Biomimetic mineralization of metal-organic frameworks as protective coatings for biomacromolecules.
Kang Liang,Raffaele Ricco,Cara M. Doherty,Mark J. Styles,Stephen Bell,Nigel Kirby,Stephen T. Mudie,David N. Haylock,Anita J. Hill,Christian J. Doonan,Paolo Falcaro +10 more
TLDR
It is shown that proteins, enzymes and DNA rapidly induce the formation of protective metal-organic framework coatings under physiological conditions by concentrating the framework building blocks and facilitating crystallization around the biomacromolecules.Abstract:
Robust biomacromolecules could be used for a wide range of biotechnological applications. Here the authors report a biomimetic mineralization process, in which biomolecules are encapsulated within metal-organic frameworks, and their stability is subsequently increased without significant bioactivity loss.read more
Citations
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Covalent immobilization of glucose oxidase on amino MOFs via post-synthetic modification
Cristina Tudisco,Cristina Tudisco,Giedrius Zolubas,Beatriz Seoane,Hamid Reza Zafarani,Mahmood Kazemzad,Jorge Gascon,Peter-Leon Hagedoorn,Liza Rassaei +8 more
TL;DR: The post-synthetic modification of two amino-MOFs with glucose oxidase with multi-step approach preserved the MOFs' structure and allowed the production of enzyme-functionalized MOFs (MOFs@GOx), which retained the enzymatic activity and showed selective properties for glucose.
Journal ArticleDOI
Metal-Organic Framework-Plant Nanobiohybrids as Living Sensors for On-Site Environmental Pollutant Detection.
Jieying Liang,Muhammad Yazid Zulkifli,Samantha Choy,Yong Li,Meng Gao,Biao Kong,Jimmy Yun,Jimmy Yun,Kang Liang +8 more
TL;DR: The results suggest that interfacing synthetic and living materials may contribute to the development of smart sensors for on-site environmental pollutants sensing with high accuracy.
Journal ArticleDOI
Enzyme Shielding in an Enzyme‐thin and Soft Organosilica Layer
M. Rita Correro,Negar Moridi,Hansjörg Schützinger,Sabine Sykora,Erik M. Ammann,E. Henrik Peters,Yves Dudal,Philippe F.-X. Corvini,Philippe F.-X. Corvini,Patrick Shahgaldian +9 more
TL;DR: A synthetic chemical strategy is described to produce hybrid organic/inorganic nanobiocatalysts by exploiting the self-assembly of silane building blocks at the surface of enzymes to grow an organosilica layer, of controlled thickness, that fully shields the enzyme.
Journal ArticleDOI
BMP-6 carrying metal organic framework-embedded in bioresorbable electrospun fibers for enhanced bone regeneration.
TL;DR: The results proved that; MOF-carriers embedded in electrospun scaffolds can be used as an effective platform for bone regeneration in bone tissue engineering applications.
Journal ArticleDOI
Long‐Persistent Enzyme‐MOF Nanoreactor Activates Non‐toxic Paracetamol for Cancer Therapy
Xizhen Lian,Yanyan Huang,Yuanyuan Zhu,Yu Fang,Rui Zhao,Elizabeth A. Joseph,Jialuo Li,Jean-Phillipe Pellois,Hong-Cai Zhou +8 more
TL;DR: It is demonstrated that enzymatic nanoreactors based on metal-organic frameworks (MOFs) can be potent prodrug activators and envision enzyme-MOF nanocomposites to be novel long-persistent platforms for various biomedical applications.
References
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Journal ArticleDOI
The Chemistry and Applications of Metal-Organic Frameworks
Hiroyasu Furukawa,Hiroyasu Furukawa,Kyle E. Cordova,Kyle E. Cordova,Michael O'Keeffe,Michael O'Keeffe,Omar M. Yaghi,Omar M. Yaghi,Omar M. Yaghi +8 more
TL;DR: Metal-organic frameworks are porous materials that have potential for applications such as gas storage and separation, as well as catalysis, and methods are being developed for making nanocrystals and supercrystals of MOFs for their incorporation into devices.
Journal ArticleDOI
Reticular synthesis and the design of new materials
Omar M. Yaghi,Michael O'Keeffe,Nathan W. Ockwig,Hee K. Chae,Hee K. Chae,Mohamed Eddaoudi,Jaheon Kim +6 more
TL;DR: This work has shown that highly porous frameworks held together by strong metal–oxygen–carbon bonds and with exceptionally large surface area and capacity for gas storage have been prepared and their pore metrics systematically varied and functionalized.
Journal ArticleDOI
Exceptional chemical and thermal stability of zeolitic imidazolate frameworks
Kyo Sung Park,Zheng Ni,Adrien P. Côté,Jae Yong Choi,Rudan Huang,Fernando J. Uribe-Romo,Hee K. Chae,Michael O'Keeffe,Omar M. Yaghi +8 more
TL;DR: Study of the gas adsorption and thermal and chemical stability of two prototypical members, ZIF-8 and -11, demonstrated their permanent porosity, high thermal stability, and remarkable chemical resistance to boiling alkaline water and organic solvents.
Book ChapterDOI
The assay of catalases and peroxidases.
Britton Chance,A.C. Maehly +1 more
TL;DR: Two methods are described for the catalase assay by disappearance of peroxide are: ultraviolet spectrophotometry and permanganate titration and indirect measurements of the decrease of light absorption caused by the decomposition of hydrogen peroxide byCatalase.
Journal ArticleDOI
Metal-organic frameworks in biomedicine.
Patricia Horcajada,Ruxandra Gref,Tarek Baati,Phoebe K. Allan,Guillaume Maurin,Patrick Couvreur,Gérard Férey,Russell E. Morris,Christian Serre +8 more
TL;DR: Metal Organic Frameworks in Biomedicine Patricia Horcajada, Ruxandra Gref, Tarek Baati, Phoebe K. Allan, Guillaume Maurin, Patrick Couvreur, G erard F erey, Russell E. Morris, and Christian Serre.