Journal ArticleDOI
AMP-activated protein kinase sparks the fire of cardioprotection against myocardial ischemia and cardiac ageing
TLDR
The structure and role of AMPK in the heart is introduced; followed by the energy regulation of AM PK in MI; and the attention will be expanded to some potential directions and further perspectives.About:
This article is published in Ageing Research Reviews.The article was published on 2018-08-12. It has received 48 citations till now. The article focuses on the topics: AMPK & Cardioprotection.read more
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Targeting AMPK signaling pathway by natural products for treatment of diabetes mellitus and its complications.
Tanuj Joshi,Amit Kumar Singh,Pouya Haratipour,Pouya Haratipour,Archana N. Sah,Abhay K. Pandey,Rozita Naseri,Vijay Juyal,Mohammad Hosein Farzaei +8 more
TL;DR: Natural products like berberine, quercetin, resveratrol, and so forth have shown significant potential in regulating and activating the AMPK pathway which can lead to manage diabetes mellitus and its complications.
Journal ArticleDOI
LncRNA: Shedding light on mechanisms and opportunities in fibrosis and aging
Zhi Yang,Shuai Jiang,Jiajia Shang,Yuting Jiang,Yu Dai,Baoping Xu,Yuan Yu,Zhenxing Liang,Yang Yang +8 more
TL;DR: This review systematically highlights the recent advances regarding the roles of lNCRNAs in fibrosis and sheds light on the use of lncRNAs as a potential treatment for fibrosis.
Journal ArticleDOI
Wnt signaling pathway in aging-related tissue fibrosis and therapies.
TL;DR: The dysregulation of Wnt signaling in aging-related fibrotic tissues such as kidney, liver, lung and cardiac fibrosis is summarized, followed by a detailed discussion of its involvement in organ fibrosis.
Journal ArticleDOI
An Update on the Multifaceted Roles of STAT3 in the Heart.
TL;DR: Through these varied roles, STAT3 participates in various mechanisms that contribute to cardioprotection against different heart pathologies, including myocardial infarction, hypertrophy, diabetic cardiomyopathy, and peripartum cardiopathy, which could lead to novel therapeutic strategies to treat them.
Journal ArticleDOI
Melatonin: Another avenue for treating osteoporosis?
TL;DR: It is hypothesized that melatonin may be a novel remedy for the prevention and clinical treatment of osteoporosis because of its distinct actions on bone metabolism.
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Piel,Dan Poenaru,Suzanne Polinder,Svetlana Popova,Richie Poulton,Farshad Pourmalek,Dorairaj Prabhakaran,Dima M. Qato,Amado D Quezada,D. Alex Quistberg,Felicia A. Rabito,Anwar Rafay,Kazem Rahimi,Vafa Rahimi-Movaghar,Sajjad Ur Rahman,Murugesan Raju,Ivo Rakovac,Saleem M Rana,Saleem M Rana,Amany H Refaat,Giuseppe Remuzzi,Antonio Luiz Pinho Ribeiro,Stefano Ricci,Patricia M. Riccio,Lee Richardson,Jan Hendrik Richardus,Bayard Roberts,D. Allen Roberts,Margaret Robinson,Anna Roca,Alina Rodriguez,David Rojas-Rueda,Luca Ronfani,Robin Room,Gregory A. Roth,Dietrich Rothenbacher,David H. Rothstein,Jane Rowley,Nobhojit Roy,George Mugambage Ruhago,Lesley Rushton,Sankar Sambandam,Kjetil Søreide,Mohammad Yahya Saeedi,Sukanta Saha,Ramesh Sahathevan,Mohammad Ali Sahraian,Berhe W. Sahle,Joshua A. Salomon,Deborah Salvo,Genesis May J. Samonte,Uchechukwu K.A. Sampson,Juan Sanabria,Logan Sandar,Itamar S. 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Tabb,Ken Takahashi,Roberto Tchio Talongwa,Feng Tan,David Tanne,Marcel Tanner,Marcel Tanner,Mohammad Tavakkoli,Braden Te Ao,Carolina Maria Teixeira,Tara Templin,Eric Y. Tenkorang,Abdullah Sulieman Terkawi,Bernadette Thomas,Andrew L. Thorne-Lyman,Amanda G. Thrift,George D. Thurston,Taavi Tillmann,David L. Tirschwell,Imad M. Tleyjeh,Imad M. Tleyjeh,Marcello Tonelli,Fotis Topouzis,Jeffrey A. Towbin,Hideaki Toyoshima,Jefferson Traebert,Bach Xuan Tran,Thomas Truelsen,Ulises Trujillo,Matias Trillini,Zacharie Tsala Dimbuene,Miltiadis K. Tsilimbaris,E. Murat Tuzcu,Clotilde Ubeda,Uche S. Uchendu,Kingsley N. Ukwaja,Eduardo A. Undurraga,Andrew Vallely,Steven van de Vijver,Coen H. Van Gool,Yuri Y Varakin,Tommi Vasankari,Ana Maria Nogales Vasconcelos,Monica S. Vavilala,Narayanaswamy Venketasubramanian,Lakshmi Vijayakumar,Salvador Villalpando,Francesco Saverio Violante,Vasiliy Victorovich Vlassov,Gregory R. Wagner,Stephen G. Waller,JianLi Wang,Linhong Wang,Xiao Rong Wang,Yanping Wang,Tati S. Warouw,Scott Weichenthal,Elisabete Weiderpass,Robert G. Weintraub,Robert G. Weintraub,Wang Wenzhi,Andrea Werdecker,K. Ryan Wessells,Ronny Westerman,Harvey Whiteford,James D. Wilkinson,Thomas N. Williams,Solomon Meseret Woldeyohannes,Charles D.A. Wolfe,Timothy M. Wolock,Anthony D. Woolf,John Q. Wong,Jonathan L. Wright,Sarah Wulf,Brittany Wurtz,Gelin Xu,Yang Yang,Yuichiro Yano,Hiroshi Yatsuya,Paul S. F. Yip,Naohiro Yonemoto,Seok Jun Yoon,Mustafa Z. Younis,Chuanhua Yu,Kim Yun Jin,Maysaa El Sayed Zaki,Mohammed Fouad Zamakhshary,Hajo Zeeb,Yong Zhang,Yong Zhao,Yingfeng Zheng,Jun Zhu,Shankuan Zhu,David Zonies,Xiao Nong Zou,Joseph R. Zunt,Theo Vos,Alan D. Lopez,Alan D. Lopez,Christopher J L Murray,Gabriel Alcalá-Cerra,Howard Hu,Nadim E. Karam,Nsanzimana Sabin,A. M. Temesgen +731 more
TL;DR: In the Global Burden of Disease Study 2013 (GBD 2013) as discussed by the authors, the authors used the GBD 2010 methods with some refinements to improve accuracy applied to an updated database of vital registration, survey, and census data.
