large-scale drought, however, while the effects are clear in major drought years in other years the relationship is weak. For social protection fairly small positive and negative effects on the number of recipients and frequency of cash payments during drought occur under the extreme range of climate model rainfall projections (2020s). Our analysis highlights several important challenges and opportunities for addressing climate risks. Challenges primarily relate to the large uncertainties in climate projections for parts of Africa, a weak evidence base of complex, often non-deterministic, climate–society interactions and institutional issues. Opportunities relate to the potential for low-regrets measures to reduce vulnerability to current climate variability which can be integrated with relatively modest effort within a shift in Africa from a disaster-focused view of climate to a long-term perspective that emphasises livelihood security and vulnerability reduction.
508 citations
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TL;DR: The unicellular alga Chlamydomonas reinhardtii is shown to contain miRNAs, putative evolutionary precursors of mi RNAs and species of siRNAs resembling those in higher plants, indicating that complex RNA-silencing systems evolved before multicellularity and were a feature of primitive eukaryotic cells.
Abstract: MicroRNAs (miRNAs) in eukaryotes guide post-transcriptional regulation by means of targeted RNA degradation and translational arrest. They are released by a Dicer nuclease as a 21-24-nucleotide RNA duplex from a precursor in which an imperfectly matched inverted repeat forms a partly double-stranded region. One of the two strands is then recruited by an Argonaute nuclease that is the effector protein of the silencing mechanism. Short interfering RNAs (siRNAs), which are similar to miRNAs, are also produced by Dicer but the precursors are perfectly double-stranded RNA. These siRNAs guide post-transcriptional regulation, as with miRNAs, and epigenetic genome modification. Diverse eukaryotes including fungi, plants, protozoans and metazoans produce siRNAs but, until now, miRNAs have not been described in unicellular organisms and it has been suggested that they evolved together with multicellularity in separate plant and animal lineages. Here we show that the unicellular alga Chlamydomonas reinhardtii contains miRNAs, putative evolutionary precursors of miRNAs and species of siRNAs resembling those in higher plants. The common features of miRNAs and siRNAs in an alga and in higher plants indicate that complex RNA-silencing systems evolved before multicellularity and were a feature of primitive eukaryotic cells.
507 citations
Authors
Showing all 13512 results
Name | H-index | Papers | Citations |
---|---|---|---|
George Davey Smith | 224 | 2540 | 248373 |
Nicholas J. Wareham | 212 | 1657 | 204896 |
Cyrus Cooper | 204 | 1869 | 206782 |
Kay-Tee Khaw | 174 | 1389 | 138782 |
Phillip A. Sharp | 172 | 614 | 117126 |
Rory Collins | 162 | 489 | 193407 |
William J. Sutherland | 148 | 966 | 94423 |
Shah Ebrahim | 146 | 733 | 96807 |
Kenneth M. Yamada | 139 | 446 | 72136 |
Martin McKee | 138 | 1732 | 125972 |
David Price | 138 | 1687 | 93535 |
Sheila Bingham | 136 | 519 | 67332 |
Philip Jones | 135 | 644 | 90838 |
Peter M. Rothwell | 134 | 779 | 67382 |
Ivan Reid | 131 | 1318 | 85123 |