Biomimetic mineralization of metal-organic frameworks as protective coatings for biomacromolecules.
Kang Liang,Raffaele Ricco,Cara M. Doherty,Mark J. Styles,Stephen Bell,Nigel Kirby,Stephen T. Mudie,David N. Haylock,Anita J. Hill,Christian J. Doonan,Paolo Falcaro +10 more
Reads0
Chats0
TLDR
It is shown that proteins, enzymes and DNA rapidly induce the formation of protective metal-organic framework coatings under physiological conditions by concentrating the framework building blocks and facilitating crystallization around the biomacromolecules.Abstract:
Robust biomacromolecules could be used for a wide range of biotechnological applications. Here the authors report a biomimetic mineralization process, in which biomolecules are encapsulated within metal-organic frameworks, and their stability is subsequently increased without significant bioactivity loss.read more
Citations
More filters
Journal ArticleDOI
Multifunctional Nanoparticles by Coordinative Self-Assembly of His-Tagged Units with Metal–Organic Frameworks
Ruth Röder,Tobias Preiß,Patrick Hirschle,Benjamin Steinborn,Andreas Zimpel,Miriam Höhn,Joachim O. Rädler,Thomas Bein,Ernst Wagner,Stefan Wuttke,Ulrich Lächelt +10 more
TL;DR: The coordinative interaction of oligohistidine-tags (His-tags) with metal-organic framework nanoparticles (MOF NPs) is presented and the reported functionalization approach opens great flexibility for the targeted synthesis of multifunctional NPs for specific purposes.
Journal ArticleDOI
Modulating the Biofunctionality of Metal-Organic-Framework-Encapsulated Enzymes through Controllable Embedding Patterns.
Guosheng Chen,Xiaoxue Kou,Siming Huang,Linjing Tong,Yujian Shen,Wangshu Zhu,Fang Zhu,Gangfeng Ouyang,Gangfeng Ouyang +8 more
TL;DR: These findings show that the enzymes@MOFs, wherein the encapsulation process is driven by the rapid enzymes-triggered nucleation of ZIF-8, can maintain high enzymatic activity comparable to the free enzymes.
Journal ArticleDOI
Metal-organic frameworks for precise inclusion of single-stranded DNA and transfection in immune cells.
Shuang Peng,Binglin Bie,Yangzesheng Sun,Min Liu,Hengjiang Cong,Wentao Zhou,Yucong Xia,Heng Tang,Hexiang Deng,Xiang Zhou +9 more
TL;DR: The authors report on the design of metal-organic-framework vectors with precisely controlled pore geometry and demonstrate the vector in the transfection of immune cells.
Journal ArticleDOI
Encapsulation of lipase within metal-organic framework (MOF) with enhanced activity intensified under ultrasound.
TL;DR: The enzyme under lower-intensity ultrasonic irradiation leads to favorable conformational changes, thereby enhancing its activity, and this highly activated lipase was encapsulated within zeolite imidazolate framework-8 as a metal-organic framework (MOF) material via facile one-step biomineralization method.
Journal ArticleDOI
Degradation of ZIF-8 in phosphate buffered saline media
Miriam de J. Velásquez-Hernández,Raffaele Ricco,Francesco Carraro,F. Ted Limpoco,Mercedes Linares-Moreau,Erich Leitner,Helmar Wiltsche,Johannes Rattenberger,Hartmuth Schröttner,Philipp Frühwirt,Eduard Stadler,Georg Gescheidt,Heinz Amenitsch,Christian J. Doonan,Paolo Falcaro,Paolo Falcaro +15 more
TL;DR: The stability of zeolitic imidazolate framework-8 (ZIF-8) under physiological conditions is critical in biotechnology and biomedicine for biosensing, biocatalysis, and drug delivery.
References
More filters
Journal ArticleDOI
The Chemistry and Applications of Metal-Organic Frameworks
Hiroyasu Furukawa,Hiroyasu Furukawa,Kyle E. Cordova,Kyle E. Cordova,Michael O'Keeffe,Michael O'Keeffe,Omar M. Yaghi,Omar M. Yaghi,Omar M. Yaghi +8 more
TL;DR: Metal-organic frameworks are porous materials that have potential for applications such as gas storage and separation, as well as catalysis, and methods are being developed for making nanocrystals and supercrystals of MOFs for their incorporation into devices.
Journal ArticleDOI
Reticular synthesis and the design of new materials
Omar M. Yaghi,Michael O'Keeffe,Nathan W. Ockwig,Hee K. Chae,Hee K. Chae,Mohamed Eddaoudi,Jaheon Kim +6 more
TL;DR: This work has shown that highly porous frameworks held together by strong metal–oxygen–carbon bonds and with exceptionally large surface area and capacity for gas storage have been prepared and their pore metrics systematically varied and functionalized.
Journal ArticleDOI
Exceptional chemical and thermal stability of zeolitic imidazolate frameworks
Kyo Sung Park,Zheng Ni,Adrien P. Côté,Jae Yong Choi,Rudan Huang,Fernando J. Uribe-Romo,Hee K. Chae,Michael O'Keeffe,Omar M. Yaghi +8 more
TL;DR: Study of the gas adsorption and thermal and chemical stability of two prototypical members, ZIF-8 and -11, demonstrated their permanent porosity, high thermal stability, and remarkable chemical resistance to boiling alkaline water and organic solvents.
Book ChapterDOI
The assay of catalases and peroxidases.
Britton Chance,A.C. Maehly +1 more
TL;DR: Two methods are described for the catalase assay by disappearance of peroxide are: ultraviolet spectrophotometry and permanganate titration and indirect measurements of the decrease of light absorption caused by the decomposition of hydrogen peroxide byCatalase.
Journal ArticleDOI
Metal-organic frameworks in biomedicine.
Patricia Horcajada,Ruxandra Gref,Tarek Baati,Phoebe K. Allan,Guillaume Maurin,Patrick Couvreur,Gérard Férey,Russell E. Morris,Christian Serre +8 more
TL;DR: Metal Organic Frameworks in Biomedicine Patricia Horcajada, Ruxandra Gref, Tarek Baati, Phoebe K. Allan, Guillaume Maurin, Patrick Couvreur, G erard F erey, Russell E. Morris, and Christian Serre.