Journal ArticleDOI
Heart Disease and Stroke Statistics-2018 Update: A Report From the American Heart Association.
Emelia J. Benjamin,Salim S. Virani,Clifton W. Callaway,Alanna M. Chamberlain,Alex R. Chang,Susan Cheng,Stephanie E. Chiuve,Mary Cushman,Francesca N. Delling,Rajat Deo,Sarah D. de Ferranti,Jane F. Ferguson,Myriam Fornage,Cathleen Gillespie,Carmen R. Isasi,Monik C. Jiménez,Lori C. Jordan,Suzanne E. Judd,Daniel T. Lackland,Judith H. Lichtman,Lynda D. Lisabeth,Simin Liu,Chris T. Longenecker,Pamela L. Lutsey,Jason Mackey,David B. Matchar,Kunihiro Matsushita,Michael E. Mussolino,Khurram Nasir,Martin O'Flaherty,Latha Palaniappan,Ambarish Pandey,Dilip K. Pandey,Mathew J. Reeves,Matthew D. Ritchey,Carlos J. Rodriguez,Gregory A. Roth,Wayne D. Rosamond,Uchechukwu K.A. Sampson,Gary Satou,Svati H. Shah,Nicole L. Spartano,David L. Tirschwell,Connie W. Tsao,Jenifer H. Voeks,Joshua Z. Willey,John T. Wilkins,Jason H Y Wu,Heather M. Alger,Sally S. Wong,Paul Muntner +50 more
TL;DR: The Statistical Update represents the most up-to-date statistics related to heart disease, stroke, and the cardiovascular risk factors listed in the AHA's My Life Check - Life’s Simple 7, which include core health behaviors and health factors that contribute to cardiovascular health.
Journal ArticleDOI
Metabolism of inflammation limited by AMPK and pseudo-starvation
TL;DR: Metabolic changes in cells that participate in inflammation, such as activated macrophages and T-helper 17 cells, include a shift towards enhanced glucose uptake, glycolysis and increased activity of the pentose phosphate pathway.
Journal ArticleDOI
Neurodevelopmental outcome at 2 years of age after general anaesthesia and awake-regional anaesthesia in infancy (GAS): an international multicentre, randomised controlled trial
Andrew Davidson,Nicola Disma,Jurgen C. de Graaff,Davinia E. Withington,Liam Dorris,Graham Bell,Robyn Stargatt,Robyn Stargatt,David C. Bellinger,David C. Bellinger,Tibor Schuster,Sarah J Arnup,Pollyanna Hardy,Rodney W. Hunt,Rodney W. Hunt,Michael Takagi,Gaia Giribaldi,Penelope L Hartmann,Ida Salvo,Neil S. Morton,Britta S von Ungern Sternberg,Britta S von Ungern Sternberg,Bruno Guido Locatelli,Niall C. T. Wilton,Anne M. Lynn,Joss J. Thomas,David M. Polaner,Oliver Bagshaw,Peter Szmuk,Anthony Absalom,Geoff Frawley,Charles B. Berde,Gillian D Ormond,Jacki Marmor,Mary Ellen McCann +34 more
TL;DR: This trial found no evidence that just under an hour of sevoflurane anaesthesia in infancy increases the risk of adverse neurodevelopmental outcome at two years of age compared to RA.
Journal ArticleDOI
Structure of mammalian AMPK and its regulation by ADP
Bing Xiao,Matthew J. Sanders,Matthew J. Sanders,Elizabeth Underwood,Richard Heath,Faith V. Mayer,David Carmena,Chun-Xia Jing,Philip A. Walker,John F. Eccleston,Lesley F. Haire,Peter Saiu,Steven Howell,Rein Aasland,Stephen R. Martin,David Carling,Steven J. Gamblin +16 more
TL;DR: It is shown that ADP binding to just one of the two exchangeable AXP (AMP/ADP/ATP) binding sites on the regulatory domain protects the enzyme from dephosphorylation, although it does not lead to allosteric activation.