Biomimetic mineralization of metal-organic frameworks as protective coatings for biomacromolecules.
Kang Liang,Raffaele Ricco,Cara M. Doherty,Mark J. Styles,Stephen Bell,Nigel Kirby,Stephen T. Mudie,David N. Haylock,Anita J. Hill,Christian J. Doonan,Paolo Falcaro +10 more
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TLDR
It is shown that proteins, enzymes and DNA rapidly induce the formation of protective metal-organic framework coatings under physiological conditions by concentrating the framework building blocks and facilitating crystallization around the biomacromolecules.Abstract:
Robust biomacromolecules could be used for a wide range of biotechnological applications. Here the authors report a biomimetic mineralization process, in which biomolecules are encapsulated within metal-organic frameworks, and their stability is subsequently increased without significant bioactivity loss.read more
Citations
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Bioactive MIL-88A Framework Hollow Spheres via Interfacial Reaction In-Droplet Microfluidics for Enzyme and Nanoparticle Encapsulation
Guan-Young Jeong,Raffaele Ricco,Kang Liang,Johanna Ludwig,Jin-Oh Kim,Paolo Falcaro,Dong-Pyo Kim +6 more
TL;DR: In this article, the authors synthesize functional bio-MOF hollow spheres with controlled size in the 35-2000 μm range using a continuous-flow droplet microfluidic system in a single step and one-flow strategy.
Journal ArticleDOI
Template‐Directed Synthesis of Porous and Protective Core–Shell Bionanoparticles
Shaobo Li,Madushani Dharmarwardana,Raymond P. Welch,Yixin Ren,Christina M. Thompson,Ronald A. Smaldone,Jeremiah J. Gassensmith +6 more
TL;DR: It is shown how a robust protein template, tobacco mosaic virus (TMV), can be used to regulate the size and shape of as-fabricated MOF materials, and discrete rod-shaped TMV@MOF core-shell hybrids with good uniformity are obtained.
Journal ArticleDOI
Encapsulation of Plasmid DNA by Nanoscale Metal–Organic Frameworks for Efficient Gene Transportation and Expression
Yantao Li,Kai Zhang,Porun Liu,Mo Chen,Yu Lin Zhong,Qingsong Ye,Ming Q. Wei,Huijun Zhao,Zhiyong Tang +8 more
TL;DR: From in vitro experiments, the cellular uptake and endosomal escape of the protected pDNA are greatly improved with the superior ZIF‐8‐PEI 25 kD vector, leading to successful gene expression with high transfection efficacy, comparable to expensive commercial agents.
Journal ArticleDOI
Biomineralization-mimetic preparation of hybrid membranes with ultra-high loading of pristine metal–organic frameworks grown on silk nanofibers for hazard collection in water
Zhishang Li,Guanshan Zhou,Huang Dai,Mingying Yang,Yingchun Fu,Yibin Ying,Yanbin Li,Yanbin Li +7 more
TL;DR: In this article, the authors proposed the preparation of electrospun-silk-nanofiber (ESF)@MOF (ZIF-8 or ZIF-67) hybrid membranes with pristine MOFs densely loaded to efficiently remove pollutants in water.
Journal ArticleDOI
Enzyme embedded metal organic framework (enzyme-MOF): De novo approaches for immobilization.
TL;DR: This review presents a holistic insight of two different de novo strategies i.e. co-precipitation and biomineralization with state-of-art examples of enzyme-MOF biocomposites in terms of catalytic activity, thermal/chemical stability, Michaelis-Menten kinetics, recyclability and storage stability.
References
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Omar M. Yaghi,Michael O'Keeffe,Nathan W. Ockwig,Hee K. Chae,Hee K. Chae,Mohamed Eddaoudi,Jaheon Kim +6 more
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Kyo Sung Park,Zheng Ni,Adrien P. Côté,Jae Yong Choi,Rudan Huang,Fernando J. Uribe-Romo,Hee K. Chae,Michael O'Keeffe,Omar M. Yaghi +8 more
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The assay of catalases and peroxidases.
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TL;DR: Metal Organic Frameworks in Biomedicine Patricia Horcajada, Ruxandra Gref, Tarek Baati, Phoebe K. Allan, Guillaume Maurin, Patrick Couvreur, G erard F erey, Russell E. Morris, and Christian Serre.