Institution
Washington State University
Education•Pullman, Washington, United States•
About: Washington State University is a education organization based out in Pullman, Washington, United States. It is known for research contribution in the topics: Population & Gene. The organization has 26947 authors who have published 57736 publications receiving 2341509 citations. The organization is also known as: WSU & Wazzu.
Topics: Population, Gene, Catalysis, Context (language use), Poison control
Papers published on a yearly basis
Papers
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TL;DR: These experiments demonstrate that essential oil quantity and quality can be regulated by metabolic engineering and alteration of the committed step of the mevalonate-independent pathway for supply of terpenoid precursors improves flux through the pathway that leads to increased monoterpene production, and antisense manipulation of a selected downstream monoter pene biosynthetic step leads to improved oil composition.
Abstract: Peppermint (Mentha × piperita L.) was independently transformed with a homologous sense version of the 1-deoxy-d-xylulose-5-phosphate reductoisomerase cDNA and with a homologous antisense version of the menthofuran synthase cDNA, both driven by the CaMV 35S promoter. Two groups of transgenic plants were regenerated in the reductoisomerase experiments, one of which remained normal in appearance and development; another was deficient in chlorophyll production and grew slowly. Transgenic plants of normal appearance and growth habit expressed the reductoisomerase transgene strongly and constitutively, as determined by RNA blot analysis and direct enzyme assay, and these plants accumulated substantially more essential oil (about 50% yield increase) without change in monoterpene composition compared with wild-type. Chlorophyll-deficient plants did not afford detectable reductoisomerase mRNA or enzyme activity and yielded less essential oil than did wild-type plants, indicating cosuppression of the reductoisomerase gene. Plants transformed with the antisense version of the menthofuran synthase cDNA were normal in appearance but produced less than half of this undesirable monoterpene oil component than did wild-type mint grown under unstressed or stressed conditions. These experiments demonstrate that essential oil quantity and quality can be regulated by metabolic engineering. Thus, alteration of the committed step of the mevalonate-independent pathway for supply of terpenoid precursors improves flux through the pathway that leads to increased monoterpene production, and antisense manipulation of a selected downstream monoterpene biosynthetic step leads to improved oil composition.
434 citations
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TL;DR: Based on reports that BPA impacts female reproduction and has the potential to affect male reproductive systems in humans and animals, BPA is a reproductive toxicant, which is considered an ovarian toxicant.
Abstract: Background: In 2007, an expert panel reviewed associations between bisphenol A (BPA) exposure and reproductive health outcomes. Since then, new studies have been conducted on the impact of BPA on r...
433 citations
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TL;DR: In this paper, the Covid-19 pandemic has confronted the hospitality industry with an unprecedented challenge, and strategies to deal with it are discussed, including strategies to mitigate the effects of the pandemic.
Abstract: Due to the Covid-19 pandemic, the world’s economy was shut down almost overnight (UNWTO, 2020). The pandemic has confronted the hospitality industry with an unprecedented challenge. Strategies to f...
433 citations
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TL;DR: In this article, the authors summarize the development of polymer/graphite nanoplatelets (GNP) nanocomposites in recent years, including the fabrication of GNPs and its nan composites, processing issues, viscoelastic properties, mechanical properties, electrical and dielectric properties, thermal conductivity and thermal stability.
Abstract: Graphite nanoplatelets (GNPs) are a type of graphitic nanofillers composed of stacked 2D graphene sheets, having outstanding electrical, thermal, and mechanical properties. Furthermore, owing to the abundance of naturally existing graphite as the source material for GNPs, it is considered an ideal reinforcing component to modify the properties of polymers. The 2D confinement of GNPs to the polymer matrix and the high surface area make the GNP a distinctive nanofiller, showing superiorities in modification of most properties, compared with other carbon nanofillers. This review will summarize the development of polymer/GNP nanocomposites in recent years, including the fabrication of GNPs and its nanocomposites, processing issues, viscoelastic properties, mechanical properties, electrical and dielectric properties, thermal conductivity and thermal stability. The discussion of reinforcing effect will be based on dispersion, particle geometry, concentrations, as well as the 2D structures and exfoliation of GNPs. The synergy of GNPs with other types of carbon nanofillers used as hybrid reinforcing systems shows great potential and could significantly broaden the application of GNPs. The relevant research will also be included in this review.
432 citations
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TL;DR: Dietary astaxanthin decreases a DNA damage biomarker and acute phase protein, and enhances immune response in young healthy females, and is effective in modulating immune response, oxidative status and inflammation in younghealthy adult female human subjects.
Abstract: Astaxanthin modulates immune response, inhibits cancer cell growth, reduces bacterial load and gastric inflammation, and protects against UVA-induced oxidative stress in in vitro and rodent models. Similar clinical studies in humans are unavailable. Our objective is to study the action of dietary astaxanthin in modulating immune response, oxidative status and inflammation in young healthy adult female human subjects. Participants (averaged 21.5 yr) received 0, 2, or 8 mg astaxanthin (n = 14/diet) daily for 8 wk in a randomized double-blind, placebo-controlled study. Immune response was assessed on wk 0, 4 and 8, and tuberculin test performed on wk 8. Plasma astaxanthin increased (P < 0.01) dose-dependently after 4 or 8 wk of supplementation. Astaxanthin decreased a DNA damage biomarker after 4 wk but did not affect lipid peroxidation. Plasma C-reactive protein concentration was lower (P < 0.05) on wk 8 in subjects given 2 mg astaxanthin. Dietary astaxanthin stimulated mitogen-induced lymphoproliferation, increased natural killer cell cytotoxic activity, and increased total T and B cell subpopulations, but did not influence populations of Thelper, Tcytotoxic or natural killer cells. A higher percentage of leukocytes expressed the LFA-1 marker in subjects given 2 mg astaxanthin on wk 8. Subjects fed 2 mg astaxanthin had a higher tuberculin response than unsupplemented subjects. There was no difference in TNF and IL-2 concentrations, but plasma IFN-γ and IL-6 increased on wk 8 in subjects given 8 mg astaxanthin. Therefore, dietary astaxanthin decreases a DNA damage biomarker and acute phase protein, and enhances immune response in young healthy females.
432 citations
Authors
Showing all 27183 results
Name | H-index | Papers | Citations |
---|---|---|---|
Anil K. Jain | 183 | 1016 | 192151 |
Martin Karplus | 163 | 831 | 138492 |
Herbert A. Simon | 157 | 745 | 194597 |
Suvadeep Bose | 154 | 960 | 129071 |
Rajesh Kumar | 149 | 4439 | 140830 |
Kevin Murphy | 146 | 728 | 120475 |
Jonathan D. G. Jones | 129 | 417 | 80908 |
Douglas E. Soltis | 127 | 612 | 67161 |
Peter W. Kalivas | 123 | 428 | 52445 |
Chris Somerville | 122 | 284 | 45742 |
Pamela S. Soltis | 120 | 543 | 61080 |
Yuehe Lin | 118 | 641 | 55399 |
Howard I. Maibach | 116 | 1821 | 60765 |
Jizhong Zhou | 115 | 766 | 48708 |
Farshid Guilak | 110 | 480 | 41327 |