Biomimetic mineralization of metal-organic frameworks as protective coatings for biomacromolecules.
Kang Liang,Raffaele Ricco,Cara M. Doherty,Mark J. Styles,Stephen Bell,Nigel Kirby,Stephen T. Mudie,David N. Haylock,Anita J. Hill,Christian J. Doonan,Paolo Falcaro +10 more
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TLDR
It is shown that proteins, enzymes and DNA rapidly induce the formation of protective metal-organic framework coatings under physiological conditions by concentrating the framework building blocks and facilitating crystallization around the biomacromolecules.Abstract:
Robust biomacromolecules could be used for a wide range of biotechnological applications. Here the authors report a biomimetic mineralization process, in which biomolecules are encapsulated within metal-organic frameworks, and their stability is subsequently increased without significant bioactivity loss.read more
Citations
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Antioxidative Composites Based on Multienzyme Systems Encapsulated in Metal-Organic Frameworks.
TL;DR: In this article, the authors developed enzyme-MOF composites, SC@ZIF-8, which exhibited an excellent antioxidative activity in vitro, which enabled the successful delivery of enzymes into the cytoplasm to scavenge toxic ROS.
Journal ArticleDOI
Peptide-functionalized metal-organic framework nanocomposite for ultrasensitive detection of secreted protein acidic and rich in cysteine with practical application.
TL;DR: In this article, a peptide-functionalized metal-organic frameworks (MOFs) are used as signal-amplifying tags for the detection of secreted protein acidic and rich in cysteine (SPARC).
Journal ArticleDOI
Low doses of zeolitic imidazolate framework-8 nanoparticles alter the actin organization and contractility of vascular smooth muscle cells.
TL;DR: In this paper, the effects of low doses of ZIF-8 nanoparticles on vascular smooth muscle cells (VSMCs) morphology, actin organization, and contractility are investigated.
Journal ArticleDOI
Point‐of‐care detection of cytokines in cytokine storm management and beyond: Significance and challenges
TL;DR: The overview of diseases resulting from imbalanced cytokine levels, such as COVID‐19, sepsis and other cytokine release syndromes are presented, and the clinical cut‐off levels of cytokine as biomarkers for different diseases are summarized.
Journal ArticleDOI
Metal–Organic Framework-Enhanced ELISA Platform for Ultrasensitive Detection of PD-L1
Sareh Zhand,Amir Razmjou,Amir Razmjou,Shohreh Azadi,Sajad Razavi Bazaz,Jesus Shrestha,Mahsa Asadnia Fard Jahromi,Mahsa Asadnia Fard Jahromi,Majid Ebrahimi Warkiani,Majid Ebrahimi Warkiani +9 more
TL;DR: The proposed MOF-based ELISA for the detection of the PD-L1 protein has significant potential for the clinical and diagnostic studies and can provide sensitive detection for target proteins, in addition to being resistant to elevated temperature and pH.
References
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The Chemistry and Applications of Metal-Organic Frameworks
Hiroyasu Furukawa,Hiroyasu Furukawa,Kyle E. Cordova,Kyle E. Cordova,Michael O'Keeffe,Michael O'Keeffe,Omar M. Yaghi,Omar M. Yaghi,Omar M. Yaghi +8 more
TL;DR: Metal-organic frameworks are porous materials that have potential for applications such as gas storage and separation, as well as catalysis, and methods are being developed for making nanocrystals and supercrystals of MOFs for their incorporation into devices.
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Reticular synthesis and the design of new materials
Omar M. Yaghi,Michael O'Keeffe,Nathan W. Ockwig,Hee K. Chae,Hee K. Chae,Mohamed Eddaoudi,Jaheon Kim +6 more
TL;DR: This work has shown that highly porous frameworks held together by strong metal–oxygen–carbon bonds and with exceptionally large surface area and capacity for gas storage have been prepared and their pore metrics systematically varied and functionalized.
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Exceptional chemical and thermal stability of zeolitic imidazolate frameworks
Kyo Sung Park,Zheng Ni,Adrien P. Côté,Jae Yong Choi,Rudan Huang,Fernando J. Uribe-Romo,Hee K. Chae,Michael O'Keeffe,Omar M. Yaghi +8 more
TL;DR: Study of the gas adsorption and thermal and chemical stability of two prototypical members, ZIF-8 and -11, demonstrated their permanent porosity, high thermal stability, and remarkable chemical resistance to boiling alkaline water and organic solvents.
Book ChapterDOI
The assay of catalases and peroxidases.
Britton Chance,A.C. Maehly +1 more
TL;DR: Two methods are described for the catalase assay by disappearance of peroxide are: ultraviolet spectrophotometry and permanganate titration and indirect measurements of the decrease of light absorption caused by the decomposition of hydrogen peroxide byCatalase.
Journal ArticleDOI
Metal-organic frameworks in biomedicine.
Patricia Horcajada,Ruxandra Gref,Tarek Baati,Phoebe K. Allan,Guillaume Maurin,Patrick Couvreur,Gérard Férey,Russell E. Morris,Christian Serre +8 more
TL;DR: Metal Organic Frameworks in Biomedicine Patricia Horcajada, Ruxandra Gref, Tarek Baati, Phoebe K. Allan, Guillaume Maurin, Patrick Couvreur, G erard F erey, Russell E. Morris, and Christian Serre.